{"id":"https://openalex.org/W2900225999","doi":"https://doi.org/10.1007/s41109-018-0101-4","title":"Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data","display_name":"Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data","publication_year":2018,"publication_date":"2018-11-07","ids":{"openalex":"https://openalex.org/W2900225999","doi":"https://doi.org/10.1007/s41109-018-0101-4","mag":"2900225999","pmid":"https://pubmed.ncbi.nlm.nih.gov/30465022"},"language":"en","primary_location":{"id":"doi:10.1007/s41109-018-0101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-018-0101-4","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-018-0101-4","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-018-0101-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103217962","display_name":"Babak Fotouhi","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210109333","display_name":"Evolutionary Genomics (United States)","ror":"https://ror.org/021z7gb33","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109333"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Babak Fotouhi","raw_affiliation_strings":["1Program for Evolutionary Dynamics, Harvard University, Cambridge, USA","Program for Evolutionary Dynamics, Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Program for Evolutionary Dynamics, Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I4210109333"]},{"raw_affiliation_string":"Program for Evolutionary Dynamics, Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073204434","display_name":"Naghmeh Momeni","orcid":"https://orcid.org/0000-0003-2911-1911"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naghmeh Momeni","raw_affiliation_strings":["2Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA","Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059990151","display_name":"Maria A. Riolo","orcid":"https://orcid.org/0000-0002-9958-3351"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria A. Riolo","raw_affiliation_strings":["3Center for the Study of Complex Systems, University of Michigan, Ann Arbor, Michigan USA","Center for the Study of Complex Systems, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Center for the Study of Complex Systems, University of Michigan, Ann Arbor, Michigan USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Center for the Study of Complex Systems, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027694435","display_name":"David L. Buckeridge","orcid":"https://orcid.org/0000-0003-1817-5047"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David L. Buckeridge","raw_affiliation_strings":["4Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada","Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103217962"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210109333"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":1.9579,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.86511931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comorbidity","display_name":"Comorbidity","score":0.8655992746353149},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6160406470298767},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.6139035820960999},{"id":"https://openalex.org/keywords/longitudinal-data","display_name":"Longitudinal data","score":0.4782492220401764},{"id":"https://openalex.org/keywords/metropolitan-area","display_name":"Metropolitan area","score":0.45556285977363586},{"id":"https://openalex.org/keywords/null-hypothesis","display_name":"Null hypothesis","score":0.417985200881958},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.4158340096473694},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41376858949661255},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3392638564109802},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26069873571395874},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.23895785212516785},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.17495805025100708},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15266484022140503},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08174994587898254}],"concepts":[{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.8655992746353149},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6160406470298767},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.6139035820960999},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.4782492220401764},{"id":"https://openalex.org/C158739034","wikidata":"https://www.wikidata.org/wiki/Q1907114","display_name":"Metropolitan area","level":2,"score":0.45556285977363586},{"id":"https://openalex.org/C191988596","wikidata":"https://www.wikidata.org/wiki/Q628374","display_name":"Null hypothesis","level":2,"score":0.417985200881958},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4158340096473694},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41376858949661255},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3392638564109802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26069873571395874},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.23895785212516785},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17495805025100708},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15266484022140503},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08174994587898254},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1007/s41109-018-0101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-018-0101-4","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-018-0101-4","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},{"id":"pmid:30465022","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30465022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied network