{"id":"https://openalex.org/W4415420355","doi":"https://doi.org/10.1007/s44443-025-00003-8","title":"MoX: an explainable hybrid deep-learning model for integrating multi-omics data to predict event-free survival in neuroblastoma prognosis","display_name":"MoX: an explainable hybrid deep-learning model for integrating multi-omics data to predict event-free survival in neuroblastoma prognosis","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415420355","doi":"https://doi.org/10.1007/s44443-025-00003-8"},"language":"en","primary_location":{"id":"doi:10.1007/s44443-025-00003-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44443-025-00003-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44443-025-00003-8.pdf","source":{"id":"https://openalex.org/S2764955546","display_name":"Journal of King Saud University - Computer and Information Sciences","issn_l":"1319-1578","issn":["1319-1578","2213-1248"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of King Saud University Computer and Information Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s44443-025-00003-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"CKishor Kumar Reddy","orcid":null},"institutions":[{"id":"https://openalex.org/I25051037","display_name":"Stanley Medical College","ror":"https://ror.org/0567p6j84","country_code":"IN","type":"education","lineage":["https://openalex.org/I25051037"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"CKishor Kumar Reddy","raw_affiliation_strings":["Department of Computer Science and Engineering, Stanley College of Engineering and Technology for Women, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Stanley College of Engineering and Technology for Women, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I25051037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093509689","display_name":"Vijaya Sindhoori Kaza","orcid":"https://orcid.org/0000-0002-1364-8530"},"institutions":[{"id":"https://openalex.org/I4210117576","display_name":"Hewlett-Packard (India)","ror":"https://ror.org/02ffkja82","country_code":"IN","type":"company","lineage":["https://openalex.org/I1324840837","https://openalex.org/I4210117576"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijaya Sindhoori Kaza","raw_affiliation_strings":["Hewlett Packard Enterprise, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hewlett Packard Enterprise, Bangalore, India","institution_ids":["https://openalex.org/I4210117576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099584822","display_name":"Advaitha Daduvy","orcid":"https://orcid.org/0009-0006-7011-5577"},"institutions":[{"id":"https://openalex.org/I4210117576","display_name":"Hewlett-Packard (India)","ror":"https://ror.org/02ffkja82","country_code":"IN","type":"company","lineage":["https://openalex.org/I1324840837","https://openalex.org/I4210117576"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Advaitha Daduvy","raw_affiliation_strings":["Hewlett Packard Enterprise, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hewlett Packard Enterprise, Bangalore, India","institution_ids":["https://openalex.org/I4210117576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071211251","display_name":"Mohammed Shuaib","orcid":"https://orcid.org/0000-0001-6657-2587"},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammed Shuaib","raw_affiliation_strings":["Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005154368","display_name":"Faisal Alshanketi","orcid":"https://orcid.org/0000-0001-5982-5937"},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Faisal Alshanketi","raw_affiliation_strings":["Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-5982-5937","affiliations":[{"raw_affiliation_string":"Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074848011","display_name":"Shadab Alam","orcid":"https://orcid.org/0000-0003-0504-4515"},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Shadab Alam","raw_affiliation_strings":["Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, College of Engineering and Computer Science, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005154368"],"corresponding_institution_ids":["https://openalex.org/I91450128"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38672754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9781000018119812,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.781499981880188},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"Neuroblastoma","score":0.5479000210762024},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5468999743461609},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5457000136375427},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.4293999969959259},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4065000116825104},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.39890000224113464},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.37540000677108765},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.3443000018596649}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.781499981880188},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5479000210762024},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5468999743461609},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5457000136375427},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49559998512268066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4447999894618988},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4374000132083893},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.39890000224113464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3912000060081482},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35519999265670776},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35120001435279846},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3443000018596649},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.30649998784065247},{"id":"https://openalex.org/C16910744","wikidata":"https://www.wikidata.org/wiki/Q7705759","display_name":"Test data","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C110332635","wikidata":"https://www.wikidata.org/wiki/Q629498","display_name":"Genetic programming","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.25060001015663147},{"id":"https://openalex.org/C2984324147","wikidata":"https://www.wikidata.org/wiki/Q3080021","display_name":"Gene