{"id":"https://openalex.org/W2612469205","doi":"https://doi.org/10.1007/s40708-017-0067-5","title":"Multiscale modeling in the clinic: diseases of the brain and nervous system","display_name":"Multiscale modeling in the clinic: diseases of the brain and nervous system","publication_year":2017,"publication_date":"2017-05-09","ids":{"openalex":"https://openalex.org/W2612469205","doi":"https://doi.org/10.1007/s40708-017-0067-5","mag":"2612469205","pmid":"https://pubmed.ncbi.nlm.nih.gov/28488252"},"language":"en","primary_location":{"id":"doi:10.1007/s40708-017-0067-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-017-0067-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-017-0067-5.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-017-0067-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082122443","display_name":"William W. Lytton","orcid":"https://orcid.org/0000-0002-3727-2849"},"institutions":[{"id":"https://openalex.org/I4210117211","display_name":"Kings County Hospital Center","ror":"https://ror.org/02emy8e21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283621791","https://openalex.org/I4210117211"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William W. Lytton","raw_affiliation_strings":["Department of Physiology and Pharmacology and Neurology, SUNY Downstate, Kings County Hospital, Brooklyn, NY, 11203, USA. wwlytton@yahoo.com","Department of Physiology and Pharmacology and Neurology, SUNY Downstate, Kings County Hospital, Brooklyn, NY, 11203, USA"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology and Neurology, SUNY Downstate, Kings County Hospital, Brooklyn, NY, 11203, USA. wwlytton@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology and Pharmacology and Neurology, SUNY Downstate, Kings County Hospital, Brooklyn, NY, 11203, USA","institution_ids":["https://openalex.org/I4210117211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073973917","display_name":"Jeff Arle","orcid":null},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Arle","raw_affiliation_strings":["Harvard U, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Harvard U, Cambridge, MA, USA","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078220202","display_name":"Georgiy Bobashev","orcid":"https://orcid.org/0000-0003-2346-1400"},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"funder","lineage":["https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgiy Bobashev","raw_affiliation_strings":["RTI International, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"RTI International, Durham, NC, USA","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089789604","display_name":"Songbai Ji","orcid":"https://orcid.org/0000-0002-2886-5781"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songbai Ji","raw_affiliation_strings":["Thayer School of Engineering, Department of Surgery and of Orthopaedic Surgery, Geisel School of Medicine, Dartmouth College, Hanover, NH, 3755, USA"],"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Department of Surgery and of Orthopaedic Surgery, Geisel School of Medicine, Dartmouth College, Hanover, NH, 3755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043588438","display_name":"Tara Klassen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tara L. Klassen","raw_affiliation_strings":["U British Columbia, Vancouver, BC, Canada"],"affiliations":[{"raw_affiliation_string":"U British Columbia, Vancouver, BC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036646017","display_name":"Vasilis Z. Marmarelis","orcid":"https://orcid.org/0000-0003-1457-813X"},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasilis Z. Marmarelis","raw_affiliation_strings":["USC, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013431970","display_name":"James S. Schwaber","orcid":"https://orcid.org/0000-0003-0598-7345"},"institutions":[{"id":"https://openalex.org/I858669146","display_name":"Jefferson College","ror":"https://ror.org/04fcaga30","country_code":"US","type":"education","lineage":["https://openalex.org/I858669146"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Schwaber","raw_affiliation_strings":["Jefferson U, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Jefferson U, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I858669146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101537816","display_name":"Mohamed Sherif","orcid":"https://orcid.org/0000-0002-8951-1645"},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Mohamed A. Sherif","raw_affiliation_strings":["Ain Shams U Institute of Psychiatry, Cairo, Egypt","VA Connecticut Healthcare System, West Haven, CT, USA","Yale U, New Haven, CT, USA"],"affiliations":[{"raw_affiliation_string":"Ain Shams U Institute of Psychiatry, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"VA Connecticut Healthcare System, West Haven, CT, USA","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Yale U, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052151688","display_name":"Terence D. Sanger","orcid":"https://orcid.org/0000-0002-1837-6044"},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terence D. Sanger","raw_affiliation_strings":["USC, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1342924430"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5082122443"],"corresponding_institution_ids":["https://openalex.org/I4210117211"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":3.5132,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.92806942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"4","issue":"4","first_page":"219","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurorehabilitation","display_name":"Neurorehabilitation","score":0.7225503325462341},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7018285989761353},{"id":"https://openalex.org/keywords/computational-neuroscience","display_name":"Computational