{"id":"https://openalex.org/W7163184408","doi":"https://doi.org/10.1016/j.bspc.2026.110718","title":"Degeneration of spiral ganglion neuron dendrites is the primary limitation: A computational study of multipolar cochlear implant stimulation","display_name":"Degeneration of spiral ganglion neuron dendrites is the primary limitation: A computational study of multipolar cochlear implant stimulation","publication_year":2026,"publication_date":"2026-06-02","ids":{"openalex":"https://openalex.org/W7163184408","doi":"https://doi.org/10.1016/j.bspc.2026.110718"},"language":"en","primary_location":{"id":"doi:10.1016/j.bspc.2026.110718","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bspc.2026.110718","pdf_url":null,"source":{"id":"https://openalex.org/S8427965","display_name":"Biomedical Signal Processing and Control","issn_l":"1746-8094","issn":["1746-8094","1746-8108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Signal Processing and Control","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bspc.2026.110718","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137027923","display_name":"Albert Croner","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Albert Croner","raw_affiliation_strings":["Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0092-4030","affiliations":[{"raw_affiliation_string":"Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137690440","display_name":"Jonas Geissdoerfer","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jonas Geissdoerfer","raw_affiliation_strings":["Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017261882","display_name":"Siwei Bai","orcid":"https://orcid.org/0000-0002-6805-7244"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siwei Bai","raw_affiliation_strings":["Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6805-7244","affiliations":[{"raw_affiliation_string":"Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137625412","display_name":"Werner Hemmert","orcid":"https://orcid.org/0000-0002-2905-6118"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Hemmert","raw_affiliation_strings":["Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2905-6118","affiliations":[{"raw_affiliation_string":"Bio-Inspired Information Processing, Boltzmannstr. 15, Garching, 85748, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Technical University of Munich, Arcisstr. 21, Munich, 80333, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5137027923"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84131743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":null,"first_page":"110718","last_page":"110718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.8978000283241272,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.8978000283241272,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spiral-ganglion","display_name":"Spiral ganglion","score":0.8805999755859375},{"id":"https://openalex.org/keywords/degeneration","display_name":"Degeneration (medical)","score":0.7232999801635742},{"id":"https://openalex.org/keywords/cochlear-implant","display_name":"Cochlear implant","score":0.6035000085830688},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5339000225067139},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4616999924182892},{"id":"https://openalex.org/keywords/spiral","display_name":"Spiral (railway)","score":0.4413999915122986}],"concepts":[{"id":"https://openalex.org/C2779152698","wikidata":"https://www.wikidata.org/wiki/Q3095145","display_name":"Spiral ganglion","level":3,"score":0.8805999755859375},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.7232999801635742},{"id":"https://openalex.org/C2778882171","wikidata":"https://www.wikidata.org/wiki/Q724965","display_name":"Cochlear implant","level":2,"score":0.6035000085830688},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5339000225067139},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5299999713897705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5004000067710876},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4616999924182892},{"id":"https://openalex.org/C174128100","wikidata":"https://www.wikidata.org/wiki/Q846907","display_name":"Spiral (railway)","level":2,"score":0.4413999915122986},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.424699991941452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3815000057220459},{"id":"https://openalex.org/C2781334511","wikidata":"https://www.wikidata.org/wiki/Q108158","display_name":"Ganglion","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C186565885","wikidata":"https://www.wikidata.org/wiki/Q1651163","display_name":"Biological neuron model","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C2909516373","wikidata":"https://www.wikidata.org/wiki/Q1753825","display_name":"Axonal degeneration","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.2687000036239624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bspc.2026.110718","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bspc.2026.110718","pdf_url":null,"source":{"id":"https://openalex.org/S8427965","display_name":"Biomedical Signal Processing and Control","issn_l":"1746-8094","issn":["1746-8094","1746-8108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Signal Processing and