{"id":"https://openalex.org/W7160608103","doi":"https://doi.org/10.1016/j.asoc.2026.115422","title":"Parallel ACO-VNS for the solution of binary combinatorial optimization problems in computational systems biology","display_name":"Parallel ACO-VNS for the solution of binary combinatorial optimization problems in computational systems biology","publication_year":2026,"publication_date":"2026-05-08","ids":{"openalex":"https://openalex.org/W7160608103","doi":"https://doi.org/10.1016/j.asoc.2026.115422"},"language":"en","primary_location":{"id":"doi:10.1016/j.asoc.2026.115422","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.asoc.2026.115422","pdf_url":null,"source":{"id":"https://openalex.org/S140556538","display_name":"Applied Soft Computing","issn_l":"1568-4946","issn":["1568-4946","1872-9681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Soft Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.asoc.2026.115422","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028852653","display_name":"Roberto Prado\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0003-2651-8804"},"institutions":[{"id":"https://openalex.org/I11019714","display_name":"Universidade da Coru\u00f1a","ror":"https://ror.org/01qckj285","country_code":"ES","type":"education","lineage":["https://openalex.org/I11019714"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Prado-Rodr\u00edguez","raw_affiliation_strings":["CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2651-8804","affiliations":[{"raw_affiliation_string":"CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I11019714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135719346","display_name":"Patricia Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-0378-9222"},"institutions":[{"id":"https://openalex.org/I11019714","display_name":"Universidade da Coru\u00f1a","ror":"https://ror.org/01qckj285","country_code":"ES","type":"education","lineage":["https://openalex.org/I11019714"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Patricia Gonz\u00e1lez","raw_affiliation_strings":["CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0378-9222","affiliations":[{"raw_affiliation_string":"CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I11019714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135678242","display_name":"Julio R. Banga","orcid":"https://orcid.org/0000-0002-4245-0320"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210098595","display_name":"Misi\u00f3n Biol\u00f3gica de Galicia","ror":"https://ror.org/00tpn9z48","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210098595"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio R. Banga","raw_affiliation_strings":["Computational Biology Lab, MBG-CSIC, Spanish National Research Council, Pontevedra, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4245-0320","affiliations":[{"raw_affiliation_string":"Computational Biology Lab, MBG-CSIC, Spanish National Research Council, Pontevedra, Spain","institution_ids":["https://openalex.org/I4210098595","https://openalex.org/I134820265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070686724","display_name":"Ram\u00f3n Doallo","orcid":"https://orcid.org/0000-0002-6011-3387"},"institutions":[{"id":"https://openalex.org/I11019714","display_name":"Universidade da Coru\u00f1a","ror":"https://ror.org/01qckj285","country_code":"ES","type":"education","lineage":["https://openalex.org/I11019714"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Doallo","raw_affiliation_strings":["CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITIC, Computer Architecture Group, University of A Coru\u00f1a, A Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I11019714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5135719346"],"corresponding_institution_ids":["https://openalex.org/I11019714"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":{"value":3350,"currency":"USD","value_usd":3350},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85692718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":null,"first_page":"115422","last_page":"115422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.1996999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.1996999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.6952999830245972},{"id":"https://openalex.org/keywords/combinatorial-optimization","display_name":"Combinatorial optimization","score":0.6327999830245972},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.5902000069618225},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.487199991941452},{"id":"https://openalex.org/keywords/optimization-problem","display_name":"Optimization problem","score":0.4250999987125397},{"id":"https://openalex.org/keywords/computational-complexity-theory","display_name":"Computational complexity theory","score":0.41130000352859497},{"id":"https://openalex.org/keywords/computational-problem","display_name":"Computational problem","score":0.35899999737739563},{"id":"https://openalex.org/keywords/membrane-computing","display_name":"Membrane computing","score":0.3301999866962433}],"concepts":[{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.6952999830245972},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6434999704360962},{"id":"https://openalex.org/C52692508","wikidata":"https://www.wikidata.org/wiki/Q1333872","display_name":"Combinatorial optimization","level":2,"score":0.6327999830245972},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.5902000069618225},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.487199991941452},{"id":"https://openalex.org/C137836250","wikidata":"https://www.wikidata.org/wiki/Q984063","display_name":"Optimization problem","level":2,"score":0.4250999987125397},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4246000051498413},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.42010000348091125},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3776000142097473},{"id":"https://openalex.org/C19754495","wikidata":"https://www.wikidata.org/wiki/Q3435924","display_name":"Computational