{"id":"https://openalex.org/W3014530003","doi":"https://doi.org/10.1016/j.biosystems.2020.104135","title":"Probability of change in life: Amino acid changes in single nucleotide substitutions","display_name":"Probability of change in life: Amino acid changes in single nucleotide substitutions","publication_year":2020,"publication_date":"2020-04-04","ids":{"openalex":"https://openalex.org/W3014530003","doi":"https://doi.org/10.1016/j.biosystems.2020.104135","mag":"3014530003","pmid":"https://pubmed.ncbi.nlm.nih.gov/32259562"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2020.104135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2020.104135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0303264720300393","source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0303264720300393","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045919621","display_name":"Kwok-Fong Chan","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kwok-Fong Chan","raw_affiliation_strings":["Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore"],"affiliations":[{"raw_affiliation_string":"Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036606863","display_name":"Stelios Koukouravas","orcid":"https://orcid.org/0009-0005-0876-435X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stelios Koukouravas","raw_affiliation_strings":["Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore"],"affiliations":[{"raw_affiliation_string":"Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069585075","display_name":"Joshua Yi Yeo","orcid":"https://orcid.org/0000-0002-0253-0238"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Yi Yeo","raw_affiliation_strings":["Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore"],"affiliations":[{"raw_affiliation_string":"Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041763057","display_name":"Darius Wen\u2010Shuo Koh","orcid":"https://orcid.org/0000-0003-1100-2346"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darius Wen-Shuo Koh","raw_affiliation_strings":["Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore"],"affiliations":[{"raw_affiliation_string":"Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038527769","display_name":"Samuel Ken\u2010En Gan","orcid":"https://orcid.org/0000-0001-9936-5090"},"institutions":[{"id":"https://openalex.org/I4210161496","display_name":"A*STAR Graduate Academy","ror":"https://ror.org/059yjzn93","country_code":"SG","type":"education","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210161496"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Samuel Ken-En Gan","raw_affiliation_strings":["Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore; P53 Laboratory, A(\u2217)STAR, Singapore; Experimental Drug Development Centre, A(\u2217)STAR, Singapore. Electronic address: samuelg@bii.a-star.edu.sg","P53 Laboratory, A\u2217STAR, Singapore"],"affiliations":[{"raw_affiliation_string":"Antibody & Product Development Lab, BII, A(\u2217)STAR, 138671, Singapore; P53 Laboratory, A(\u2217)STAR, Singapore; Experimental Drug Development Centre, A(\u2217)STAR, Singapore. Electronic address: samuelg@bii.a-star.edu.sg","institution_ids":[]},{"raw_affiliation_string":"P53 Laboratory, A\u2217STAR, Singapore","institution_ids":["https://openalex.org/I4210161496"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045919621"],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.9177,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.72680077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"193-194","issue":null,"first_page":"104135","last_page":"104135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-code","display_name":"Genetic code","score":0.9215338230133057},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.7947943806648254},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.587949812412262},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5507683157920837},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4687621295452118},{"id":"https://openalex.org/keywords/nucleotide","display_name":"Nucleotide","score":0.4286808669567108},{"id":"https://openalex.org/keywords/stop-codon","display_name":"Stop codon","score":0.4132798910140991},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.374059796333313},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30296313762664795}],"concepts":[{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.9215338230133057},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7947943806648254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.587949812412262},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5507683157920837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4687621295452118},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4286808669567108},{"id":"https://openalex.org/C20580545","wikidata":"https://www.wikidata.org/wiki/Q28354","display_name":"Stop codon","level":3,"score":0.4132798910140991},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.374059796333313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30296313762664795}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2020.104135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2020.104135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0303264720300393","source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosystems","raw_type":"journal-article"},{"id":"pmid:32259562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32259562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.biosystems.2020.104135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2020.104135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0303264720300393","source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosystems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014530003.pdf","grobid_xml":"https://content.openalex.org/works/W3014530003.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W51482956","https://openalex.org/W1963573192","https://openalex.org/W1992486617","https://openalex.org/W1995143868","https://openalex.org/W2007091552","https://openalex.org/W2008365039","https://openalex.org/W2019421676","https://openalex.org/W2030297710","https://openalex.org/W2042316019","https://openalex.org/W2062715887","https://openalex.org/W2068694787","https://openalex.org/W2079750805","https://openalex.org/W2096110335","https://openalex.org/W2105943646","https://openalex.org/W2117692326","https://openalex.org/W2132109794","https://openalex.org/W2242165656","https://openalex.org/W2562869709","https://openalex.org/W2624838086","https://openalex.org/W2767199480","https://openalex.org/W2789825453","https://openalex.org/W2793692203","https://openalex.org/W2887758729","https://openalex.org/W2933546552","https://openalex.org/W2949566896","https://openalex.org/W2972801475","https://openalex.org/W3187992181","https://openalex.org/W4210970197","https://openalex.org/W4211225058","https://openalex.org/W4229626805","https://openalex.org/W4255633404"],"related_works":["https://openalex.org/W97567589","https://openalex.org/W2080601739","https://openalex.org/W3020887404","https://openalex.org/W2102971391","https://openalex.org/W2064088083","https://openalex.org/W1982081746","https://openalex.org/W2360347211","https://openalex.org/W168348071","https://openalex.org/W2462560104","https://openalex.org/W2949181752"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}