{"id":"https://openalex.org/W2990872860","doi":"https://doi.org/10.1007/s41109-019-0225-1","title":"Penalized inference of the hematopoietic cell differentiation network via high-dimensional clonal tracking","display_name":"Penalized inference of the hematopoietic cell differentiation network via high-dimensional clonal tracking","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2990872860","doi":"https://doi.org/10.1007/s41109-019-0225-1","mag":"2990872860"},"language":"en","primary_location":{"id":"doi:10.1007/s41109-019-0225-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-019-0225-1","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-019-0225-1","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-019-0225-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076171905","display_name":"Danilo Pellin","orcid":"https://orcid.org/0000-0002-2647-0508"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Danilo Pellin","raw_affiliation_strings":["Dana-Farber, Harvard Medical School, 1 Jimmy Fund Way, Boston, 02115, MA, USA","University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber, Harvard Medical School, 1 Jimmy Fund Way, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046553728","display_name":"Luca Biasco","orcid":"https://orcid.org/0000-0003-4022-7640"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Luca Biasco","raw_affiliation_strings":["Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Harvard Medical School, Boston, 02115, MA, USA","University College of London (UCL), Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, WC1N 1EH, United Kingdom","Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, 02115, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Harvard Medical School, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I4210166317"]},{"raw_affiliation_string":"University College of London (UCL), Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, WC1N 1EH, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I4210166317","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056887177","display_name":"Alessandro Aiuti","orcid":"https://orcid.org/0000-0002-5398-1717"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Aiuti","raw_affiliation_strings":["Medicine, Universita\u2019 Vita Salute San Raffaele, Milano, Italy","San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Universita\u2019 Vita Salute San Raffaele, Milano, Italy","institution_ids":["https://openalex.org/I154387261"]},{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milano, Italy","institution_ids":["https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Clelia Di Serio","orcid":null},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Clelia Di Serio","raw_affiliation_strings":["University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068403840","display_name":"Ernst C. Wit","orcid":"https://orcid.org/0000-0002-3671-9610"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH","NL"],"is_corresponding":true,"raw_author_name":"Ernst C. Wit","raw_affiliation_strings":["Bernoulli Institute, University of Groningen, Nijenborgh 9, Groningen, 9747 AG, Netherlands","Institute of Computational Science, Universit\u00e0 della Svizzera italiana, Via G. Buffi 13, Lugano, 6900, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3671-9610","affiliations":[{"raw_affiliation_string":"Bernoulli Institute, University of Groningen, Nijenborgh 9, Groningen, 9747 AG, Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"Institute of Computational Science, Universit\u00e0 della Svizzera italiana, Via G. Buffi 13, Lugano, 6900, Switzerland","institution_ids":["https://openalex.org/I57201433"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068403840"],"corresponding_institution_ids":["https://openalex.org/I169381384","https://openalex.org/I57201433"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":0.4272,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.63125491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5626128315925598},{"id":"https://openalex.org/keywords/statistical-inference","display_name":"Statistical inference","score":0.5332393646240234},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.466420978307724},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.45932337641716003},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.4412328004837036},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43660491704940796},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.42075207829475403},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4039013683795929},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.38498643040657043},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.2526041865348816},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19164156913757324},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.17143231630325317},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09785911440849304}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5626128315925598},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.5332393646240234},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.466420978307724},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.45932337641716003},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.4412328004837036},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43660491704940796},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42075207829475403},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4039013683795929},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.38498643040657043},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.2526041865348816},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19164156913757324},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.17143231630325317},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09785911440849304},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s41109-019-0225-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-019-0225-1","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-019-0225-1","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},{"id":"pmh:oai:pure.rug.nl:openaire/d5e1fdfc-da95-4583-8e04-8add0ca6ce21","is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/d5e1fdfc-da95-4583-8e04-8add0ca6ce21","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pellin, D, Biasco, L, Aiuti, A, Di