{"id":"https://openalex.org/W4413049283","doi":"https://doi.org/10.1016/j.cmpb.2026.109405","title":"High-resolution 3D flow reconstruction of cerebrospinal fluid microcirculation using physics-informed neural network: Conceptualization and application to a large animal model","display_name":"High-resolution 3D flow reconstruction of cerebrospinal fluid microcirculation using physics-informed neural network: Conceptualization and application to a large animal model","publication_year":2026,"publication_date":"2026-04-24","ids":{"openalex":"https://openalex.org/W4413049283","doi":"https://doi.org/10.1016/j.cmpb.2026.109405","pmid":"https://pubmed.ncbi.nlm.nih.gov/42114465"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmpb.2026.109405","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2026.109405","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5381020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068652506","display_name":"Mark Epshtein","orcid":"https://orcid.org/0000-0002-1164-7331"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Epshtein","raw_affiliation_strings":["University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA"],"raw_orcid":"https://orcid.org/0000-0002-1164-7331","affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008261147","display_name":"Tirosh Mekler","orcid":"https://orcid.org/0009-0008-7921-7064"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tirosh Mekler","raw_affiliation_strings":["Technion Israel Institute of Technology, Department of Biomedical Engineering, Haifa 32000, Israel"],"raw_orcid":"https://orcid.org/0009-0008-7921-7064","affiliations":[{"raw_affiliation_string":"Technion Israel Institute of Technology, Department of Biomedical Engineering, Haifa 32000, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017592912","display_name":"Mohammed Salman Shazeeb","orcid":"https://orcid.org/0000-0002-3175-8098"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Salman Shazeeb","raw_affiliation_strings":["University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA"],"raw_orcid":"https://orcid.org/0000-0002-3175-8098","affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054724759","display_name":"Clifford Lindsay","orcid":"https://orcid.org/0000-0003-3249-2807"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Lindsay","raw_affiliation_strings":["University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005530966","display_name":"Matthew J. Gounis","orcid":"https://orcid.org/0000-0002-8034-2785"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew J Gounis","raw_affiliation_strings":["University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA. Electronic address: matthew.gounis@umassmed.edu"],"raw_orcid":"https://orcid.org/0000-0002-8034-2785","affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA. Electronic address: matthew.gounis@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006947163","display_name":"Netanel Korin","orcid":"https://orcid.org/0000-0001-7244-889X"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Netanel Korin","raw_affiliation_strings":["Technion Israel Institute of Technology, Department of Biomedical Engineering, Haifa 32000, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technion Israel Institute of Technology, Department of Biomedical Engineering, Haifa 32000, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"last","author":{"id":null,"display_name":"Vania Anagnostakou","orcid":"https://orcid.org/0000-0001-5101-3192"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vania Anagnostakou","raw_affiliation_strings":["University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA"],"raw_orcid":"https://orcid.org/0000-0001-5101-3192","affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School, Department of Radiology, New England Center for Stroke Research, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005530966"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00626364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"283","issue":null,"first_page":"109405","last_page":"109405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9799000024795532,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9602000117301941,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conceptualization","display_name":"Conceptualization","score":0.8592158555984497},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.529242217540741},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"Cerebrospinal fluid","score":0.5207160115242004},{"id":"https://openalex.org/keywords/fluid-dynamics","display_name":"Fluid dynamics","score":0.4952944815158844},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.4641028642654419},{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.41332173347473145},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3869674801826477},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.33443573117256165},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3318803906440735},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3014291524887085},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.24429044127464294},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23917821049690247},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1891534924507141},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.13489484786987305}],"concepts":[{"id":"https://openalex.org/C90734943","wikidata":"https://www.wikidata.org/wiki/Q17008777","display_name":"Conceptualization","level":2,"score":0.8592158555984497},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.529242217540741},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5207160115242004},{"id":"https://openalex.org/C90278072","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Fluid dynamics","level":2,"score":0.4952944815158844},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4641028642654419},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.41332173347473145},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3869674801826477},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33443573117256165},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3318803906440735},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3014291524887085},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.24429044127464294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23917821049690247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1891534924507141},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13489484786987305}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013346","descriptor_name":"Subarachnoid Space","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cmpb.2026.109405","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2026.109405","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5381020","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5381020","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42114465","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42114465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer methods and programs in biomedicine","raw_type":null}],"best_oa_location":{"id":"doi:10.2139/ssrn.5381020","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5381020","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2028623620","https://openalex.org/W2137273166","https://openalex.org/W2167183660","https://openalex.org/W2315601225","https://openalex.org/W2899283552","https://openalex.org/W2901166225","https://openalex.org/W2979786244","https://openalex.org/W3046564271","https://openalex.org/W3107547143","https://openalex.org/W3139138061","https://openalex.org/W3163993681","https://openalex.org/W3197473870","https://openalex.org/W4210423197","https://openalex.org/W4210733241","https://openalex.org/W4294325216","https://openalex.org/W4307154444","https://openalex.org/W4320497786","https://openalex.org/W4361298605","https://openalex.org/W4382398246","https://openalex.org/W4389681626","https://openalex.org/W4392078868","https://openalex.org/W4396917778","https://openalex.org/W4398202808","https://openalex.org/W4408339746","https://openalex.org/W4413164949"],"related_works":["https://openalex.org/W4362575170","https://openalex.org/W1532772865","https://openalex.org/W2531253623","https://openalex.org/W2984230149","https://openalex.org/W2112095637","https://openalex.org/W2237121679","https://openalex.org/W4390616414","https://openalex.org/W2006867289","https://openalex.org/W3212890177","https://openalex.org/W1188194610"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}