Control","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bspc.2026.110718","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bspc.2026.110718","pdf_url":null,"source":{"id":"https://openalex.org/S8427965","display_name":"Biomedical Signal Processing and Control","issn_l":"1746-8094","issn":["1746-8094","1746-8108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Signal Processing and Control","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.72654789686203,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1831207122","https://openalex.org/W1965208832","https://openalex.org/W1972878945","https://openalex.org/W1973372355","https://openalex.org/W1975616153","https://openalex.org/W1978065279","https://openalex.org/W1982746788","https://openalex.org/W1983922419","https://openalex.org/W1988427051","https://openalex.org/W1989370150","https://openalex.org/W1994355247","https://openalex.org/W1995813389","https://openalex.org/W2015362852","https://openalex.org/W2022857227","https://openalex.org/W2025449195","https://openalex.org/W2033516084","https://openalex.org/W2037976268","https://openalex.org/W2038914534","https://openalex.org/W2041294536","https://openalex.org/W2044921780","https://openalex.org/W2055166265","https://openalex.org/W2058717342","https://openalex.org/W2065209903","https://openalex.org/W2065882547","https://openalex.org/W2069956352","https://openalex.org/W2073673228","https://openalex.org/W2120790466","https://openalex.org/W2145947912","https://openalex.org/W2171236385","https://openalex.org/W2516564121","https://openalex.org/W2741360465","https://openalex.org/W2772119835","https://openalex.org/W2908543115","https://openalex.org/W2991370782","https://openalex.org/W3021104054","https://openalex.org/W3031274383","https://openalex.org/W3031527953","https://openalex.org/W3082250139","https://openalex.org/W3087267723","https://openalex.org/W3102770974","https://openalex.org/W3131189445","https://openalex.org/W3195373245","https://openalex.org/W4286631345","https://openalex.org/W4294100637","https://openalex.org/W4310385666","https://openalex.org/W4388624945","https://openalex.org/W4392580552","https://openalex.org/W4404263799","https://openalex.org/W4409253721","https://openalex.org/W4410050168","https://openalex.org/W4411472209"],"related_works":[],"abstract_inverted_index":{"Cochlear":[0],"implants":[1],"restore":[2],"hearing":[3],"by":[4,13,181],"electrically":[5],"stimulating":[6],"the":[7,55,101,228],"auditory":[8],"nerve,":[9],"but":[10],"are":[11,247],"limited":[12],"broad":[14],"electric":[15,35],"fields.":[16,36],"Multipolar":[17,126],"stimulation,":[18],"such":[19],"as":[20],"bipolar":[21],"(BP)":[22],"and":[23,92,114,123,134,139,153,163,195,200,208,213],"tripolar":[24],"(TP),":[25],"aims":[26],"to":[27,46,58],"reduce":[28],"current":[29,87],"spread,":[30],"thus":[31],"generating":[32],"more":[33,149,172,201],"focused":[34],"Nevertheless,":[37],"multipolar":[38,61,232],"stimulation":[39,62,127,233,240],"has":[40],"not":[41,64,235],"improved":[42],"speech":[43],"understanding":[44],"compared":[45],"monopolar":[47,66,237],"(MP)":[48],"stimulation.":[49,67,238],"We":[50],"used":[51],"computer":[52],"models":[53],"of":[54,95],"human":[56],"cochlea":[57],"investigate":[59],"why":[60,231],"does":[63,234],"outperform":[65,236],"A":[68],"finite":[69],"element":[70],"volume":[71],"conduction":[72],"model,":[73],"based":[74],"on":[75],"a":[76],"high-resolution":[77],"\u03bc":[78,82],"CT":[79],"scan":[80],"(6":[81],"m":[83],"voxel":[84],"size),":[85],"calculated":[86],"spread":[88],"for":[89,121],"MP,":[90,161],"BP,":[91,162],"TP.":[93],"Excitation":[94,117],"400":[96],"spiral":[97,221],"ganglion":[98,222],"neurons":[99],"along":[100],"tonotopic":[102,124],"axis":[103],"was":[104,147,170],"simulated":[105],"with":[106,110,128,142,190,243,249],"biophysical":[107],"multi-compartment":[108],"models,":[109],"dendrites":[111,130],"in":[112],"intact":[113,129,191,244],"degenerated":[115,159,205],"states.":[116],"patterns":[118],"were":[119,165],"analyzed":[120],"focality":[122],"accuracy.":[125],"often":[131],"generated":[132],"bi-":[133],"trimodal":[135],"excitation":[136],"near":[137],"active":[138],"return":[140],"electrodes,":[141],"gaps":[143],"between":[144],"them.":[145],"TP":[146,164,187,209,239],"generally":[148],"focal":[150,173],"than":[151],"BP":[152,196,207],"MP":[154,169,194,214],"despite":[155],"this":[156],"pattern.":[157],"With":[158,204],"dendrites,":[160,192,206,245],"similarly":[166],"focal,":[167],"though":[168],"slightly":[171],"at":[174],"high":[175],"stimulus":[176],"levels.":[177],"Tonotopic":[178],"accuracy,":[179],"quantified":[180],"place":[182],"pitch":[183,188,198,211,217],"centroid,":[184],"showed":[185],"appropriate":[186],"progression":[189],"while":[193],"exhibited":[197],"confusion":[199],"irregular":[202],"patterns.":[203],"included":[210],"reversal,":[212],"displayed":[215],"increased":[216],"confusion.":[218],"In":[219],"conclusion,":[220],"neuron":[223],"dendrite":[224],"degeneration":[225],"is":[226],"likely":[227],"primary":[229],"reason":[230],"offers":[241],"advantages":[242],"which":[246],"lost":[248],"degeneration.":[250]},"counts_by_year":[],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2026-06-03T00:00:00"}