{"id":"https://openalex.org/W4396669576","doi":"https://doi.org/10.1016/j.biosystems.2024.105227","title":"Temporal multiscale modeling of biochemical regulatory networks: Calcium-regulated hepatocyte lipid and glucose metabolism","display_name":"Temporal multiscale modeling of biochemical regulatory networks: Calcium-regulated hepatocyte lipid and glucose metabolism","publication_year":2024,"publication_date":"2024-05-06","ids":{"openalex":"https://openalex.org/W4396669576","doi":"https://doi.org/10.1016/j.biosystems.2024.105227","pmid":"https://pubmed.ncbi.nlm.nih.gov/38718915"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2024.105227","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105227","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088036560","display_name":"Arina V. Martyshina","orcid":"https://orcid.org/0000-0002-1470-6704"},"institutions":[{"id":"https://openalex.org/I4210156304","display_name":"Sarov Institute of Physics and Technology","ror":"https://ror.org/05e94de73","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]},{"id":"https://openalex.org/I887846188","display_name":"National Research Nuclear University MEPhI","ror":"https://ror.org/04w8z7f34","country_code":"RU","type":"education","lineage":["https://openalex.org/I887846188"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Arina V. Martyshina","raw_affiliation_strings":["Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-1470-6704","affiliations":[{"raw_affiliation_string":"Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation","institution_ids":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061035693","display_name":"A. G. Sirotkina","orcid":"https://orcid.org/0000-0003-4559-7763"},"institutions":[{"id":"https://openalex.org/I4210156304","display_name":"Sarov Institute of Physics and Technology","ror":"https://ror.org/05e94de73","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]},{"id":"https://openalex.org/I887846188","display_name":"National Research Nuclear University MEPhI","ror":"https://ror.org/04w8z7f34","country_code":"RU","type":"education","lineage":["https://openalex.org/I887846188"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna G. Sirotkina","raw_affiliation_strings":["Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0003-4559-7763","affiliations":[{"raw_affiliation_string":"Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation","institution_ids":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027635666","display_name":"Irina V. Gosteva","orcid":"https://orcid.org/0000-0001-6302-952X"},"institutions":[{"id":"https://openalex.org/I4210156304","display_name":"Sarov Institute of Physics and Technology","ror":"https://ror.org/05e94de73","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]},{"id":"https://openalex.org/I887846188","display_name":"National Research Nuclear University MEPhI","ror":"https://ror.org/04w8z7f34","country_code":"RU","type":"education","lineage":["https://openalex.org/I887846188"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Irina V. Gosteva","raw_affiliation_strings":["Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation. Electronic address: irinavgosteva@gmail.com","Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-6302-952X","affiliations":[{"raw_affiliation_string":"Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation. Electronic address: irinavgosteva@gmail.com","institution_ids":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]},{"raw_affiliation_string":"Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation","institution_ids":["https://openalex.org/I4210156304","https://openalex.org/I887846188"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027635666"],"corresponding_institution_ids":["https://openalex.org/I4210156304","https://openalex.org/I887846188"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.4281,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61485797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"240","issue":null,"first_page":"105227","last_page":"105227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte","display_name":"Hepatocyte","score":0.6906287670135498},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.642339825630188},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"Lipid metabolism","score":0.5499420762062073},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"Carbohydrate metabolism","score":0.5168641209602356},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.50126051902771},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5011012554168701},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.4832787811756134},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4664214551448822},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33871790766716003},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3243522644042969}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6906287670135498},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.642339825630188},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5499420762062073},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5168641209602356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.50126051902771},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5011012554168701},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4832787811756134},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4664214551448822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33871790766716003},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3243522644042969},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2024.105227","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105227","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:38718915","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38718915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W630286444","https://openalex.org/W1584798972","https://openalex.org/W1968043238","https://openalex.org/W1969067437","https://openalex.org/W1970107333","https://openalex.org/W1988521879","https://openalex.org/W1989693586","https://openalex.org/W1993579534","https://openalex.org/W1999617321","https://openalex.org/W2000465833","https://openalex.org/W2003582307","https://openalex.org/W2006338283","https://openalex.org/W2008479138","https://openalex.org/W2009839577","https://openalex.org/W2016479661","https://openalex.org/W2019692827","https://openalex.org/W2032840033","https://openalex.org/W2042041788","https://openalex.org/W2046120487","https://openalex.org/W2055284866","https://openalex.org/W2058177425","https://openalex.org/W2067094344","https://openalex.org/W2085181720","https://openalex.org/W2090932822","https://openalex.org/W2091330563","https://openalex.org/W2103950919","https://openalex.org/W2109302907","https://openalex.org/W2112509178","https://openalex.org/W2129777218","https://openalex.org/W2131635217","https://openalex.org/W2168942083","https://openalex.org/W2171437709","https://openalex.org/W2230222215","https://openalex.org/W2276342667","https://openalex.org/W2283843704","https://openalex.org/W2291464422","https://openalex.org/W2325076316","https://openalex.org/W2344525015","https://openalex.org/W2522590448","https://openalex.org/W2586256972","https://openalex.org/W2782248454","https://openalex.org/W2895834165","https://openalex.org/W2899043265","https://openalex.org/W2969714550","https://openalex.org/W2970596022","https://openalex.org/W2972900754","https://openalex.org/W2978195092","https://openalex.org/W3013554928","https://openalex.org/W3088519211","https://openalex.org/W3136254756","https://openalex.org/W3146311895","https://openalex.org/W3158145137","https://openalex.org/W3202687206","https://openalex.org/W4311904492","https://openalex.org/W4312257920","https://openalex.org/W4313156542","https://openalex.org/W6642785490","https://openalex.org/W6733404344","https://openalex.org/W6794457257","https://openalex.org/W6847355555","https://openalex.org/W6848200432","https://openalex.org/W7075693086"],"related_works":["https://openalex.org/W2062720478","https://openalex.org/W2412024818","https://openalex.org/W2098332542","https://openalex.org/W1980130043","https://openalex.org/W1984320810","https://openalex.org/W1964662291","https://openalex.org/W2468743120","https://openalex.org/W2417572233","https://openalex.org/W2040370458","https://openalex.org/W2401598822"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