problem","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C96011364","wikidata":"https://www.wikidata.org/wiki/Q6815122","display_name":"Membrane computing","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29919999837875366},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C2988809283","wikidata":"https://www.wikidata.org/wiki/Q1514868","display_name":"Combinatorial algorithms","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C109718341","wikidata":"https://www.wikidata.org/wiki/Q1385229","display_name":"Metaheuristic","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C115908005","wikidata":"https://www.wikidata.org/wiki/Q2668364","display_name":"Combinatorial explosion","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2779521423","wikidata":"https://www.wikidata.org/wiki/Q3855646","display_name":"Combinatorial method","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.asoc.2026.115422","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.asoc.2026.115422","pdf_url":null,"source":{"id":"https://openalex.org/S140556538","display_name":"Applied Soft Computing","issn_l":"1568-4946","issn":["1568-4946","1872-9681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Soft Computing","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.asoc.2026.115422","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.asoc.2026.115422","pdf_url":null,"source":{"id":"https://openalex.org/S140556538","display_name":"Applied Soft Computing","issn_l":"1568-4946","issn":["1568-4946","1872-9681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Soft Computing","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320325108","display_name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria, Xunta de Galicia","ror":"https://ror.org/03gq5rs15"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1801849579","https://openalex.org/W1978074159","https://openalex.org/W1982693868","https://openalex.org/W1984779822","https://openalex.org/W2002556869","https://openalex.org/W2005666336","https://openalex.org/W2013205100","https://openalex.org/W2014538668","https://openalex.org/W2015612612","https://openalex.org/W2033050569","https://openalex.org/W2034531826","https://openalex.org/W2038456806","https://openalex.org/W2041282815","https://openalex.org/W2063769328","https://openalex.org/W2070575286","https://openalex.org/W2071828883","https://openalex.org/W2095595785","https://openalex.org/W2096166399","https://openalex.org/W2097377813","https://openalex.org/W2108933868","https://openalex.org/W2125789330","https://openalex.org/W2127020923","https://openalex.org/W2129935828","https://openalex.org/W2143784594","https://openalex.org/W2150834164","https://openalex.org/W2154929945","https://openalex.org/W2159427933","https://openalex.org/W2161258924","https://openalex.org/W2164987379","https://openalex.org/W2165603655","https://openalex.org/W2211456108","https://openalex.org/W2477670937","https://openalex.org/W2516530272","https://openalex.org/W2571863445","https://openalex.org/W2591844254","https://openalex.org/W2761296247","https://openalex.org/W2766326994","https://openalex.org/W2936686072","https://openalex.org/W2937748796","https://openalex.org/W2944836728","https://openalex.org/W2972093761","https://openalex.org/W2986455832","https://openalex.org/W3008773008","https://openalex.org/W3014817892","https://openalex.org/W3035157585","https://openalex.org/W3046010471","https://openalex.org/W3187330577","https://openalex.org/W3212823353","https://openalex.org/W4286255657","https://openalex.org/W4288716106","https://openalex.org/W4292083457","https://openalex.org/W4303712284","https://openalex.org/W4391621146","https://openalex.org/W4401691533","https://openalex.org/W4406248080","https://openalex.org/W4409858582"],"related_works":[],"abstract_inverted_index":{"In":[0],"this":[1],"work,":[2],"a":[3,29,33,69,142],"parallel":[4,144],"hybrid":[5,89],"framework":[6,105],"that":[7,37,86],"combines":[8],"Ant":[9],"Colony":[10],"Optimization":[11],"(ACO)":[12],"with":[13,32,131],"Variable":[14,132],"Neighborhood":[15,133],"Search":[16,134],"(VNS)":[17],"to":[18,49,151],"enhance":[19],"both":[20],"exploration":[21],"and":[22,99],"intensification":[23],"is":[24,66],"proposed.":[25],"The":[26,63,94],"method":[27],"integrates":[28],"multicolony":[30,143],"architecture":[31],"self-adaptive":[34],"cooperation":[35,140],"mechanism":[36],"dynamically":[38],"regulates":[39],"information":[40],"exchange":[41],"among":[42],"colonies":[43],"during":[44],"runtime.":[45],"This":[46],"design":[47],"aims":[48],"overcome":[50],"the":[51,87,97,103,122],"limitations":[52],"of":[53,71,102,124,153],"standalone":[54,92],"ACO":[55,115,129],"while":[56],"maintaining":[57],"scalability":[58],"on":[59,68,141],"high-performance":[60],"computing":[61],"platforms.":[62],"proposed":[64,104],"approach":[65],"evaluated":[67],"set":[70],"challenging":[72],"large-scale":[73],"binary":[74,108,118],"optimization":[75,110,119],"benchmarks":[76],"derived":[77],"from":[78],"cell":[79,154],"signaling":[80],"network":[81],"modeling.":[82],"Experimental":[83],"results":[84,95],"show":[85],"ACO\u2013VNS":[88],"consistently":[90],"outperforms":[91],"ACO.":[93],"demonstrate":[96],"effectiveness":[98],"general":[100],"applicability":[101],"for":[106,117],"complex":[107],"combinatorial":[109],"problems.":[111],"\u2022":[112,127,138,146],"A":[113],"new":[114],"proposal":[116],"problems":[120,149],"in":[121],"field":[123],"Biology":[125],"Systems.":[126],"Hybrid":[128],"metaheuristic":[130],"as":[135],"local":[136],"search.":[137],"Self-adaptive":[139],"strategy.":[145],"Tested":[147],"using":[148],"related":[150],"modelling":[152],"signalling":[155],"networks.":[156]},"counts_by_year":[],"updated_date":"2026-05-15T06:05:50.897203","created_date":"2026-05-09T00:00:00"}