{"id":"https://openalex.org/W3161589253","doi":"https://doi.org/10.1016/j.biosystems.2021.104442","title":"From RNA to DNA: Insights about the transition of informational molecule in the biological systems based on the structural proximity between the polymerases","display_name":"From RNA to DNA: Insights about the transition of informational molecule in the biological systems based on the structural proximity between the polymerases","publication_year":2021,"publication_date":"2021-05-10","ids":{"openalex":"https://openalex.org/W3161589253","doi":"https://doi.org/10.1016/j.biosystems.2021.104442","mag":"3161589253","pmid":"https://pubmed.ncbi.nlm.nih.gov/33984392"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2021.104442","doi":"https://doi.org/10.1016/j.biosystems.2021.104442","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2021.104442","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosystems","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052315969","display_name":"Ariosvaldo Pereira dos Santos","orcid":"https://orcid.org/0000-0001-8797-7620","observed_orcids":["https://orcid.org/0000-0001-8797-7620"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ariosvaldo Pereira dos Santos Junior","raw_affiliation_strings":["Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8797-7620","affiliations":[{"raw_affiliation_string":"Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024102542","display_name":"Marco V. Jos\u00e9","orcid":"https://orcid.org/0000-0001-8497-6681","observed_orcids":["https://orcid.org/0000-0001-8497-6681"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Marco V. Jos\u00e9","raw_affiliation_strings":["Theoretical Biology Group, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, C.P. 04510, Mexico. Electronic address: marcojose@biomedicas.unam.mx","Theoretical Biology Group, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, C.P. 04510, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-8497-6681","affiliations":[{"raw_affiliation_string":"Theoretical Biology Group, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, C.P. 04510, Mexico. Electronic address: marcojose@biomedicas.unam.mx","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Theoretical Biology Group, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, C.P. 04510, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058776961","display_name":"S\u00e1vio Torres de Far\u00edas","orcid":"https://orcid.org/0000-0002-2997-3629","observed_orcids":["https://orcid.org/0000-0002-2997-3629"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]},{"id":"https://openalex.org/I4405283919","display_name":"The NoRCEL Institute","ror":"https://ror.org/02h8bj412","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405283919"]}],"countries":["BR","GB"],"is_corresponding":true,"raw_author_name":"S\u00e1vio Torres de Farias","raw_affiliation_strings":["Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil; Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds, LS7 3RB, UK. Electronic address: stfarias@yahoo.com.br","Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil","Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds, LS7 3RB, UK"],"raw_orcid":"https://orcid.org/0000-0002-2997-3629","affiliations":[{"raw_affiliation_string":"Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil; Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds, LS7 3RB, UK. Electronic address: stfarias@yahoo.com.br","institution_ids":["https://openalex.org/I169045520","https://openalex.org/I4405283919"]},{"raw_affiliation_string":"Departamento de Biologia Molecular, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds, LS7 3RB, UK","institution_ids":["https://openalex.org/I4405283919"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024102542","https://openalex.org/A5058776961"],"corresponding_institution_ids":["https://openalex.org/I169045520","https://openalex.org/I4405269066","https://openalex.org/I4405283919","https://openalex.org/I8961855"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":null,"fwci":1.0982,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75569404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"206","issue":null,"first_page":"104442","last_page":"104442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.746999979019165},{"id":"https://openalex.org/keywords/origin-of-dna","display_name":"origin of DNA","score":0.6570000052452087},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/evolutionary-radiation","display_name":"evolutionary radiation","score":0.45100000500679016},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.7118139266967773},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6510431170463562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468971729278564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4856187403202057},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48526856303215027},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.48065245151519775},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4706380069255829},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3466866612434387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21005091071128845}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2021.104442","doi":"https://doi.org/10.1016/j.biosystems.2021.104442","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2021.104442","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosystems","raw_type":"journal-article"},{"id":"pmid:33984392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33984392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1520835950","https://openalex.org/W1968282235","https://openalex.org/W2010736443","https://openalex.org/W2021333801","https://openalex.org/W2030421748","https://openalex.org/W2067371216","https://openalex.org/W2085720218","https://openalex.org/W2102245393","https://openalex.org/W2129162844","https://openalex.org/W2154124197","https://openalex.org/W2256933318","https://openalex.org/W2299605201","https://openalex.org/W2754416383","https://openalex.org/W2791400386","https://openalex.org/W2988493958","https://openalex.org/W3033908813","https://openalex.org/W3118123444","https://openalex.org/W3126166777","https://openalex.org/W6657804016"],"related_works":["https://openalex.org/W2034409080","https://openalex.org/W2398277866","https://openalex.org/W2074011169","https://openalex.org/W2077167296","https://openalex.org/W1936051282","https://openalex.org/W2031882707","https://openalex.org/W2076445634","https://openalex.org/W2025103069","https://openalex.org/W1972765689","https://openalex.org/W2624814344"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}