{"id":"https://openalex.org/W7154836373","doi":"https://doi.org/10.1016/j.biosystems.2026.105792","title":"Access denied: Plato's cave and the epistemic limits of cellular life","display_name":"Access denied: Plato's cave and the epistemic limits of cellular life","publication_year":2026,"publication_date":"2026-04-18","ids":{"openalex":"https://openalex.org/W7154836373","doi":"https://doi.org/10.1016/j.biosystems.2026.105792","pmid":"https://pubmed.ncbi.nlm.nih.gov/42009120"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2026.105792","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105792","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083098413","display_name":"William B. Miller","orcid":"https://orcid.org/0000-0003-1661-5416"},"institutions":[{"id":"https://openalex.org/I2802412784","display_name":"Banner Health","ror":"https://ror.org/039wwwz66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802412784"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William B. Miller","raw_affiliation_strings":["Banner Health Systems, Paradise Valley, AZ, United States. Electronic address: wbmiller1@cox.net"],"raw_orcid":"https://orcid.org/0000-0003-1661-5416","affiliations":[{"raw_affiliation_string":"Banner Health Systems, Paradise Valley, AZ, United States. Electronic address: wbmiller1@cox.net","institution_ids":["https://openalex.org/I2802412784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030222127","display_name":"Predrag Slijep\u010devi\u0107","orcid":"https://orcid.org/0000-0003-0168-3598"},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Predrag Slijep\u010devi\u0107","raw_affiliation_strings":["Department of Life Sciences, College of Health, Medicine and Life Sciences, University of Brunel, UK. Electronic address: Predrag.Slijepcevic@brunel.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, College of Health, Medicine and Life Sciences, University of Brunel, UK. Electronic address: Predrag.Slijepcevic@brunel.ac.uk","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133956827","display_name":"Franti\u0161ek Balu\u0161ka","orcid":null},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franti\u0161ek Balu\u0161ka","raw_affiliation_strings":["Institute of Cellular and Molecular Botany, University of Bonn, Germany. Electronic address: baluska@uni-bonn.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and Molecular Botany, University of Bonn, Germany. Electronic address: baluska@uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083098413"],"corresponding_institution_ids":["https://openalex.org/I2802412784"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":7.8109,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96827646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"265","issue":null,"first_page":"105792","last_page":"105792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.6171000003814697,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.6171000003814697,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11883","display_name":"Embodied and Extended Cognition","score":0.07410000264644623,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/living-systems","display_name":"Living systems","score":0.6628999710083008},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.503600001335144},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.4674000144004822},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.4490000009536743},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.37439998984336853},{"id":"https://openalex.org/keywords/subject","display_name":"Subject (documents)","score":0.3368000090122223},{"id":"https://openalex.org/keywords/quantum-entanglement","display_name":"Quantum entanglement","score":0.3249000012874603}],"concepts":[{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.6628999710083008},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.5045999884605408},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.503600001335144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47769999504089355},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.4490000009536743},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C2777855551","wikidata":"https://www.wikidata.org/wiki/Q12310021","display_name":"Subject (documents)","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C121040770","wikidata":"https://www.wikidata.org/wiki/Q215675","display_name":"Quantum entanglement","level":3,"score":0.3249000012874603},{"id":"https://openalex.org/C2992918937","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Biological organism","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C113336015","wikidata":"https://www.wikidata.org/wiki/Q574010","display_name":"Complete information","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C34048319","wikidata":"https://www.wikidata.org/wiki/Q599967","display_name":"Autopoiesis","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.29490000009536743},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C19273510","wikidata":"https://www.wikidata.org/wiki/Q263847","display_name":"Artificial life","level":2,"score":0.2590999901294708}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059552","descriptor_name":"Caves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2026.105792","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105792","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:42009120","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42009120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W87274109","https://openalex.org/W857703846","https://openalex.org/W1141585881","https://openalex.org/W1528822345","https://openalex.org/W1590951841","https://openalex.org/W1920095995","https://openalex.org/W1969067512","https://openalex.org/W1995717740","https://openalex.org/W1995875735","https://openalex.org/W2005886497","https://openalex.org/W2013259421","https://openalex.org/W2017446028","https://openalex.org/W2021058886","https://openalex.org/W2054791977","https://openalex.org/W2055789905","https://openalex.org/W2069486527","https://openalex.org/W2082080810","https://openalex.org/W2103185622","https://openalex.org/W2111030512","https://openalex.org/W2120277394","https://openalex.org/W2123834061","https://openalex.org/W2145022888","https://openalex.org/W2145024737","https://openalex.org/W2148764920","https://openalex.org/W2150320598","https://openalex.org/W2155505956","https://openalex.org/W2158746679","https://openalex.org/W2158935941","https://openalex.org/W2163886718","https://openalex.org/W2169465475","https://openalex.org/W2181423991","https://openalex.org/W2331484950","https://openalex.org/W2397687625","https://openalex.org/W2513121791","https://openalex.org/W2579922155","https://openalex.org/W2591991211","https://openalex.org/W2637360448","https://openalex.org/W2736762342","https://openalex.org/W2779359918","https://openalex.org/W2783143438","https://openalex.org/W2896037961","https://openalex.org/W2914463176","https://openalex.org/W2945567094","https://openalex.org/W2968415284","https://openalex.org/W2972066676","https://openalex.org/W2975760833","https://openalex.org/W2988114478","https://openalex.org/W3005868053","https://openalex.org/W3008358844","https://openalex.org/W3015289636","https://openalex.org/W3025252647","https://openalex.org/W3045624709","https://openalex.org/W3099576249","https://openalex.org/W3109945601","https://openalex.org/W3116573416","https://openalex.org/W3123874034","https://openalex.org/W3134479834","https://openalex.org/W3154411924","https://openalex.org/W3155348911","https://openalex.org/W3158145963","https://openalex.org/W3159836698","https://openalex.org/W3171803253","https://openalex.org/W3214728447","https://openalex.org/W4205379676","https://openalex.org/W4210749031","https://openalex.org/W4214942036","https://openalex.org/W4221100621","https://openalex.org/W4233798822","https://openalex.org/W4239860474","https://openalex.org/W4280580807","https://openalex.org/W4297522814","https://openalex.org/W4368371426","https://openalex.org/W4376135376","https://openalex.org/W4377101719","https://openalex.org/W4379013098","https://openalex.org/W4382344442","https://openalex.org/W4383105633","https://openalex.org/W4385679502","https://openalex.org/W4386055174","https://openalex.org/W4387691882","https://openalex.org/W4387783011","https://openalex.org/W4388299828","https://openalex.org/W4388691926","https://openalex.org/W4388871055","https://openalex.org/W4389941048","https://openalex.org/W4390036204","https://openalex.org/W4390277816","https://openalex.org/W4391508887","https://openalex.org/W4393307053","https://openalex.org/W4394777513","https://openalex.org/W4396836014","https://openalex.org/W4399223951","https://openalex.org/W4404447898","https://openalex.org/W4405862004","https://openalex.org/W4407610334","https://openalex.org/W4408167729","https://openalex.org/W4408896211","https://openalex.org/W4408929309","https://openalex.org/W4413116398","https://openalex.org/W4413285430","https://openalex.org/W4414744503","https://openalex.org/W4414947862","https://openalex.org/W4416009194","https://openalex.org/W7135052351"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-05-11T06:02:39.374780","created_date":"2026-04-19T00:00:00"}
