{"id":"https://openalex.org/W4417083589","doi":"https://doi.org/10.1007/s40747-025-02177-0","title":"Organfit: a multi-scale convolutional model with ellipse fitting for organoid identification","display_name":"Organfit: a multi-scale convolutional model with ellipse fitting for organoid identification","publication_year":2025,"publication_date":"2025-12-06","ids":{"openalex":"https://openalex.org/W4417083589","doi":"https://doi.org/10.1007/s40747-025-02177-0"},"language":"en","primary_location":{"id":"doi:10.1007/s40747-025-02177-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40747-025-02177-0","pdf_url":null,"source":{"id":"https://openalex.org/S3035462843","display_name":"Complex & Intelligent Systems","issn_l":"2198-6053","issn":["2198-6053","2199-4536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complex & Intelligent Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s40747-025-02177-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101885439","display_name":"Le Tong","orcid":"https://orcid.org/0000-0002-4861-4787"},"institutions":[{"id":"https://openalex.org/I21945476","display_name":"Shanghai Normal University","ror":"https://ror.org/01cxqmw89","country_code":"CN","type":"education","lineage":["https://openalex.org/I21945476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Tong","raw_affiliation_strings":["The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-4861-4787","affiliations":[{"raw_affiliation_string":"The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China","institution_ids":["https://openalex.org/I21945476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381226","display_name":"Xinran Li","orcid":"https://orcid.org/0000-0003-3226-5719"},"institutions":[{"id":"https://openalex.org/I21945476","display_name":"Shanghai Normal University","ror":"https://ror.org/01cxqmw89","country_code":"CN","type":"education","lineage":["https://openalex.org/I21945476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinran Li","raw_affiliation_strings":["The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China","institution_ids":["https://openalex.org/I21945476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037017610","display_name":"Tao Shu","orcid":"https://orcid.org/0000-0002-0173-2559"},"institutions":[{"id":"https://openalex.org/I21945476","display_name":"Shanghai Normal University","ror":"https://ror.org/01cxqmw89","country_code":"CN","type":"education","lineage":["https://openalex.org/I21945476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Shu","raw_affiliation_strings":["The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai, China","institution_ids":["https://openalex.org/I21945476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609338","display_name":"Xun Deng","orcid":"https://orcid.org/0009-0009-6552-8942"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Deng","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100526584","display_name":"Feng Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Feng Tan","raw_affiliation_strings":["Al and Quantum Lab, Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Al and Quantum Lab, Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116548905","display_name":"Zemin Kuang","orcid":"https://orcid.org/0009-0005-1540-4555"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zemin Kuang","raw_affiliation_strings":["Beijing Anzhen Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Anzhen Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210119028","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017713277","display_name":"Yu\u2010An Huang","orcid":"https://orcid.org/0000-0002-5346-2394"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-An Huang","raw_affiliation_strings":["Northwestern Polytechnical University, Xi\u2019an, China","Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuhong You","raw_affiliation_strings":["Northwestern Polytechnical University, Xi\u2019an, China","Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008221100","display_name":"Lun Hu","orcid":"https://orcid.org/0000-0002-1591-8549"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lun Hu","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078808331","display_name":"Pengwei Hu","orcid":"https://orcid.org/0000-0001-5974-7932"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pengwei Hu","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048640231","display_name":"Wei Du","orcid":"https://orcid.org/0000-0003-3976-2275"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Laboratory of Smart Manufacturing in Energy Chemical Process, East China University of Science and Technology, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Smart Manufacturing in Energy Chemical Process, East China University of Science and Technology, Shanghai, China","institution_ids":["https://openalex.org/I143593769"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5078808331"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108","https://openalex.org/I4210165038"],"apc_list":{"value":1320,"currency":"GBP","value_usd":1619},"apc_paid":{"value":1320,"currency":"GBP","value_usd":1619},"fwci":1.0012,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83939336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"12","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.43549999594688416,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.43549999594688416,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.193900004029274,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.09960000216960907,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organoid","display_name":"Organoid","score":0.9617000222206116},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4544000029563904},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44519999623298645},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.43650001287460327},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.3986999988555908},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.39100000262260437},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.34139999747276306}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9617000222206116},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.734499990940094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6492999792098999},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5199999809265137},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5042999982833862},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4544000029563904},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44519999623298645},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.43650001287460327},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.3986999988555908},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.3118000030517578},{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C5339829","wikidata":"https://www.wikidata.org/wiki/Q1425977","display_name":"Machine