{"id":"https://openalex.org/W7147189012","doi":"https://doi.org/10.1016/j.bspc.2026.110215","title":"Deep learning bridges histopathology and molecular profiling: An integrated framework for improved mutation prediction and biological interpretation: A multi-cohort study","display_name":"Deep learning bridges histopathology and molecular profiling: An integrated framework for improved mutation prediction and biological interpretation: A multi-cohort study","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7147189012","doi":"https://doi.org/10.1016/j.bspc.2026.110215"},"language":"en","primary_location":{"id":"doi:10.1016/j.bspc.2026.110215","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bspc.2026.110215","pdf_url":null,"source":{"id":"https://openalex.org/S8427965","display_name":"Biomedical Signal Processing and Control","issn_l":"1746-8094","issn":["1746-8094","1746-8108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Signal Processing and Control","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103323874","display_name":"Shengli Shao","orcid":"https://orcid.org/0000-0001-8786-0051"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengli Shao","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128823281","display_name":"Wenhui Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhui Shen","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132570867","display_name":"Chunmiao Han","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunmiao Han","raw_affiliation_strings":["Department of Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132701365","display_name":"Gang Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047158702","display_name":"J.H. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiheng Wang","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362780","display_name":"Xiaojun Zhang","orcid":"https://orcid.org/0000-0002-0304-0003"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Zhang","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062394564","display_name":"Qigen Fang","orcid":"https://orcid.org/0000-0002-7303-1030"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qigen Fang","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126185255","display_name":"J. Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfu Wu","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132697661","display_name":"Ruihua Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruihua Luo","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416807","display_name":"Yanyan Liu","orcid":"https://orcid.org/0000-0001-9707-2083"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Liu","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076073231","display_name":"Meng Cui","orcid":"https://orcid.org/0000-0002-6337-9711"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanyan Liu","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132622762","display_name":"Wei Du","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Cui","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128405695","display_name":"S T Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shanting Liu","orcid":"https://orcid.org/0009-0000-9402-4908"},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shanting Liu","raw_affiliation_strings":["Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China"],"raw_orcid":"https://orcid.org/0009-0000-9402-4908","affiliations":[{"raw_affiliation_string":"Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China","institution_ids":["https://openalex.org/I4210143608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076073231"],"corresponding_institution_ids":["https://openalex.org/I4210143608"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4069839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":null,"first_page":"110215","last_page":"110215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9714000225067139,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9714000225067139,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6549000144004822},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.611299991607666},{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.5041999816894531},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4796999990940094},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.47099998593330383},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4124999940395355},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.3855000138282776},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.3578000068664551}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6807000041007996},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6437000036239624},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.611299991607666},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5041999816894531},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4796999990940094},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4124999940395355},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3578000068664551},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.35359999537467957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3522000014781952},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.3375999927520752},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.3285999894142151},{"id":"https://openalex.org/C83665646","wikidata":"https://www.wikidata.org/wiki/Q42139305","display_name":"Feature vector","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.296999990940094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2709999978542328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25589999556541443},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bspc.2026.110215","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bspc.2026.110215","pdf_url":null,"source":{"id":"https://openalex.org/S8427965","display_name":"Biomedical Signal Processing and Control","issn_l":"1746-8094","issn":["1746-8094","1746-8108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Signal Processing and Control","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2343160907","https://openalex.org/W2615702226","https://openalex.org/W2623594410","https://openalex.org/W2760946358","https://openalex.org/W2771542157","https://openalex.org/W2948930564","https://openalex.org/W2949243209","https://openalex.org/W2964317695","https://openalex.org/W2967444033","https://openalex.org/W3000311037","https://openalex.org/W3017173206","https://openalex.org/W3044996171","https://openalex.org/W3115168802","https://openalex.org/W3133711868","https://openalex.org/W3190202966","https://openalex.org/W3205605830","https://openalex.org/W3212752056","https://openalex.org/W3213490135","https://openalex.org/W3213545705","https://openalex.org/W4206207828","https://openalex.org/W4224016686","https://openalex.org/W4224227775","https://openalex.org/W4283032464","https://openalex.org/W4283805541","https://openalex.org/W4307843508","https://openalex.org/W4309821851","https://openalex.org/W4317866015","https://openalex.org/W4360999347","https://openalex.org/W4382561738","https://openalex.org/W4386303561","https://openalex.org/W4389839624","https://openalex.org/W4392947532","https://openalex.org/W4394564094","https://openalex.org/W4394621473","https://openalex.org/W4398201291","https://openalex.org/W4398250457","https://openalex.org/W4400294055","https://openalex.org/W4400889241","https://openalex.org/W4402220065","https://openalex.org/W4403606287","https://openalex.org/W4405094241"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2026-04-02T00:00:00"}
