{"id":"https://openalex.org/W4317831142","doi":"https://doi.org/10.1007/s41109-022-00527-2","title":"An efficient weighted network centrality approach for exploring mechanisms of action of the Ruellia herbal formula for treating rheumatoid arthritis","display_name":"An efficient weighted network centrality approach for exploring mechanisms of action of the Ruellia herbal formula for treating rheumatoid arthritis","publication_year":2023,"publication_date":"2023-01-24","ids":{"openalex":"https://openalex.org/W4317831142","doi":"https://doi.org/10.1007/s41109-022-00527-2"},"language":"en","primary_location":{"id":"doi:10.1007/s41109-022-00527-2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s41109-022-00527-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s41109-022-00527-2.pdf","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s41109-022-00527-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027168830","display_name":"Peter Juma Ochieng","orcid":"https://orcid.org/0000-0001-6497-6481"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]},{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Peter Juma Ochieng","raw_affiliation_strings":["B\u00e1nki Faculty, Obuda University, B\u00e9csi str, Budapest, 1034, Hungary","Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary"],"affiliations":[{"raw_affiliation_string":"B\u00e1nki Faculty, Obuda University, B\u00e9csi str, Budapest, 1034, Hungary","institution_ids":["https://openalex.org/I103356709"]},{"raw_affiliation_string":"Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985431","display_name":"Abrar Hussain","orcid":"https://orcid.org/0000-0002-0511-5777"},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Abrar Hussain","raw_affiliation_strings":["Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary"],"affiliations":[{"raw_affiliation_string":"Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010204878","display_name":"J\u00f3zsef Dombi","orcid":"https://orcid.org/0000-0003-3944-6096"},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00f3zsef Dombi","raw_affiliation_strings":["Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary"],"affiliations":[{"raw_affiliation_string":"Institute of Informatics, University of Szeged, \u00c1rp\u00e1d t\u00e9r, Szeged, 6720, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036966627","display_name":"Mikl\u00f3s Kr\u00e9sz","orcid":"https://orcid.org/0000-0002-7547-1128"},"institutions":[{"id":"https://openalex.org/I118905719","display_name":"University of Primorska","ror":"https://ror.org/05xefg082","country_code":"SI","type":"education","lineage":["https://openalex.org/I118905719"]},{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I4392738086","display_name":"InnoRenew CoE","ror":"https://ror.org/0538nf417","country_code":"SI","type":"nonprofit","lineage":["https://openalex.org/I4392738086"]}],"countries":["HU","SI"],"is_corresponding":false,"raw_author_name":"Mikl\u00f3s Kr\u00e9sz","raw_affiliation_strings":["Andrej Maru\u0161i\u010d Institute, University of Primorska, Muzejski trg 2, 6000, Koper, Slovenia","Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6, Szeged, 6725, Hungary","InnoRenew CoE, Livade 6, 6310, Izola, Slovenia"],"affiliations":[{"raw_affiliation_string":"Andrej Maru\u0161i\u010d Institute, University of Primorska, Muzejski trg 2, 6000, Koper, Slovenia","institution_ids":["https://openalex.org/I118905719"]},{"raw_affiliation_string":"Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6, Szeged, 6725, Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"InnoRenew CoE, Livade 6, 6310, Izola, Slovenia","institution_ids":["https://openalex.org/I4392738086"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027168830"],"corresponding_institution_ids":["https://openalex.org/I103356709","https://openalex.org/I227486990"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":0.2003,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49462902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9557999968528748,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.9184125661849976},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.611468493938446},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"Rheumatoid arthritis","score":0.5819461345672607},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.509491503238678},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.4334696829319},{"id":"https://openalex.org/keywords/network-theory","display_name":"Network theory","score":0.41403326392173767},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3767290711402893},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3423471450805664},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3254181742668152},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25460147857666016},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1662900149822235},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13203290104866028},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11847499012947083},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.09481176733970642}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.9184125661849976},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.611468493938446},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5819461345672607},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.509491503238678},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.4334696829319},{"id":"https://openalex.org/C11804174","wikidata":"https://www.wikidata.org/wiki/Q1192971","display_name":"Network