{"id":"https://openalex.org/W4376106126","doi":"https://doi.org/10.1007/s44163-023-00064-6","title":"Investigation of metabolic pathways from gut microbiome analyses regarding type 2 diabetes mellitus using artificial neural networks","display_name":"Investigation of metabolic pathways from gut microbiome analyses regarding type 2 diabetes mellitus using artificial neural networks","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4376106126","doi":"https://doi.org/10.1007/s44163-023-00064-6"},"language":"en","primary_location":{"id":"doi:10.1007/s44163-023-00064-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44163-023-00064-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44163-023-00064-6.pdf","source":{"id":"https://openalex.org/S4210220416","display_name":"Discover Artificial Intelligence","issn_l":"2731-0809","issn":["2731-0809"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s44163-023-00064-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011591195","display_name":"Julienne Siptroth","orcid":"https://orcid.org/0000-0003-4888-5234"},"institutions":[{"id":"https://openalex.org/I38517508","display_name":"Technical University of Applied Sciences Wildau","ror":"https://ror.org/00k62pe27","country_code":"DE","type":"education","lineage":["https://openalex.org/I38517508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Julienne Siptroth","raw_affiliation_strings":["High Performance Computing in Life Sciences, Technical University of Applied Sciences Wildau, 15745, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computing in Life Sciences, Technical University of Applied Sciences Wildau, 15745, Wildau, Germany","institution_ids":["https://openalex.org/I38517508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081143652","display_name":"Olga Moskalenko","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Moskalenko","raw_affiliation_strings":["BIOMES NGS GmbH, Schwartzkopfstra\u00dfe 1, 15745, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOMES NGS GmbH, Schwartzkopfstra\u00dfe 1, 15745, Wildau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031617558","display_name":"Carsten Krumbiegel","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten Krumbiegel","raw_affiliation_strings":["BIOMES NGS GmbH, Schwartzkopfstra\u00dfe 1, 15745, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOMES NGS GmbH, Schwartzkopfstra\u00dfe 1, 15745, Wildau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101628744","display_name":"J\u00f6rg Ackermann","orcid":"https://orcid.org/0000-0002-9942-0958"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Ackermann","raw_affiliation_strings":["Department of Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt, 60325, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt, 60325, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015346451","display_name":"Ina Koch","orcid":"https://orcid.org/0000-0002-3621-003X"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ina Koch","raw_affiliation_strings":["Department of Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt, 60325, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt, 60325, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044894045","display_name":"Heike Pospisil","orcid":"https://orcid.org/0000-0002-2561-9665"},"institutions":[{"id":"https://openalex.org/I38517508","display_name":"Technical University of Applied Sciences Wildau","ror":"https://ror.org/00k62pe27","country_code":"DE","type":"education","lineage":["https://openalex.org/I38517508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heike Pospisil","raw_affiliation_strings":["High Performance Computing in Life Sciences, Technical University of Applied Sciences Wildau, 15745, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computing in Life Sciences, Technical University of Applied Sciences Wildau, 15745, Wildau, Germany","institution_ids":["https://openalex.org/I38517508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011591195"],"corresponding_institution_ids":["https://openalex.org/I38517508"],"apc_list":{"value":1340,"currency":"USD","value_usd":1340},"apc_paid":{"value":975,"currency":"EUR","value_usd":1051},"fwci":0.6492,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63901996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.6620370149612427},{"id":"https://openalex.org/keywords/type-2-diabetes-mellitus","display_name":"Type 2 Diabetes Mellitus","score":0.6552271842956543},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6242449879646301},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5886896252632141},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.5708166360855103},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5524274706840515},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.48988550901412964},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.46944141387939453},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42029237747192383},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.41409850120544434},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4060990512371063},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3851397633552551},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34711188077926636},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.26181721687316895},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.16374975442886353},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15496650338172913},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.08771908283233643}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6620370149612427},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.6552271842956543},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6242449879646301},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5886896252632141},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5708166360855103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5524274706840515},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.48988550901412964},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.46944141387939453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42029237747192383},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.41409850120544434},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4060990512371063},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3851397633552551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34711188077926636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26181721687316895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16374975442886353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15496650338172913},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08771908283233643},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s44163-023-00064-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44163-023-00064-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44163-023-00064-6.pdf","source":{"id":"https://openalex.org/S4210220416","display_name":"Discover