{"id":"https://openalex.org/W7164030005","doi":"https://doi.org/10.1016/j.biosystems.2026.105850","title":"The central homeorhetic principle: Lipid-organized boundary systems as constraints on cellular state realization","display_name":"The central homeorhetic principle: Lipid-organized boundary systems as constraints on cellular state realization","publication_year":2026,"publication_date":"2026-06-09","ids":{"openalex":"https://openalex.org/W7164030005","doi":"https://doi.org/10.1016/j.biosystems.2026.105850","pmid":"https://pubmed.ncbi.nlm.nih.gov/42263901"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2026.105850","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105850","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027440104","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0003-3873-7350"},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province, 213164, China. Electronic address: wangc90@cczu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-3873-7350","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province, 213164, China. Electronic address: wangc90@cczu.edu.cn","institution_ids":["https://openalex.org/I4210153482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027440104"],"corresponding_institution_ids":["https://openalex.org/I4210153482"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69559556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"266","issue":null,"first_page":"105850","last_page":"105850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6295999884605408,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6295999884605408,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.10010000318288803,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/realization","display_name":"Realization (probability)","score":0.7641000151634216},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.6442000269889832},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.5684000253677368},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5246999859809875},{"id":"https://openalex.org/keywords/boundary-value-problem","display_name":"Boundary value problem","score":0.4097000062465668}],"concepts":[{"id":"https://openalex.org/C2781089630","wikidata":"https://www.wikidata.org/wiki/Q21856745","display_name":"Realization (probability)","level":2,"score":0.7641000151634216},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.6442000269889832},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.5684000253677368},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5246999859809875},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4717999994754791},{"id":"https://openalex.org/C182310444","wikidata":"https://www.wikidata.org/wiki/Q1332643","display_name":"Boundary value problem","level":2,"score":0.4097000062465668},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4036000072956085},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.35530000925064087},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.349700003862381},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3100999891757965},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.28929999470710754},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.2587999999523163}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2026.105850","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105850","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:42263901","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42263901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.43711379170417786,"display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1644749979","https://openalex.org/W1720193968","https://openalex.org/W1875710910","https://openalex.org/W1970779075","https://openalex.org/W1971108880","https://openalex.org/W1975024842","https://openalex.org/W1981748148","https://openalex.org/W1986606329","https://openalex.org/W1999720993","https://openalex.org/W2000966264","https://openalex.org/W2014809850","https://openalex.org/W2025522134","https://openalex.org/W2028932050","https://openalex.org/W2030214706","https://openalex.org/W2040176672","https://openalex.org/W2041042514","https://openalex.org/W2047115921","https://openalex.org/W2048094578","https://openalex.org/W2050285934","https://openalex.org/W2052800549","https://openalex.org/W2054342311","https://openalex.org/W2054352933","https://openalex.org/W2055214702","https://openalex.org/W2057250255","https://openalex.org/W2072167784","https://openalex.org/W2072319015","https://openalex.org/W2077996001","https://openalex.org/W2080484884","https://openalex.org/W2089114542","https://openalex.org/W2091884933","https://openalex.org/W2093020640","https://openalex.org/W2098549100","https://openalex.org/W2107475155","https://openalex.org/W2114870653","https://openalex.org/W2125872855","https://openalex.org/W2127234404","https://openalex.org/W2134208433","https://openalex.org/W2137124858","https://openalex.org/W2139064489","https://openalex.org/W2141545875","https://openalex.org/W2145080853","https://openalex.org/W2151659911","https://openalex.org/W2157989234","https://openalex.org/W2161435888","https://openalex.org/W2163480486","https://openalex.org/W2163802608","https://openalex.org/W2167031279","https://openalex.org/W2171832928","https://openalex.org/W2187985754","https://openalex.org/W2269679925","https://openalex.org/W2335345046","https://openalex.org/W2463708289","https://openalex.org/W2553725030","https://openalex.org/W2555705980","https://openalex.org/W2590568317","https://openalex.org/W2767055857","https://openalex.org/W2809057270","https://openalex.org/W2809092342","https://openalex.org/W2924515523","https://openalex.org/W3023669232","https://openalex.org/W3127174478","https://openalex.org/W4211017114","https://openalex.org/W4235033012","https://openalex.org/W4253687499","https://openalex.org/W4255760236","https://openalex.org/W4362457999","https://openalex.org/W4368341559","https://openalex.org/W4383341351","https://openalex.org/W4389900120","https://openalex.org/W4393280006","https://openalex.org/W4394727212","https://openalex.org/W4404978008","https://openalex.org/W4411629460","https://openalex.org/W4413116398","https://openalex.org/W4413759686","https://openalex.org/W4417151946"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2026-06-10T00:00:00"}