theory","level":2,"score":0.41403326392173767},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3767290711402893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3423471450805664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3254181742668152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25460147857666016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1662900149822235},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13203290104866028},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11847499012947083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09481176733970642},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s41109-022-00527-2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s41109-022-00527-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s41109-022-00527-2.pdf","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},{"id":"pmh:oai:publicatio.bibl.u-szeged.hu:26340","is_oa":true,"landing_page_url":null,"pdf_url":"http://publicatio.bibl.u-szeged.hu/26340/1/2023_Anefficientweightednetwork_Juma_ANS.pdf","source":{"id":"https://openalex.org/S4306400436","display_name":"SZTE Publicatio Repozit\u00f3rium (University of Szeged)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I227486990","host_organization_name":"University of Szeged","host_organization_lineage":["https://openalex.org/I227486990"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Foly\u00f3iratcikk"},{"id":"pmh:oai:zenodo.org:8054669","is_oa":true,"landing_page_url":"https://zenodo.org/record/8054669","pdf_url":"https://zenodo.org/record/8054669","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Springer open","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4f28748d4b7247228078f66eed755c76","is_oa":true,"landing_page_url":"https://doaj.org/article/4f28748d4b7247228078f66eed755c76","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Network Science, Vol 8, Iss 1, Pp 1-29 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s41109-022-00527-2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s41109-022-00527-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s41109-022-00527-2.pdf","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3241820797","display_name":null,"funder_award_id":"RRF-2.3.1-21-2022-00004","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3501631465","display_name":null,"funder_award_id":"39574","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3875748329","display_name":null,"funder_award_id":"European Regional Development Fund","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5460322175","display_name":null,"funder_award_id":"739574","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G6679577976","display_name":null,"funder_award_id":"MILAB","funder_id":"https://openalex.org/F4320336675","funder_display_name":"National Research, Development and Innovation Office"},{"id":"https://openalex.org/G785787759","display_name":null,"funder_award_id":"TKP2021-NVA","funder_id":"https://openalex.org/F4320336675","funder_display_name":"National Research, Development and Innovation Office"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8090288322","display_name":null,"funder_award_id":"TKP2021","funder_id":"https://openalex.org/F4320336675","funder_display_name":"National Research, Development and Innovation Office"},{"id":"https://openalex.org/G8112475816","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8170149473","display_name":null,"funder_award_id":"739574","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8251372944","display_name":null,"funder_award_id":"TKP2021-NVA-09","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8538941428","display_name":null,"funder_award_id":"Regional Development Fund","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G920693169","display_name":null,"funder_award_id":"N2-0171","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"},{"id":"https://openalex.org/F4320329149","display_name":"Szegedi Tudom\u00e1nyegyetem","ror":"https://ror.org/01pnej532"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320336675","display_name":"National Research, Development and Innovation Office","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317831142.pdf","grobid_xml":"https://content.openalex.org/works/W4317831142.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W80748578","https://openalex.org/W138570049","https://openalex.org/W1489182588","https://openalex.org/W1549921087","https://openalex.org/W1556758605","https://openalex.org/W1565605888","https://openalex.org/W1606947757","https://openalex.org/W1671906456","https://openalex.org/W1914280947","https://openalex.org/W1968139400","https://openalex.org/W1981530406","https://openalex.org/W1988786779","https://openalex.org/W2008059340","https://openalex.org/W2012949016","https://openalex.org/W2020084080","https://openalex.org/W2033495141","https://openalex.org/W2049378381","https://openalex.org/W2055280685","https://openalex.org/W2056944867","https://openalex.org/W2060979157","https://openalex.org/W2064491404","https://openalex.org/W2070603512","https://openalex.org/W2074473216","https://openalex.org/W2077195824","https://openalex.org/W2095867585","https://openalex.org/W2096021562","https://openalex.org/W2102529525","https://openalex.org/W2105649494","https://openalex.org/W2106550996","https://openalex.org/W2112755762","https://openalex.org/W2126525702","https://openalex.org/W2131347449","https://openalex.org/W2133167066","https://openalex.org/W2136479434","https://openalex.org/W2143835145","https://openalex.org/W2144014661","https://openalex.org/W2147381804","https://openalex.org/W2148958646","https://openalex.org/W2153706317","https://openalex.org/W2161604082","https://openalex.org/W2165253681","https://openalex.org/W2165526004","https://openalex.org/