{"id":"https://openalex.org/W3187238434","doi":"https://doi.org/10.1007/s41109-022-00510-x","title":"Interaction networks from discrete event data by Poisson multivariate mutual information estimation and information flow with applications from gene expression data","display_name":"Interaction networks from discrete event data by Poisson multivariate mutual information estimation and information flow with applications from gene expression data","publication_year":2022,"publication_date":"2022-10-11","ids":{"openalex":"https://openalex.org/W3187238434","doi":"https://doi.org/10.1007/s41109-022-00510-x","mag":"3187238434"},"language":"en","primary_location":{"id":"doi:10.1007/s41109-022-00510-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-022-00510-x","pdf_url":"https://appliednetsci.springeropen.com/counter/pdf/10.1007/s41109-022-00510-x","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://appliednetsci.springeropen.com/counter/pdf/10.1007/s41109-022-00510-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081801559","display_name":"Jeremie Fish","orcid":"https://orcid.org/0000-0002-1236-742X"},"institutions":[{"id":"https://openalex.org/I16944753","display_name":"Clarkson University","ror":"https://ror.org/03rwgpn18","country_code":"US","type":"education","lineage":["https://openalex.org/I16944753"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremie Fish","raw_affiliation_strings":["Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA"],"affiliations":[{"raw_affiliation_string":"Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004502095","display_name":"Jie Sun","orcid":"https://orcid.org/0000-0003-2553-1804"},"institutions":[{"id":"https://openalex.org/I16944753","display_name":"Clarkson University","ror":"https://ror.org/03rwgpn18","country_code":"US","type":"education","lineage":["https://openalex.org/I16944753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Sun","raw_affiliation_strings":["Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA"],"affiliations":[{"raw_affiliation_string":"Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003961936","display_name":"Erik M. Bollt","orcid":"https://orcid.org/0000-0001-7083-7592"},"institutions":[{"id":"https://openalex.org/I16944753","display_name":"Clarkson University","ror":"https://ror.org/03rwgpn18","country_code":"US","type":"education","lineage":["https://openalex.org/I16944753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Bollt","raw_affiliation_strings":["Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA"],"affiliations":[{"raw_affiliation_string":"Clarkson Center for Complex Systems Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Clarkson University, 8 Clarkson Avenue, Potsdam, New York, 13699, USA","institution_ids":["https://openalex.org/I16944753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081801559"],"corresponding_institution_ids":["https://openalex.org/I16944753"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00200597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5648658275604248},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.5361383557319641},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.4710896909236908},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.4390111267566681},{"id":"https://openalex.org/keywords/point-process","display_name":"Point process","score":0.43846607208251953},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4376526176929474},{"id":"https://openalex.org/keywords/event","display_name":"Event (particle physics)","score":0.41857436299324036},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.34618616104125977},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3234408497810364},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.21428170800209045},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20647886395454407}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5648658275604248},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.5361383557319641},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.4710896909236908},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.4390111267566681},{"id":"https://openalex.org/C88871306","wikidata":"https://www.wikidata.org/wiki/Q7208287","display_name":"Point process","level":2,"score":0.43846607208251953},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4376526176929474},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.41857436299324036},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.34618616104125977},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3234408497810364},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21428170800209045},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20647886395454407},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s41109-022-00510-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-022-00510-x","pdf_url":"https://appliednetsci.springeropen.com/counter/pdf/10.1007/s41109-022-00510-x","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ad553e2829bd4528a09a999b49134299","is_oa":true,"landing_page_url":"https://doaj.org/article/ad553e2829bd4528a09a999b49134299","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Network