{"id":"https://openalex.org/W7131663309","doi":"https://doi.org/10.1016/j.biosystems.2026.105738","title":"Clock rate and controllable volume: Physical constraints on biological pacemakers without assuming metabolic scaling","display_name":"Clock rate and controllable volume: Physical constraints on biological pacemakers without assuming metabolic scaling","publication_year":2026,"publication_date":"2026-02-26","ids":{"openalex":"https://openalex.org/W7131663309","doi":"https://doi.org/10.1016/j.biosystems.2026.105738","pmid":"https://pubmed.ncbi.nlm.nih.gov/41763633"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2026.105738","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105738","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072214554","display_name":"Tatsuaki Tsuruyama","orcid":"https://orcid.org/0000-0002-3118-2826"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuaki Tsuruyama","raw_affiliation_strings":["Department of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Department of Clinical Laboratory Medicine, Graduate School of Health Science, Kyoto Tachibana University, Kyoto 607-8175, Japan. Electronic address: tsuruyam@kuhp.kyoto-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-3118-2826","affiliations":[{"raw_affiliation_string":"Department of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Department of Clinical Laboratory Medicine, Graduate School of Health Science, Kyoto Tachibana University, Kyoto 607-8175, Japan. Electronic address: tsuruyam@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072214554"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35830013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"262","issue":null,"first_page":"105738","last_page":"105738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scaling","display_name":"Scaling","score":0.8224999904632568},{"id":"https://openalex.org/keywords/allometry","display_name":"Allometry","score":0.6656000018119812},{"id":"https://openalex.org/keywords/exponent","display_name":"Exponent","score":0.6180999875068665},{"id":"https://openalex.org/keywords/upper-and-lower-bounds","display_name":"Upper and lower bounds","score":0.5309000015258789},{"id":"https://openalex.org/keywords/hurst-exponent","display_name":"Hurst exponent","score":0.4767000079154968},{"id":"https://openalex.org/keywords/dimension","display_name":"Dimension (graph theory)","score":0.42739999294281006},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.4253999888896942},{"id":"https://openalex.org/keywords/fractal","display_name":"Fractal","score":0.4034999907016754},{"id":"https://openalex.org/keywords/l\u00e9vy-flight","display_name":"L\u00e9vy flight","score":0.3801000118255615}],"concepts":[{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.8224999904632568},{"id":"https://openalex.org/C153026981","wikidata":"https://www.wikidata.org/wiki/Q519888","display_name":"Allometry","level":2,"score":0.6656000018119812},{"id":"https://openalex.org/C2780388253","wikidata":"https://www.wikidata.org/wiki/Q5421508","display_name":"Exponent","level":2,"score":0.6180999875068665},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5338000059127808},{"id":"https://openalex.org/C77553402","wikidata":"https://www.wikidata.org/wiki/Q13222579","display_name":"Upper and lower bounds","level":2,"score":0.5309000015258789},{"id":"https://openalex.org/C96835011","wikidata":"https://www.wikidata.org/wiki/Q1638718","display_name":"Hurst exponent","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.43149998784065247},{"id":"https://openalex.org/C33676613","wikidata":"https://www.wikidata.org/wiki/Q13415176","display_name":"Dimension (graph theory)","level":2,"score":0.42739999294281006},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C40636538","wikidata":"https://www.wikidata.org/wiki/Q81392","display_name":"Fractal","level":2,"score":0.4034999907016754},{"id":"https://openalex.org/C118918019","wikidata":"https://www.wikidata.org/wiki/Q4114998","display_name":"L\u00e9vy flight","level":3,"score":0.3801000118255615},{"id":"https://openalex.org/C173801870","wikidata":"https://www.wikidata.org/wiki/Q201413","display_name":"Heuristic","level":2,"score":0.3772999942302704},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C2778067643","wikidata":"https://www.wikidata.org/wiki/Q166507","display_name":"Interval (graph theory)","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C26546657","wikidata":"https://www.wikidata.org/wiki/Q1412452","display_name":"Fractal dimension","level":3,"score":0.35830000042915344},{"id":"https://openalex.org/C87040749","wikidata":"https://www.wikidata.org/wiki/Q428971","display_name":"Power law","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C191544260","wikidata":"https://www.wikidata.org/wiki/Q1238630","display_name":"Lyapunov exponent","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.32280001044273376},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2630999982357025},{"id":"https://openalex.org/C21689155","wikidata":"https://www.wikidata.org/wiki/Q2451452","display_name":"Detrended fluctuation analysis","level":3,"score":0.2572999894618988}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049628","descriptor_name":"Body Size","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2026.105738","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2026.105738","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:41763633","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41763633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.5965211391448975,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1480260620","https://openalex.org/W1986487261","https://openalex.org/W2021677188","https://openalex.org/W2031770486","https://openalex.org/W2044282244","https://openalex.org/W2045600218","https://openalex.org/W2060289244","https://openalex.org/W2065985000","https://openalex.org/W2080843536","https://openalex.org/W2086587185","https://openalex.org/W2102804857","https://openalex.org/W2102917242","https://openalex.org/W2112912140","https://openalex.org/W2113231609","https://openalex.org/W2131968791","https://openalex.org/W2139755242","https://openalex.org/W2160477811","https://openalex.org/W2160524286","https://openalex.org/W2161570633","https://openalex.org/W2163465871","https://openalex.org/W2168847543","https://openalex.org/W2315015718","https://openalex.org/W2525122975","https://openalex.org/W3168498344","https://openalex.org/W3199379162","https://openalex.org/W4306833913","https://openalex.org/W4379377020","https://openalex.org/W4408003917","https://openalex.org/W4409096962"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-05-07T06:04:25.777469","created_date":"2026-02-27T00:00:00"}