vision","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.25760000944137573}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s40747-025-02177-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40747-025-02177-0","pdf_url":null,"source":{"id":"https://openalex.org/S3035462843","display_name":"Complex & Intelligent Systems","issn_l":"2198-6053","issn":["2198-6053","2199-4536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complex & Intelligent Systems","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f3031606c202437ba00587737bbee748","is_oa":true,"landing_page_url":"https://doaj.org/article/f3031606c202437ba00587737bbee748","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Complex & Intelligent Systems, Vol 12, Iss 2, Pp 1-22 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s40747-025-02177-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40747-025-02177-0","pdf_url":null,"source":{"id":"https://openalex.org/S3035462843","display_name":"Complex & Intelligent Systems","issn_l":"2198-6053","issn":["2198-6053","2199-4536"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complex & Intelligent Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2828312957","display_name":null,"funder_award_id":"62302495","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4711008006","display_name":null,"funder_award_id":"E33B9401","funder_id":"https://openalex.org/F4320329872","funder_display_name":"Xinjiang Tianchi Doctoral Project"},{"id":"https://openalex.org/G573291307","display_name":null,"funder_award_id":"2023D01E15","funder_id":"https://openalex.org/F4320328898","funder_display_name":"Natural Science Foundation of Xinjiang"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328898","display_name":"Natural Science Foundation of Xinjiang","ror":null},{"id":"https://openalex.org/F4320329872","display_name":"Xinjiang Tianchi Doctoral Project","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1125523343","https://openalex.org/W1939349075","https://openalex.org/W2140427427","https://openalex.org/W2524820142","https://openalex.org/W2580231450","https://openalex.org/W2602807759","https://openalex.org/W2616102727","https://openalex.org/W2625621508","https://openalex.org/W2766487614","https://openalex.org/W2773981699","https://openalex.org/W2795334574","https://openalex.org/W2900936384","https://openalex.org/W2928133111","https://openalex.org/W2963881378","https://openalex.org/W2990995235","https://openalex.org/W3000722911","https://openalex.org/W3012383722","https://openalex.org/W3094746540","https://openalex.org/W3119958829","https://openalex.org/W3121461812","https://openalex.org/W3175171157","https://openalex.org/W4213171111","https://openalex.org/W4221138999","https://openalex.org/W4308624890","https://openalex.org/W4311481072","https://openalex.org/W4315836269","https://openalex.org/W4366483395","https://openalex.org/W4387211518","https://openalex.org/W4388652864","https://openalex.org/W4392748137","https://openalex.org/W4394988245"],"related_works":[],"abstract_inverted_index":{"Organoids":[0],"hold":[1],"significant":[2],"potential":[3],"and":[4,15,28,59,106,123,135,147,152,171],"scientific":[5],"value":[6],"in":[7,110],"areas":[8],"such":[9,32,53],"as":[10,33,54],"disease":[11],"modeling,":[12],"drug":[13,41],"screening,":[14],"regenerative":[16],"medicine.":[17],"During":[18],"cultivation,":[19],"researchers":[20],"monitor":[21],"the":[22,69,116,150,165],"development":[23],"of":[24,72,118,132,154],"organoids":[25,64,119,146],"through":[26],"imaging":[27],"apply":[29],"quantitative":[30],"methods,":[31],"cell":[34],"counting,":[35],"to":[36,104],"assess":[37],"key":[38],"metrics":[39],"like":[40],"response.":[42],"However,":[43],"existing":[44],"bright-field":[45],"image":[46,137],"processing":[47],"techniques":[48],"often":[49],"struggle":[50],"with":[51,120],"challenges":[52],"blurred":[55],"boundaries,":[56],"low":[57,136],"contrast,":[58],"noise":[60],"interference,":[61],"particularly":[62],"when":[63],"overlap.":[65],"These":[66],"limitations":[67],"hinder":[68],"accurate":[70,126],"segmentation":[71],"organoid":[73,95,155,161],"structures.":[74],"To":[75],"address":[76],"these":[77],"issues,":[78],"this":[79],"paper":[80],"proposes":[81],"an":[82,99],"innovative":[83],"approach":[84],"named":[85],"OrganFit,":[86],"which":[87],"integrates":[88],"a":[89,140],"multi-scale":[90],"convolutional":[91],"model":[92],"for":[93],"segmenting":[94],"regions,":[96],"followed":[97],"by":[98],"optimized":[100],"elliptical":[101],"fitting":[102,128],"principles":[103],"detect":[105],"screen":[107],"junction":[108],"points":[109],"overlapping":[111,145],"areas.":[112],"This":[113],"method":[114,167],"captures":[115],"features":[117],"varying":[121],"sizes":[122],"shapes,":[124],"enabling":[125],"contour":[127],"even":[129],"under":[130],"conditions":[131],"severe":[133],"overlap":[134],"contrast.":[138],"As":[139],"result,":[141],"it":[142],"effectively":[143],"distinguishes":[144],"significantly":[148],"enhances":[149],"accuracy":[151],"reliability":[153],"counting.":[156],"Experimental":[157],"results":[158],"across":[159,176],"multiple":[160],"datasets":[162],"demonstrate":[163],"that":[164],"proposed":[166],"maintains":[168],"stable":[169],"performance":[170],"robustness,":[172],"showing":[173],"adaptable":[174],"generalization":[175],"diverse":[177],"application":[178],"scenarios.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2025-12-06T00:00:00"}