selection","level":5,"score":0.25}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s44443-025-00003-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44443-025-00003-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44443-025-00003-8.pdf","source":{"id":"https://openalex.org/S2764955546","display_name":"Journal of King Saud University - Computer and Information Sciences","issn_l":"1319-1578","issn":["1319-1578","2213-1248"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of King Saud University Computer and Information Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4f3c1db483de41fcb0bd3b84bc73f5ac","is_oa":true,"landing_page_url":"https://doaj.org/article/4f3c1db483de41fcb0bd3b84bc73f5ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of King Saud University: Computer and Information Sciences, Vol 37, Iss 9, Pp 1-34 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s44443-025-00003-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44443-025-00003-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44443-025-00003-8.pdf","source":{"id":"https://openalex.org/S2764955546","display_name":"Journal of King Saud University - Computer and Information Sciences","issn_l":"1319-1578","issn":["1319-1578","2213-1248"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of King Saud University Computer and Information Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311223","display_name":"Jazan University","ror":"https://ror.org/02bjnq803"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415420355.pdf","grobid_xml":"https://content.openalex.org/works/W4415420355.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W145418528","https://openalex.org/W1529762244","https://openalex.org/W1980134441","https://openalex.org/W2036502860","https://openalex.org/W2044640853","https://openalex.org/W2074070461","https://openalex.org/W2101120698","https://openalex.org/W2104593681","https://openalex.org/W2105366850","https://openalex.org/W2112612051","https://openalex.org/W2114031931","https://openalex.org/W2117060022","https://openalex.org/W2118071133","https://openalex.org/W2131776400","https://openalex.org/W2132546867","https://openalex.org/W2139558183","https://openalex.org/W2140360759","https://openalex.org/W2171873561","https://openalex.org/W2213548494","https://openalex.org/W2219761119","https://openalex.org/W2561771531","https://openalex.org/W2564018391","https://openalex.org/W2761668583","https://openalex.org/W2794248491","https://openalex.org/W2801926025","https://openalex.org/W2805577857","https://openalex.org/W2807594517","https://openalex.org/W2892933709","https://openalex.org/W2969802495","https://openalex.org/W2972472681","https://openalex.org/W2990360409","https://openalex.org/W3013462789","https://openalex.org/W3016966623","https://openalex.org/W4282049424","https://openalex.org/W4387002937","https://openalex.org/W4396950203"],"related_works":[],"abstract_inverted_index":{"Neuroblastoma,":[0],"a":[1,17,47,110,127,143,218,237,245,256],"challenging":[2],"pediatric":[3],"cancer,":[4],"requires":[5],"effective":[6],"prediction":[7],"models":[8],"to":[9,22,95,155],"improve":[10],"patient":[11],"outcomes.":[12],"This":[13,234],"paper":[14,235],"introduces":[15],"MoX,":[16],"hybrid":[18],"deep-learning":[19],"model":[20,39,125,246],"designed":[21],"predict":[23],"event-free":[24,158],"survival":[25,161],"(EFS)":[26],"in":[27,183,230,240,268],"neuroblastoma":[28,241],"patients":[29],"by":[30,98,243],"integrating":[31,61],"both":[32],"clinical":[33,57,78],"and":[34,56,77,88,119,142,159,177,196,201,204,214,226,264],"genetic":[35],"data.":[36],"The":[37,80,124,163],"MoX":[38,105,216],"combines":[40],"feature":[41],"selection":[42],"via":[43],"Random":[44],"Forest":[45],"with":[46,109,147],"dual-branch":[48],"deep":[49],"learning":[50],"architecture":[51],"that":[52,167,247],"processes":[53],"gene":[54,74],"expression":[55,75],"features":[58],"separately":[59],"before":[60],"them":[62],"for":[63,136,221],"final":[64],"predictions.":[65],"It":[66],"was":[67],"evaluated":[68,84],"using":[69],"the":[70,100,131,137,180,190],"GSE85047":[71],"dataset,":[72],"encompassing":[73],"profiles":[76],"attributes.":[79],"model\u2019s":[81],"performance":[82,108,213,252],"is":[83,93],"through":[85],"K-Fold":[86],"Cross-Validation,":[87],"SHAP":[89,164],"(SHapley":[90],"Additive":[91],"exPlanations)":[92],"utilized":[94],"ensure":[96],"interpretability":[97],"elucidating":[99],"contribution":[101],"of":[102,113,117,122,134,150,208,259],"individual":[103],"features.":[104],"demonstrated":[106],"exceptional":[107],"training":[111,195],"accuracy":[112,116,121],"96.79%,":[114],"validation":[115,197],"98.15%,":[118],"test":[120,138],"98.89%.":[123],"achieved":[126],"high":[128,205,257],"Area":[129],"Under":[130],"Curve":[132],"(AUC)":[133],"0.992":[135],"data":[139,232,270],"ROC":[140],"curve":[141,146],"Precision-Recall":[144],"(PR)":[145],"an":[148],"AUC":[149],"0.989,":[151],"highlighting":[152],"its":[153,211],"ability":[154],"distinguish":[156],"between":[157],"non-event-free":[160],"effectively.":[162],"analysis":[165],"revealed":[166],"genes":[168],"such":[169],"as":[170],"CD9":[171],",":[172,174,176],"GABRB3":[173],"FRAS1":[175],"IGF2BP1":[178],"were":[179],"most":[181],"influential":[182],"predicting":[184],"outcomes,":[185],"offering":[186],"valuable":[187],"insights":[188],"into":[189],"model's":[191],"interpretability.":[192],"MoX's":[193],"low":[194],"loss":[198],"values":[199],"(0.082":[200],"0.099,":[202],"respectively)":[203],"F1":[206],"score":[207],"0.989":[209],"underscore":[210],"robust":[212],"reliability.":[215],"provides":[217,255],"powerful":[219],"tool":[220],"enhancing":[222],"personalized":[223],"treatment":[224],"strategies":[225],"guiding":[227,265],"future":[228,266],"research":[229,267],"multi-omic":[231,269],"integration.":[233,271],"marks":[236],"significant":[238],"advancement":[239],"prognosis":[242],"presenting":[244],"not":[248],"only":[249],"enhances":[250],"predictive":[251],"but":[253],"also":[254],"level":[258],"interpretability,":[260],"supporting":[261],"precision":[262],"oncology":[263]},"counts_by_year":[],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-10-24T00:00:00"}