W2170688845","https://openalex.org/W2171707538","https://openalex.org/W2172216479","https://openalex.org/W2177317049","https://openalex.org/W2542756470","https://openalex.org/W2556609853","https://openalex.org/W2744878627","https://openalex.org/W2767891136","https://openalex.org/W2810023675","https://openalex.org/W2899133544","https://openalex.org/W2901527454","https://openalex.org/W2926411573","https://openalex.org/W2942646248","https://openalex.org/W2954043109","https://openalex.org/W3002498794","https://openalex.org/W3004663246","https://openalex.org/W3005722875","https://openalex.org/W3009553415","https://openalex.org/W3097318633","https://openalex.org/W3098464343","https://openalex.org/W3107527779","https://openalex.org/W3109820229","https://openalex.org/W3120676751","https://openalex.org/W3122648990","https://openalex.org/W3124431209","https://openalex.org/W3133274832","https://openalex.org/W3154258817","https://openalex.org/W4200045218","https://openalex.org/W4200569894","https://openalex.org/W4200600971","https://openalex.org/W4205141565","https://openalex.org/W4205765055","https://openalex.org/W4206282864","https://openalex.org/W4206820858","https://openalex.org/W4206942993","https://openalex.org/W4207035552","https://openalex.org/W4210990859","https://openalex.org/W4212835119","https://openalex.org/W4213144403","https://openalex.org/W4213216442","https://openalex.org/W4214829762","https://openalex.org/W4220787997","https://openalex.org/W4221062947","https://openalex.org/W4223484562","https://openalex.org/W4224294665","https://openalex.org/W4226465230","https://openalex.org/W4244806628","https://openalex.org/W4249260944","https://openalex.org/W4249273120","https://openalex.org/W4298137335"],"related_works":["https://openalex.org/W3007305076","https://openalex.org/W2951279349","https://openalex.org/W2046736422","https://openalex.org/W2769306272","https://openalex.org/W2135602072","https://openalex.org/W2626653991","https://openalex.org/W2356638222","https://openalex.org/W2161532087","https://openalex.org/W2141177212","https://openalex.org/W2397094273"],"abstract_inverted_index":{"Abstract":[0],"Aim":[1],"This":[2,278],"study":[3,279],"outlines":[4],"an":[5,182,281],"efficient":[6,282],"weighted":[7,54,131,283],"network":[8,16,50,64,75,101,114,132,159,187,284,293],"centrality":[9,55,68,105,133,137,285],"measure":[10,106,138],"approach":[11,134,157,286,315],"and":[12,28,86,120,177,188,207,239,251,307,328],"its":[13],"application":[14],"in":[15,99,139,144,185,203,216,319],"pharmacology":[17,76,160,296],"for":[18,34,57,273,289],"exploring":[19],"mechanisms":[20],"of":[21,23,62,141,155,166,219,291,309,332],"action":[22],"the":[24,49,96,100,111,117,186,217,243,330],"Ruellia":[25,29],"prostrata":[26],"(RP)":[27],"bignoniiflora":[30],"(RB)":[31],"herbal":[32],"formula":[33],"treating":[35,274],"rheumatoid":[36,192,220,275],"arthritis.":[37,193,221,276],"Method":[38],"In":[39],"our":[40,72,104,129,156,314,333],"proposed":[41,130],"method":[42],"we":[43,109],"first":[44],"calculated":[45],"interconnectivity":[46],"scores":[47],"all":[48,58,248],"targets":[51,59,65,98,115,165,169,180,199,228,249],"then":[52,94],"computed":[53],"score":[56],"to":[60,74,158,191,233,247,305,326],"identify":[61,95],"major":[63,97,112,164,234,292],"based":[66,102,149],"on":[67,103,150,266],"score.":[69],"We":[70,93],"apply":[71],"technology":[73],"by":[77],"constructing":[78],"herb-compound-putative":[79,89],"target":[80,84,176],"network;":[81,85],"compound-putative":[82],"targets-RA":[83],"imbalance":[87],"multi-level":[88],"target-RA":[90],"target-PPI":[91],"network.":[92],"approach.":[107],"Finally":[108],"validated":[110],"identified":[113],"using":[116],"enrichment":[118],"analysis":[119,195],"a":[121,317],"molecular":[122,223],"docking":[123,224],"simulation.":[124,153],"Result":[125],"The":[126,222],"results":[127,300],"reveled":[128],"outperform":[135],"classical":[136],"identification":[140,290],"influential":[142],"nodes":[143],"four":[145,227],"real":[146],"complex":[147],"networks":[148],"SI":[151],"model":[152],"Application":[154],"shows":[161],"that":[162,197,301],"57":[163],"which":[167,213],"33":[168],"including":[170],"8":[171],"compositive":[172],"compounds,":[173],"15":[174],"putative":[175,198],"10":[178],"therapeutic":[179],"played":[181],"important":[183],"role":[184],"directly":[189],"linked":[190],"Enrichment":[194],"confirmed":[196],"were":[200,252],"frequently":[201],"involved":[202],"TNF,":[204],"CCR5,":[205],"IL-17":[206],"G-protein":[208],"coupled":[209],"receptors":[210],"signaling":[211],"pathways":[212],"are":[214,324],"critical":[215],"progression":[218],"simulation":[225],"indicated":[226],"had":[229,262],"significant":[230],"binding":[231,245],"affinity":[232,246],"protein":[235],"targets.":[236,294],"Glyceryl":[237],"diacetate-2-Oleate":[238],"Oleoyl":[240],"chloride":[241],"showed":[242],"best":[244],"proteins":[250],"within":[253],"Lipinski":[254],"limits.":[255],"ADMET":[256],"prediction":[257],"also":[258],"confirm":[259],"both":[260],"compounds":[261,272],"no":[263],"toxic":[264],"effect":[265],"human":[267],"hence":[268],"potential":[269],"lead":[270,303],"drug":[271,311],"Conclusion":[277],"developed":[280],"as":[287],"tool":[288],"Network":[295],"findings":[297],"provides":[298],"promising":[299],"could":[302],"us":[304],"design":[306],"discover":[308],"alternative":[310],"compounds.":[312],"Though":[313],"is":[316],"purely":[318],"silico":[320],"method,":[321],"clinical":[322],"experiments":[323],"required":[325],"test":[327],"validate":[329],"hypotheses":[331],"computational":[334],"methods.":[335]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2023-01-24T00:00:00"}