science","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/146189","is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/146189","pdf_url":"https://hdl.handle.net/2027.42/146189","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5202231","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6223974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6223974","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6223974","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Appl Netw Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:777d70b546cf495abb950bcb8009c80c","is_oa":true,"landing_page_url":"https://doaj.org/article/777d70b546cf495abb950bcb8009c80c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Network Science, Vol 3, Iss 1, Pp 1-34 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s41109-018-0101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s41109-018-0101-4","pdf_url":"https://appliednetsci.springeropen.com/track/pdf/10.1007/s41109-018-0101-4","source":{"id":"https://openalex.org/S3035517252","display_name":"Applied Network Science","issn_l":"2364-8228","issn":["2364-8228"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Network Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2900225999.pdf","grobid_xml":"https://content.openalex.org/works/W2900225999.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W100408257","https://openalex.org/W1510786383","https://openalex.org/W1532325895","https://openalex.org/W1543136715","https://openalex.org/W1544009106","https://openalex.org/W1559965908","https://openalex.org/W1930572491","https://openalex.org/W1964905434","https://openalex.org/W1985714703","https://openalex.org/W1995835378","https://openalex.org/W1997239568","https://openalex.org/W1997468904","https://openalex.org/W2000042664","https://openalex.org/W2000949271","https://openalex.org/W2003447360","https://openalex.org/W2010707723","https://openalex.org/W2011123928","https://openalex.org/W2031627786","https://openalex.org/W2038793346","https://openalex.org/W2039452483","https://openalex.org/W2041073071","https://openalex.org/W2042772321","https://openalex.org/W2048169322","https://openalex.org/W2056782561","https://openalex.org/W2059957083","https://openalex.org/W2066636486","https://openalex.org/W2068234084","https://openalex.org/W2074187421","https://openalex.org/W2074242226","https://openalex.org/W2083045667","https://openalex.org/W2087194317","https://openalex.org/W2087419523","https://openalex.org/W2090018148","https://openalex.org/W2092084789","https://openalex.org/W2095281220","https://openalex.org/W2108066788","https://openalex.org/W2121671360","https://openalex.org/W2124244440","https://openalex.org/W2129000670","https://openalex.org/W2137200212","https://openalex.org/W2138563650","https://openalex.org/W2138621811","https://openalex.org/W2148015259","https://openalex.org/W2152415104","https://openalex.org/W2154027576","https://openalex.org/W2160882943","https://openalex.org/W2167950626","https://openalex.org/W2310319955","https://openalex.org/W2318545565","https://openalex.org/W2321700603","https://openalex.org/W2327355331","https://openalex.org/W2513567506","https://openalex.org/W2582460218","https://openalex.org/W2583143836","https://openalex.org/W2612698617","https://openalex.org/W2767812922","https://openalex.org/W2803437449","https://openalex.org/W2949367643","https://openalex.org/W3012570452","https://openalex.org/W3102510951","https://openalex.org/W3103362336","https://openalex.org/W4235501633","https://openalex.org/W4240116026","https://openalex.org/W4255097306","https://openalex.org/W4301006716","https://openalex.org/W6608252986","https://openalex.org/W6636894290"],"related_works":["https://openalex.org/W4212929323","https://openalex.org/W2045046253","https://openalex.org/W2000995042","https://openalex.org/W2494740635","https://openalex.org/W1632599465","https://openalex.org/W1563545158","https://openalex.org/W2115206115","https://openalex.org/W2091545482","https://openalex.org/W3177269507","https://openalex.org/W2379499532"],"abstract_inverted_index":{"Tools":[0],"from":[1,29],"network":[2,45,68,97],"science":[3,98],"can":[4],"be":[5],"utilized":[6],"to":[7,39,46,53,79,100,123,137],"study":[8],"relations":[9,42,163],"between":[10,108],"diseases.":[11],"Different":[12],"studies":[13,62],"focus":[14],"on":[15],"different":[16,77,155,158],"types":[17],"of":[18,22,33,49,66,91,127,150,160,173],"inter-disease":[19],"linkages.":[20],"One":[21],"them":[23],"is":[24,63],"the":[25,64,67,106,109,124,138,145,148,151,161],"comorbidity":[26,41,162],"patterns":[27],"derived":[28],"large-scale":[30],"longitudinal":[31],"data":[32,126],"hospital":[34],"discharge":[35],"records.":[36],"Researchers":[37],"seek":[38],"describe":[40],"as":[43],"a":[44,82],"characterize":[47],"pathways":[48],"disease":[50],"progressions":[51],"and":[52,116,157],"predict":[54],"future":[55],"risks.":[56],"The":[57],"first":[58],"step":[59],"in":[60,96,147],"such":[61,81],"construction":[65],"itself,":[69],"which":[70],"subsequent":[71],"analyses":[72],"rest":[73],"upon.":[74],"There":[75],"are":[76],"ways":[78],"build":[80],"network.":[83],"In":[84],"this":[85],"paper,":[86],"we":[87],"provide":[88],"an":[89],"overview":[90],"several":[92,170],"existing":[93],"statistical":[94],"approaches":[95],"applicable":[99],"weighted":[101],"directed":[102],"networks.":[103],"We":[104,119,143,167],"discuss":[105,144],"differences":[107,146],"null":[110],"models":[111,114],"that":[112,164],"these":[113,121,174],"assume":[115],"their":[117],"applications.":[118],"apply":[120],"methods":[122],"inpatient":[125],"approximately":[128,133],"one":[129],"million":[130],"people,":[131],"spanning":[132],"17":[134],"years,":[135],"pertaining":[136],"Montreal":[139],"Census":[140],"Metropolitan":[141],"Area.":[142],"structure":[149],"networks":[152],"built":[153],"by":[154],"methods,":[156],"features":[159],"they":[165],"extract.":[166],"also":[168],"present":[169],"example":[171],"applications":[172],"methods.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}