{"id":"https://openalex.org/W4396747691","doi":"https://doi.org/10.1016/j.biosystems.2024.105226","title":"The cell as a semiotic system that realizes closure to efficient causation: The semiotic (M, R) system","display_name":"The cell as a semiotic system that realizes closure to efficient causation: The semiotic (M, R) system","publication_year":2024,"publication_date":"2024-05-08","ids":{"openalex":"https://openalex.org/W4396747691","doi":"https://doi.org/10.1016/j.biosystems.2024.105226","pmid":"https://pubmed.ncbi.nlm.nih.gov/38723994"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2024.105226","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105226","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.biosystems.2024.105226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065880031","display_name":"Federico Vega","orcid":"https://orcid.org/0000-0002-8301-7187"},"institutions":[{"id":"https://openalex.org/I178450904","display_name":"Universidad Nacional de Educaci\u00f3n a Distancia","ror":"https://ror.org/02msb5n36","country_code":"ES","type":"education","lineage":["https://openalex.org/I178450904"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Federico Vega","raw_affiliation_strings":["Department of Logic, History and Philosophy of Science, National Distance Education University (UNED), Spain. Electronic address: federico.vega@invi.uned.es","Department of Logic, History and Philosophy of Science, National Distance Education University (UNED) \u2013 Spain"],"affiliations":[{"raw_affiliation_string":"Department of Logic, History and Philosophy of Science, National Distance Education University (UNED), Spain. Electronic address: federico.vega@invi.uned.es","institution_ids":["https://openalex.org/I178450904"]},{"raw_affiliation_string":"Department of Logic, History and Philosophy of Science, National Distance Education University (UNED) \u2013 Spain","institution_ids":["https://openalex.org/I178450904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065880031"],"corresponding_institution_ids":["https://openalex.org/I178450904"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":1.6607,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.82626485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"240","issue":null,"first_page":"105226","last_page":"105226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9749000072479248,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9695000052452087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semiotics","display_name":"Semiotics","score":0.9541233777999878},{"id":"https://openalex.org/keywords/closure","display_name":"Closure (psychology)","score":0.7637903094291687},{"id":"https://openalex.org/keywords/causation","display_name":"Causation","score":0.7440022230148315},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5322838425636292},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4737449586391449},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.4437016546726227},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.39091649651527405},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.38494306802749634},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.24985811114311218},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23925650119781494},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.2145131528377533},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20952355861663818}],"concepts":[{"id":"https://openalex.org/C139997677","wikidata":"https://www.wikidata.org/wiki/Q60195","display_name":"Semiotics","level":2,"score":0.9541233777999878},{"id":"https://openalex.org/C146834321","wikidata":"https://www.wikidata.org/wiki/Q2979672","display_name":"Closure (psychology)","level":2,"score":0.7637903094291687},{"id":"https://openalex.org/C166151441","wikidata":"https://www.wikidata.org/wiki/Q4923601","display_name":"Causation","level":2,"score":0.7440022230148315},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5322838425636292},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4737449586391449},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4437016546726227},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.39091649651527405},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.38494306802749634},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.24985811114311218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23925650119781494},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.2145131528377533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20952355861663818},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biosystems.2024.105226","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105226","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:38723994","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38723994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null},{"id":"pmh:oai:e-spacio.uned.es:20.500.14468/23891","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105226.","pdf_url":null,"source":{"id":"https://openalex.org/S7407055166","display_name":"UNED repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.biosystems.2024.105226","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2024.105226","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W643863419","https://openalex.org/W1964465385","https://openalex.org/W2020454825","https://openalex.org/W2028932050","https://openalex.org/W2040746730","https://openalex.org/W2087895317","https://openalex.org/W2104056684","https://openalex.org/W2148449367","https://openalex.org/W2158631600","https://openalex.org/W2483974599","https://openalex.org/W2754230492","https://openalex.org/W2766860427","https://openalex.org/W2773221773","https://openalex.org/W2984829254","https://openalex.org/W3169803552","https://openalex.org/W3184966943","https://openalex.org/W3199378538","https://openalex.org/W4229716052","https://openalex.org/W4292442926","https://openalex.org/W4316126949","https://openalex.org/W4319868497","https://openalex.org/W4324044794","https://openalex.org/W4380884801","https://openalex.org/W6601804127","https://openalex.org/W6675747651","https://openalex.org/W6738102928","https://openalex.org/W6754965036","https://openalex.org/W6769686331","https://openalex.org/W6796892192","https://openalex.org/W6812879547","https://openalex.org/W6849939824"],"related_works":["https://openalex.org/W2314134133","https://openalex.org/W1574317441","https://openalex.org/W2055592795","https://openalex.org/W4232382212","https://openalex.org/W3122195146","https://openalex.org/W2372620761","https://openalex.org/W2355914877","https://openalex.org/W2083262586","https://openalex.org/W2613453305","https://openalex.org/W1731616892"],"abstract_inverted_index":{"Robert":[0],"Rosen":[1],"defines":[2],"organisms":[3],"as":[4,18],"material":[5],"systems":[6],"closed":[7],"to":[8,102,118,147,155,159],"efficient":[9,103,148],"causation,":[10],"and":[11,45,124,139],"proposes":[12],"the":[13,39,50,64,69,81,112,119,125,133,136,144,153],"replicative":[14,120],"(M,":[15,107,121,127],"R)":[16,108,122,128],"system":[17,98,123],"a":[19,26,58,73,91,96,105],"model":[20,28,60,93],"for":[21],"them.":[22],"Recently,":[23],"we":[24,56,131,151],"presented":[25],"cell":[27,43,59,92],"that":[29,83,94,99,116,135],"realizes":[30,100],"Rosen's":[31,47],"formal":[32],"model,":[33],"based":[34],"on":[35,46],"Hofmeyr's":[36],"analysis":[37,158],"of":[38,42,49,75,80,114],"functional":[40],"organization":[41],"biochemistry":[44],"construction":[48],"replication":[51,70],"function.":[52],"In":[53],"this":[54,157],"article":[55],"propose":[57],"that,":[61],"starting":[62],"from":[63],"same":[65],"biochemical":[66],"processes,":[67],"replaces":[68],"function":[71],"with":[72],"set":[74],"semiotic":[76,97,106,126,145],"relations":[77],"between":[78],"some":[79],"elements":[82],"participate":[84],"in":[85,143],"cellular":[86],"processes.":[87],"The":[88],"result":[89],"is":[90],"constitutes":[95],"closure":[101,115,146],"causation:":[104],"system.":[109,129],"We":[110],"compare":[111],"models":[113],"correspond":[117],"Additionally,":[130],"discuss":[132],"role":[134],"genetic":[137],"code":[138],"protein":[140],"synthesis":[141],"play":[142],"causation.":[149],"Finally,":[150],"outline":[152],"method":[154],"extend":[156],"more":[160],"complex":[161],"organisms.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-28T08:17:26.163206","created_date":"2025-10-10T00:00:00"}