Science, Vol 7, Iss 1, Pp 1-22 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s41109-022-00510-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-022-00510-x","pdf_url":"https://appliednetsci.springeropen.com/counter/pdf/10.1007/s41109-022-00510-x","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4048728441","display_name":null,"funder_award_id":"N68164-EG","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3187238434.pdf","grobid_xml":"https://content.openalex.org/works/W3187238434.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W614362261","https://openalex.org/W1976324983","https://openalex.org/W1978812719","https://openalex.org/W1980345828","https://openalex.org/W1992721855","https://openalex.org/W1995875735","https://openalex.org/W2000534401","https://openalex.org/W2036092381","https://openalex.org/W2041782669","https://openalex.org/W2054924908","https://openalex.org/W2062644604","https://openalex.org/W2071857414","https://openalex.org/W2072372077","https://openalex.org/W2084547117","https://openalex.org/W2087326716","https://openalex.org/W2092939357","https://openalex.org/W2110773510","https://openalex.org/W2129159585","https://openalex.org/W2132555912","https://openalex.org/W2133530320","https://openalex.org/W2135836598","https://openalex.org/W2142029338","https://openalex.org/W2153478504","https://openalex.org/W2159402338","https://openalex.org/W2162422091","https://openalex.org/W2193015782","https://openalex.org/W2210387432","https://openalex.org/W2256158415","https://openalex.org/W2346956614","https://openalex.org/W2478708596","https://openalex.org/W2548429415","https://openalex.org/W2557699161","https://openalex.org/W2884025810","https://openalex.org/W2962919278","https://openalex.org/W3098410656","https://openalex.org/W3105301591","https://openalex.org/W3123099417","https://openalex.org/W3126077909","https://openalex.org/W3211748989","https://openalex.org/W4210852193","https://openalex.org/W4239953570"],"related_works":["https://openalex.org/W2466816617","https://openalex.org/W1970834875","https://openalex.org/W3174028392","https://openalex.org/W842936808","https://openalex.org/W4287880334","https://openalex.org/W2000517284","https://openalex.org/W4366700029","https://openalex.org/W4298392797","https://openalex.org/W1979678609","https://openalex.org/W2180122548"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"this":[2,134],"work,":[3],"we":[4,55],"introduce":[5],"a":[6,73,166],"new":[7,98],"methodology":[8],"for":[9,88,133],"inferring":[10,160],"the":[11,68,81,97,105,109,116,129,146,161,177,181,185,194],"interaction":[12],"structure":[13,132],"of":[14,136,148],"discrete":[15,36,89],"valued":[16],"time":[17],"series":[18],"which":[19],"are":[20,27,43,85],"Poisson":[21,75,100,178],"distributed.":[22],"While":[23],"most":[24],"related":[25],"methods":[26,78,187],"premised":[28],"on":[29,57,193],"continuous":[30],"state":[31],"stochastic":[32,41,137],"processes,":[33,90],"in":[34,152],"fact,":[35],"and":[37,45,91,157,188],"counting":[38],"event":[39],"oriented":[40],"process":[42],"natural":[44],"common,":[46],"so":[47],"called":[48],"time-point":[49],"processes.":[50],"An":[51],"important":[52],"application":[53],"that":[54,67,139],"focus":[56],"here":[58,103],"is":[59,64,70],"gene":[60],"expression,":[61],"where":[62],"it":[63],"often":[65],"assumed":[66],"data":[69,93,173,197],"generated":[71],"from":[72,165],"multivariate":[74],"distribution.":[76],"Nonparameteric":[77],"such":[79],"as":[80,104],"popular":[82],"k-nearest":[83],"neighbors":[84],"slow":[86],"converging":[87],"thus":[92],"hungry.":[94],"Now,":[95],"with":[96,115,154],"multi-variate":[99],"estimator":[101],"developed":[102],"core":[106],"computational":[107],"engine,":[108],"causation":[110],"entropy":[111],"(CSE)":[112],"principle,":[113],"together":[114],"associated":[117],"greedy":[118],"search":[119],"algorithm":[120],"optimal":[121],"CSE":[122],"(oCSE)":[123],"allows":[124],"us":[125],"to":[126],"efficiently":[127],"infer":[128],"true":[130],"network":[131,164],"class":[135],"processes":[138],"were":[140],"previously":[141,190],"not":[142],"practical.":[143],"We":[144,175],"illustrate":[145],"power":[147],"our":[149],"method,":[150],"first":[151],"benchmarking":[153],"synthetic":[155],"datum,":[156],"then":[158],"by":[159],"genetic":[162],"factors":[163],"breast":[167,195],"cancer":[168,196],"micro-ribonucleic":[169],"acid":[170],"sequence":[171],"count":[172],"set.":[174,198],"show":[176],"oCSE":[179],"gives":[180],"best":[182],"performance":[183],"among":[184],"tested":[186],"discovers":[189],"known":[191],"interactions":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