neuroscience","score":0.6804907321929932},{"id":"https://openalex.org/keywords/multiscale-modeling","display_name":"Multiscale modeling","score":0.5405911207199097},{"id":"https://openalex.org/keywords/clinical-neuroscience","display_name":"Clinical neuroscience","score":0.4912263751029968},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49090367555618286},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.46896401047706604},{"id":"https://openalex.org/keywords/systems-neuroscience","display_name":"Systems neuroscience","score":0.4595990777015686},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.45386648178100586},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.44738179445266724},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.39821264147758484},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3619021773338318},{"id":"https://openalex.org/keywords/neurology","display_name":"Neurology","score":0.346590131521225},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30617910623550415},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.229140967130661},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19846060872077942},{"id":"https://openalex.org/keywords/rehabilitation","display_name":"Rehabilitation","score":0.14519497752189636},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.13847759366035461},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11445346474647522}],"concepts":[{"id":"https://openalex.org/C47177892","wikidata":"https://www.wikidata.org/wiki/Q3510101","display_name":"Neurorehabilitation","level":3,"score":0.7225503325462341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7018285989761353},{"id":"https://openalex.org/C15286952","wikidata":"https://www.wikidata.org/wiki/Q8037925","display_name":"Computational neuroscience","level":2,"score":0.6804907321929932},{"id":"https://openalex.org/C141123601","wikidata":"https://www.wikidata.org/wiki/Q6935072","display_name":"Multiscale modeling","level":2,"score":0.5405911207199097},{"id":"https://openalex.org/C2081992","wikidata":"https://www.wikidata.org/wiki/Q5133838","display_name":"Clinical neuroscience","level":3,"score":0.4912263751029968},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49090367555618286},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46896401047706604},{"id":"https://openalex.org/C31288803","wikidata":"https://www.wikidata.org/wiki/Q2617516","display_name":"Systems neuroscience","level":5,"score":0.4595990777015686},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.45386648178100586},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.44738179445266724},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39821264147758484},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3619021773338318},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.346590131521225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30617910623550415},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.229140967130661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19846060872077942},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.14519497752189636},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.13847759366035461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11445346474647522},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.0},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s40708-017-0067-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-017-0067-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-017-0067-5.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},{"id":"pmid:28488252","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28488252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain informatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:7eb36534e1674f13a3d8a8adbf73be5d","is_oa":true,"landing_page_url":"https://doaj.org/article/7eb36534e1674f13a3d8a8adbf73be5d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Informatics, Vol 4, Iss 4, Pp 219-230 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4633173","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5709279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s40708-017-0067-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-017-0067-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-017-0067-5.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1052924134","display_name":null,"funder_award_id":"U01EB017695","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2375506980","display_name":null,"funder_award_id":"R21 NS088781","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2579690769","display_name":null,"funder_award_id":"NS092853","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3354284890","display_name":null,"funder_award_id":"NIBIB","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3746829199","display_name":null,"funder_award_id":"R01 NS092853","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3897364063","display_name":null,"funder_award_id":"EB017695","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4700852728","display_name":null,"funder_award_id":"R01 NS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7596427450","display_name":null,"funder_award_id":"R01MH086638","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7653585594","display_name":null,"funder_award_id":"R21 NS078607","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8222325735","display_name":null,"funder_award_id":"U01EB017695","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8404882895","display_name":null,"funder_award_id":"R01MH086638","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2612469205.pdf","grobid_xml":"https://content.openalex.org/works/W2612469205.