{"id":"https://openalex.org/W7139058211","doi":"https://doi.org/10.1016/j.biosystems.2026.105774","title":"Flux organizations and control modes in antagonistically combined negative feedback loops","display_name":"Flux organizations and control modes in antagonistically combined negative feedback loops","publication_year":2026,"publication_date":"2026-03-19","ids":{"openalex":"https://openalex.org/W7139058211","doi":"https://doi.org/10.1016/j.biosystems.2026.105774","pmid":"https://pubmed.ncbi.nlm.nih.gov/41864489"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2026.105774","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105774","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070276219","display_name":"Peter Ruoff","orcid":"https://orcid.org/0000-0003-4430-0382"},"institutions":[{"id":"https://openalex.org/I92008406","display_name":"University of Stavanger","ror":"https://ror.org/02qte9q33","country_code":"NO","type":"education","lineage":["https://openalex.org/I92008406"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Peter Ruoff","raw_affiliation_strings":["University of Stavanger, Department of Chemistry, Bioscience, and Environmental Engineering, Kjell Arholms gate 41, Stavanger, 4021, Rogaland, Norway. Electronic address: ruoff@ux.uis.no"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Stavanger, Department of Chemistry, Bioscience, and Environmental Engineering, Kjell Arholms gate 41, Stavanger, 4021, Rogaland, Norway. Electronic address: ruoff@ux.uis.no","institution_ids":["https://openalex.org/I92008406"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070276219"],"corresponding_institution_ids":["https://openalex.org/I92008406"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48822527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"263","issue":null,"first_page":"105774","last_page":"105774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.30309998989105225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.30309998989105225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setpoint","display_name":"Setpoint","score":0.9908999800682068},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.8884000182151794},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.6668000221252441},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.6176999807357788},{"id":"https://openalex.org/keywords/variable","display_name":"Variable (mathematics)","score":0.5568000078201294},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5521000027656555},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5184999704360962},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4832000136375427},{"id":"https://openalex.org/keywords/autoregulation","display_name":"Autoregulation","score":0.45399999618530273},{"id":"https://openalex.org/keywords/metastability","display_name":"Metastability","score":0.44339999556541443}],"concepts":[{"id":"https://openalex.org/C12302492","wikidata":"https://www.wikidata.org/wiki/Q1752097","display_name":"Setpoint","level":2,"score":0.9908999800682068},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.8884000182151794},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.6668000221252441},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.6176999807357788},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.5568000078201294},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5521000027656555},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5184999704360962},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4832000136375427},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.45399999618530273},{"id":"https://openalex.org/C89464430","wikidata":"https://www.wikidata.org/wiki/Q849516","display_name":"Metastability","level":2,"score":0.44339999556541443},{"id":"https://openalex.org/C153240184","wikidata":"https://www.wikidata.org/wiki/Q3243772","display_name":"Control variable","level":2,"score":0.42419999837875366},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C3018623182","wikidata":"https://www.wikidata.org/wiki/Q154021","display_name":"Output feedback","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35429999232292175},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35190001130104065},{"id":"https://openalex.org/C28427503","wikidata":"https://www.wikidata.org/wiki/Q13580300","display_name":"Internal model","level":3,"score":0.34310001134872437},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C3017962763","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Feedback regulation","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2964000105857849},{"id":"https://openalex.org/C167964875","wikidata":"https://www.wikidata.org/wiki/Q17011487","display_name":"Exponential stability","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2766999900341034},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.2635999917984009},{"id":"https://openalex.org/C162838799","wikidata":"https://www.wikidata.org/wiki/Q596077","display_name":"Counterexample","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C167123822","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automatic control","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C48677424","wikidata":"https://www.wikidata.org/wiki/Q6888088","display_name":"Mode (computer interface)","level":2,"score":0.2524999976158142}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017111","descriptor_name":"Phodopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017440","descriptor_name":"Photoperiod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2026.105774","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105774","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:41864489","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41864489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.44832944869995117,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1480583769","https://openalex.org/W1533618603","https://openalex.org/W1576664335","https://openalex.org/W1964827644","https://openalex.org/W1968414492","https://openalex.org/W1974327486","https://openalex.org/W1979385177","https://openalex.org/W1991932257","https://openalex.org/W1998984241","https://openalex.org/W2003790211","https://openalex.org/W2003866008","https://openalex.org/W2023008210","https://openalex.org/W2037906405","https://openalex.org/W2043471584","https://openalex.org/W2046649943","https://openalex.org/W2053345816","https://openalex.org/W2055621713","https://openalex.org/W2056861732","https://openalex.org/W2066718612","https://openalex.org/W2073208447","https://openalex.org/W2087538969","https://openalex.org/W2098825026","https://openalex.org/W2099648444","https://openalex.org/W2112509178","https://openalex.org/W2117056464","https://openalex.org/W2133254839","https://openalex.org/W2135415852","https://openalex.org/W2163617636","https://openalex.org/W2266355581","https://openalex.org/W2317320159","https://openalex.org/W2472786230","https://openalex.org/W2621089939","https://openalex.org/W2801204143","https://openalex.org/W2801823793","https://openalex.org/W2802389030","https://openalex.org/W2939796484","https://openalex.org/W2952738056","https://openalex.org/W2952908870","https://openalex.org/W2964989731","https://openalex.org/W3010983921","https://openalex.org/W3012033770","https://openalex.org/W3027759701","https://openalex.org/W3169086554","https://openalex.org/W3217417991","https://openalex.org/W4211045533","https://openalex.org/W4366581729","https://openalex.org/W4378746475","https://openalex.org/W4384297741","https://openalex.org/W4386215514","https://openalex.org/W4390706998","https://openalex.org/W4400283076","https://openalex.org/W4401827612","https://openalex.org/W4408652663","https://openalex.org/W4415706476","https://openalex.org/W7117679766"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2026-03-20T00:00:00"}