Serio, M C & Wit, E C 2019, 'Penalized inference of the hematopoietic cell differentiation network via high-dimensional clonal tracking', Applied Network Science, vol. 4, no. 1, 115. https://doi.org/10.1007/s41109-019-0225-1","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:zenodo.org:24541","is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/24541","pdf_url":"https://zenodo.org/record/24541","source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:50d0f42449524512b7c4f8691d42e93e","is_oa":false,"landing_page_url":"https://doaj.org/article/50d0f42449524512b7c4f8691d42e93e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Network Science, Vol 4, Iss 1, Pp 1-26 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s41109-019-0225-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-019-0225-1","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-019-0225-1","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990872860.pdf","grobid_xml":"https://content.openalex.org/works/W2990872860.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W174227552","https://openalex.org/W1484033701","https://openalex.org/W1499965417","https://openalex.org/W1776790137","https://openalex.org/W1856430332","https://openalex.org/W1980867815","https://openalex.org/W1990381576","https://openalex.org/W1993307629","https://openalex.org/W2029611195","https://openalex.org/W2033079433","https://openalex.org/W2041465634","https://openalex.org/W2045782147","https://openalex.org/W2047576169","https://openalex.org/W2059114294","https://openalex.org/W2074682976","https://openalex.org/W2092633851","https://openalex.org/W2100555030","https://openalex.org/W2102787760","https://openalex.org/W2114849571","https://openalex.org/W2123122060","https://openalex.org/W2135046866","https://openalex.org/W2142159826","https://openalex.org/W2155418451","https://openalex.org/W2328151902","https://openalex.org/W2342177264","https://openalex.org/W2400758624","https://openalex.org/W2484638602","https://openalex.org/W2522697856","https://openalex.org/W2582743722","https://openalex.org/W2893247352","https://openalex.org/W2987803397","https://openalex.org/W4229530126","https://openalex.org/W4232995451"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W4321636575","https://openalex.org/W2357796999","https://openalex.org/W2045526782","https://openalex.org/W137830373","https://openalex.org/W3000984192","https://openalex.org/W4286952477","https://openalex.org/W4321348134","https://openalex.org/W2103073163","https://openalex.org/W3102283898"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"During":[2],"their":[3],"lifespan,":[4],"stem-":[5],"or":[6],"progenitor":[7],"cells":[8],"have":[9,158],"the":[10,37,58,63,81,132,147,195,211],"ability":[11],"to":[12,50,56,68,170,183],"differentiate":[13],"into":[14],"more":[15],"committed":[16],"cell":[17,38,59,200],"lineages.":[18],"Understanding":[19],"this":[20,47],"process":[21,40,61,122],"can":[22],"be":[23],"key":[24],"in":[25,97,146,181,186,210],"treating":[26],"certain":[27],"diseases.":[28],"However,":[29],"up":[30],"until":[31],"now":[32],"only":[33],"limited":[34],"information":[35],"about":[36],"differentiation":[39,60,82,201],"is":[41,49,105,138],"known.":[42],"Aim":[43],"The":[44,102,154,190],"goal":[45],"of":[46,80,111,117,163,199],"paper":[48],"present":[51],"a":[52,70,87,142,164,171,176,204],"statistical":[53],"framework":[54],"able":[55],"describe":[57],"at":[62],"single":[64],"clone":[65],"level":[66],"and":[67,77,100,167,202],"provide":[69],"corresponding":[71],"inferential":[72,103],"procedure":[73,104],"for":[74,114],"parameters":[75],"estimation":[76],"structure":[78,192],"reconstruction":[79],"network.":[83],"Approach":[84],"We":[85],"propose":[86],"multidimensional,":[88],"continuous-time":[89],"Markov":[90],"model":[91,207],"with":[92],"density-dependent":[93],"transition":[94],"probabilities":[95],"linear":[96],"sub-population":[98],"sizes":[99],"rates.":[101],"based":[106],"on":[107],"an":[108],"iterative":[109],"calculation":[110],"approximated":[112],"solutions":[113],"two":[115],"systems":[116],"ordinary":[118],"differential":[119],"equations,":[120],"describing":[121],"moments":[123],"evolution":[124],"over":[125],"time,":[126],"that":[127],"are":[128],"analytically":[129],"derived":[130,174],"from":[131,175],"process\u2019":[133],"master":[134],"equation.":[135],"Network":[136],"sparsity":[137],"induced":[139],"by":[140,161],"adding":[141],"SCAD-based":[143],"penalization":[144],"term":[145],"generalized":[148],"least":[149],"squares":[150],"objective":[151],"function.":[152],"Results":[153],"methods":[155],"proposed":[156,209],"here":[157],"been":[159],"tested":[160],"means":[162],"simulation":[165],"study":[166],"then":[168],"applied":[169],"data":[172],"set":[173],"gene":[177],"therapy":[178],"clinical":[179],"trial,":[180],"order":[182],"investigate":[184],"hematopoiesis":[185],"humans,":[187],"in-vivo":[188],".":[189],"hematopoietic":[191],"estimated":[193],"contradicts":[194],"classical":[196],"dichotomy":[197],"theory":[198],"supports":[203],"novel":[205],"myeloid-based":[206],"recently":[208],"literature.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