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W10787140","https://openalex.org/W79503721","https://openalex.org/W90255704","https://openalex.org/W107436657","https://openalex.org/W138039427","https://openalex.org/W169853356","https://openalex.org/W1007681697","https://openalex.org/W1542503752","https://openalex.org/W1551911662","https://openalex.org/W1557242726","https://openalex.org/W1584323995","https://openalex.org/W1595581172","https://openalex.org/W1671225038","https://openalex.org/W1966474984","https://openalex.org/W1970473913","https://openalex.org/W1970911802","https://openalex.org/W1972889453","https://openalex.org/W1973116772","https://openalex.org/W1980528265","https://openalex.org/W1980621373","https://openalex.org/W1984116678","https://openalex.org/W1988128196","https://openalex.org/W2000871615","https://openalex.org/W2002475136","https://openalex.org/W2002850293","https://openalex.org/W2013472346","https://openalex.org/W2013846420","https://openalex.org/W2019739871","https://openalex.org/W2023646309","https://openalex.org/W2023721345","https://openalex.org/W2028084918","https://openalex.org/W2034108533","https://openalex.org/W2040490831","https://openalex.org/W2041630429","https://openalex.org/W2044147947","https://openalex.org/W2045738983","https://openalex.org/W2050534340","https://openalex.org/W2052889947","https://openalex.org/W2053127901","https://openalex.org/W2054084798","https://openalex.org/W2057019330","https://openalex.org/W2066848874","https://openalex.org/W2067870332","https://openalex.org/W2077044356","https://openalex.org/W2079164954","https://openalex.org/W2080929714","https://openalex.org/W2081530790","https://openalex.org/W2084074448","https://openalex.org/W2087356761","https://openalex.org/W2099498996","https://openalex.org/W2101964852","https://openalex.org/W2106912553","https://openalex.org/W2109130007","https://openalex.org/W2109528618","https://openalex.org/W2117490209","https://openalex.org/W2118901526","https://openalex.org/W2121999238","https://openalex.org/W2128872139","https://openalex.org/W2129976880","https://openalex.org/W2135271579","https://openalex.org/W2136592274","https://openalex.org/W2157728484","https://openalex.org/W2158935809","https://openalex.org/W2163234334","https://openalex.org/W2164846607","https://openalex.org/W2165417170","https://openalex.org/W2168067596","https://openalex.org/W2168639189","https://openalex.org/W2170533522","https://openalex.org/W2171234119","https://openalex.org/W2250857760","https://openalex.org/W2252452954","https://openalex.org/W2275095388","https://openalex.org/W2315534203","https://openalex.org/W2320969362","https://openalex.org/W2342110959","https://openalex.org/W2407583247","https://openalex.org/W2411366640","https://openalex.org/W2444021703"],"related_works":["https://openalex.org/W2159198487","https://openalex.org/W1593495836","https://openalex.org/W4383560353","https://openalex.org/W1533907798","https://openalex.org/W2274091502","https://openalex.org/W3082730045","https://openalex.org/W2165810797","https://openalex.org/W4210491869","https://openalex.org/W1577937936","https://openalex.org/W2598410160"],"abstract_inverted_index":{"Computational":[0],"neuroscience":[1,35],"is":[2,113],"a":[3,154,160],"field":[4],"that":[5,94,110,157],"traces":[6],"its":[7],"origins":[8],"to":[9,84,107,123,130,134,141,152,170],"the":[10,24,67,163,172,183],"efforts":[11],"of":[12,20,69,76,86,92,149,162,174,177,197,203],"Hodgkin":[13],"and":[14,42,62,73,79,88,100,187,219],"Huxley,":[15],"who":[16],"pioneered":[17],"quantitative":[18],"analysis":[19,117],"electrical":[21],"activity":[22],"in":[23,97,180],"nervous":[25],"system.":[26],"While":[27],"also":[28,168],"continuing":[29],"as":[30,47,159],"an":[31],"independent":[32],"field,":[33],"computational":[34,39],"has":[36,52],"combined":[37],"with":[38,66,115,127,138,146],"systems":[40],"biology,":[41],"neural":[43,63],"multiscale":[44,105],"modeling":[45,106,166,206],"arose":[46],"one":[48],"offshoot.":[49],"This":[50],"consolidation":[51],"added":[53],"electrical,":[54],"graphical,":[55],"dynamical":[56],"system,":[57],"learning":[58],"theory,":[59],"artificial":[60],"intelligence":[61],"network":[64],"viewpoints":[65],"microscale":[68],"cellular":[70],"biology":[71],"(neuronal":[72],"glial),":[74],"mesoscales":[75],"vascular,":[77],"immunological":[78],"neuronal":[80],"networks,":[81],"on":[82],"up":[83],"macroscales":[85],"cognition":[87],"behavior.":[89],"The":[90],"complexity":[91],"linkages":[93],"produces":[95],"pathophysiology":[96],"neurological,":[98],"neurosurgical":[99],"psychiatric":[101],"disease":[102,156,161],"will":[103,167],"require":[104],"provide":[108],"understanding":[109],"exceeds":[111],"what":[112],"possible":[114],"statistical":[116],"or":[118],"highly":[119],"simplified":[120],"models:":[121],"how":[122,129,133,140,151],"bring":[124],"together":[125],"pharmacotherapeutics":[126],"neurostimulation,":[128],"personalize":[131],"therapies,":[132],"combine":[135],"novel":[136],"therapies":[137],"neurorehabilitation,":[139,215],"interlace":[142],"periodic":[143],"diagnostic":[144],"updates":[145],"frequent":[147],"reevaluation":[148],"therapy,":[150],"understand":[153],"physical":[155],"manifests":[158],"mind.":[164],"Multiscale":[165],"help":[169],"extend":[171],"usefulness":[173],"animal":[175,188],"models":[176],"human":[178],"diseases":[179],"neuroscience,":[181],"where":[182],"disconnects":[184],"between":[185],"clinical":[186,201],"phenomenology":[189],"are":[190],"particularly":[191],"pronounced.":[192],"Here":[193],"we":[194],"cover":[195],"areas":[196],"particular":[198],"interest":[199],"for":[200],"application":[202],"these":[204],"new":[205],"neurotechnologies,":[207],"including":[208],"epilepsy,":[209],"traumatic":[210],"brain":[211],"injury,":[212],"ischemic":[213],"disease,":[214],"drug":[216],"addiction,":[217],"schizophrenia":[218],"neurostimulation.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}