{"id":"https://openalex.org/W7130566815","doi":"https://doi.org/10.1016/j.cmpb.2026.109290","title":"An automated computational pipeline for generating large-scale cohorts of patient-specific ventricular models in electromechanical in silico trials","display_name":"An automated computational pipeline for generating large-scale cohorts of patient-specific ventricular models in electromechanical in silico trials","publication_year":2026,"publication_date":"2026-02-20","ids":{"openalex":"https://openalex.org/W7130566815","doi":"https://doi.org/10.1016/j.cmpb.2026.109290","pmid":"https://pubmed.ncbi.nlm.nih.gov/41759486"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmpb.2026.109290","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2026.109290","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cmpb.2026.109290","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123396121","display_name":"Rub\u00e9n Doste","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210146410","display_name":"Science Oxford","ror":"https://ror.org/04j8yhy50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210146410"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ruben Doste","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK. Electronic address: ruben.doste@cs.ox.ac.uk"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK. Electronic address: ruben.doste@cs.ox.ac.uk","institution_ids":["https://openalex.org/I4210146410","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126395068","display_name":"Julia Camps","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia Camps","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064912674","display_name":"Zhinuo Jenny Wang","orcid":"https://orcid.org/0000-0001-5325-909X"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhinuo Jenny Wang","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012447652","display_name":"Lucas Arantes Berg","orcid":"https://orcid.org/0000-0002-8777-0125"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucas Arantes Berg","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103889815","display_name":"Maxx Holmes","orcid":"https://orcid.org/0000-0002-2299-9455"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maxx Holmes","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126422937","display_name":"Hannah Smith","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Smith","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084723622","display_name":"Marcel Beetz","orcid":"https://orcid.org/0009-0004-5239-9313"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marcel Beetz","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126392909","display_name":"Lei Li","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126425376","display_name":"Abhirup Banerjee","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abhirup Banerjee","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109829872","display_name":"Vicente Ferrer Grau","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vicente Grau","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5126425847","display_name":"Blanca Rodriguez","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Blanca Rodriguez","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5123396121"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210146410"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":{"value":2880,"currency":"USD","value_usd":2880},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59168902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"279","issue":null,"first_page":"109290","last_page":"109290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6730999946594238,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6730999946594238,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.7472000122070312},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7289000153541565},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4634000062942505},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.46219998598098755},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.3725999891757965},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.3610000014305115},{"id":"https://openalex.org/keywords/automation","display_name":"Automation","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.7472000122070312},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7289000153541565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7077999711036682},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4634000062942505},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.46219998598098755},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4253000020980835},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3725999891757965},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3199000060558319},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C3019813237","wikidata":"https://www.wikidata.org/wiki/Q65089264","display_name":"Model validation","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.2992999851703644},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.2888999879360199},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C2984968299","wikidata":"https://www.wikidata.org/wiki/Q1077784","display_name":"Software tool","level":3,"score":0.25099998712539673}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cmpb.2026.109290","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2026.109290","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},{"id":"pmid:41759486","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41759486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer methods and programs in biomedicine","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.cmpb.2026.109290","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2026.109290","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1951124667","https://openalex.org/W1981301099","https://openalex.org/W2060292275","https://openalex.org/W2070703456","https://openalex.org/W2082704080","https://openalex.org/W2132401137","https://openalex.org/W2132670047","https://openalex.org/W2605370065","https://openalex.org/W2634752056","https://openalex.org/W2754002459","https://openalex.org/W2778287023","https://openalex.org/W2790442105","https://openalex.org/W2806810105","https://openalex.org/W2885942414","https://openalex.org/W2952202508","https://openalex.org/W2996036235","https://openalex.org/W3001465925","https://openalex.org/W3008375286","https://openalex.org/W3010152544","https://openalex.org/W3012286054","https://openalex.org/W3027941160","https://openalex.org/W3092728049","https://openalex.org/W3106801472","https://openalex.org/W3119341024","https://openalex.org/W3131850410","https://openalex.org/W3153574682","https://openalex.org/W3154140051","https://openalex.org/W3156808959","https://openalex.org/W3158586821","https://openalex.org/W3166488131","https://openalex.org/W3177252448","https://openalex.org/W3196127649","https://openalex.org/W3200644657","https://openalex.org/W3211056089","https://openalex.org/W4294167451","https://openalex.org/W4296096676","https://openalex.org/W4320484271","https://openalex.org/W4365145231","https://openalex.org/W4379745270","https://openalex.org/W4385064158","https://openalex.org/W4386986709","https://openalex.org/W4389782985","https://openalex.org/W4391070750","https://openalex.org/W4392093351","https://openalex.org/W4392247018","https://openalex.org/W4395004261","https://openalex.org/W4399676887","https://openalex.org/W4402581776","https://openalex.org/W4403532250","https://openalex.org/W4405359303","https://openalex.org/W4406658042","https://openalex.org/W4413232484"],"related_works":[],"abstract_inverted_index":{"By":[0],"establishing":[1],"an":[2],"automated":[3],"framework":[4],"for":[5,12],"large":[6],"scale":[7],"simulation":[8],"studies":[9],"as":[10],"required":[11],"in":[13,29],"silico":[14],"trials":[15],"and":[16,31],"providing":[17],"open-source":[18],"code,":[19],"our":[20],"work":[21],"aims":[22],"to":[23],"support":[24],"scalable,":[25],"personalised":[26],"cardiac":[27],"simulations":[28],"research":[30],"clinical":[32],"applications.":[33]},"counts_by_year":[],"updated_date":"2026-03-22T08:09:32.410652","created_date":"2026-02-20T00:00:00"}