Artificial Intelligence","issn_l":"2731-0809","issn":["2731-0809"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Artificial Intelligence","raw_type":"journal-article"},{"id":"pmh:oai:kobv.de-opus4-th-wildau:1749","is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-th-wildau/frontdoor/index/index/docId/1749","pdf_url":"https://opus4.kobv.de/opus4-th-wildau/files/1749/s44163-023-00064-6.pdf","source":{"id":"https://openalex.org/S4306400195","display_name":"TH Wildau (Technical University of Applied Sciences Wildau)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I38517508","host_organization_name":"Technical University of Applied Sciences Wildau","host_organization_lineage":["https://openalex.org/I38517508"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Artificial Intelligence, 3, 1, Article-Nr. 19","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f544d0370d874f97a97b98d4741234f7","is_oa":true,"landing_page_url":"https://doaj.org/article/f544d0370d874f97a97b98d4741234f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Artificial Intelligence, Vol 3, Iss 1, Pp 1-9 (2023)","raw_type":"article"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:88154","is_oa":true,"landing_page_url":"http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/88154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s44163-023-00064-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44163-023-00064-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44163-023-00064-6.pdf","source":{"id":"https://openalex.org/S4210220416","display_name":"Discover Artificial Intelligence","issn_l":"2731-0809","issn":["2731-0809"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Artificial Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G6349899787","display_name":null,"funder_award_id":"13FH209PX8","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376106126.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1983380748","https://openalex.org/W1994616650","https://openalex.org/W2002681301","https://openalex.org/W2009797711","https://openalex.org/W2020398205","https://openalex.org/W2034285706","https://openalex.org/W2055043387","https://openalex.org/W2116846792","https://openalex.org/W2128601422","https://openalex.org/W2132548846","https://openalex.org/W2146502635","https://openalex.org/W2156125289","https://openalex.org/W2170747616","https://openalex.org/W2284443530","https://openalex.org/W2342249984","https://openalex.org/W2747883519","https://openalex.org/W2755653983","https://openalex.org/W2773791657","https://openalex.org/W2799785839","https://openalex.org/W2800371601","https://openalex.org/W2889278708","https://openalex.org/W3008003211","https://openalex.org/W3030441098","https://openalex.org/W3035965352","https://openalex.org/W3099878876","https://openalex.org/W4220749289","https://openalex.org/W4320489621","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2604155846","https://openalex.org/W3121185202","https://openalex.org/W4390658901","https://openalex.org/W2900546243","https://openalex.org/W3035180550","https://openalex.org/W2790850565","https://openalex.org/W4388834263","https://openalex.org/W1983943311","https://openalex.org/W4206185765","https://openalex.org/W3088497233"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Type":[2],"2":[3,83,122,177,233,252,284],"diabetes":[4,84,123,178,230,249,285],"mellitus":[5,85,124,179,231,250,286],"is":[6,125,185,241],"a":[7,25,29,55,128,133,140,171,181,197,205,223,273,278],"prevalent":[8],"disease":[9,234],"that":[10,170,203],"contributes":[11],"to":[12,32,105,195,199,276,288],"the":[13,33,39,44,75,108,114,153,201,209,219,227,265,290,298],"development":[14],"of":[15,48,77,81,95,120,175,229,264,280],"various":[16,49],"health":[17],"issues,":[18],"including":[19],"kidney":[20],"failure":[21],"and":[22,46,180,226,255,282,287],"strokes.":[23],"As":[24],"result,":[26],"it":[27],"poses":[28],"significant":[30],"challenge":[31],"worldwide":[34],"healthcare":[35],"system.":[36],"Research":[37],"into":[38],"gut":[40,266],"microbiome":[41,78,245],"has":[42],"enabled":[43,126],"identification":[45],"description":[47],"diseases,":[50],"with":[51,74,187],"bacterial":[52,163],"pathways":[53,62,110,202],"playing":[54],"critical":[56,291],"role":[57],"in":[58],"this":[59,214,262],"context.":[60],"These":[61],"link":[63],"individual":[64],"bacteria":[65,294],"based":[66],"on":[67,152,160,208],"their":[68],"biological":[69],"functions.":[70],"This":[71],"study":[72,148,263],"deals":[73],"classification":[76,119,154,174,279],"pathway":[79,225,246,295],"profiles":[80,89,247,296],"type":[82,121,176,232,251,283],"patients.":[86],"Methods":[87],"Pathway":[88],"were":[90,102,111],"determined":[91],"by":[92,113,127,243],"next-generation":[93],"sequencing":[94],"16S":[96],"rDNA":[97],"from":[98,248],"stool":[99],"samples,":[100],"which":[101],"subsequently":[103],"assigned":[104,112],"bacteria.":[106],"Then,":[107],"involved":[109],"identified":[115],"gene":[116],"families.":[117],"The":[118,147,239],"constructed":[129],"neural":[130,156,172,274],"network.":[131],"Furthermore,":[132],"feature":[134],"importance":[135],"analysis":[136],"was":[137,193],"performed":[138],"via":[139],"game":[141],"theoretic":[142],"approach":[143,271],"(SHapley":[144],"Additive":[145],"exPlanations).":[146],"not":[149],"only":[150],"focuses":[151],"using":[155,272],"networks,":[157],"but":[158],"also":[159,236],"identifying":[161],"crucial":[162],"pathways.":[164],"Results":[165],"It":[166,192],"could":[167],"be":[168,237],"shown":[169],"network":[173,275],"healthy":[182,256,281],"comparison":[183,257],"group":[184],"possible":[186,194],"an":[188,270],"excellent":[189],"prediction":[190,211],"accuracy.":[191,212],"create":[196],"ranking":[198],"identify":[200,289],"have":[204],"high":[206],"impact":[207],"model":[210],"In":[213],"way,":[215],"new":[216],"associations":[217],"between":[218],"alteration":[220],"of,":[221],"e.g.":[222],"biosynthetic":[224],"presence":[228],"can":[235],"discovered.":[238],"basis":[240],"formed":[242],"946":[244],"patients":[253],"(272)":[254],"persons":[258],"(674).":[259],"Conclusion":[260],"With":[261],"microbiome,":[267],"we":[268],"present":[269],"obtain":[277],"features.":[292],"Intestinal":[293],"form":[297],"basis.":[299]},"counts_by_year":[{"year":2024,"cited_by_count":7}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}