{"id":"https://openalex.org/W2966629694","doi":"https://doi.org/10.1007/s40484-019-0175-8","title":"EpiFIT: functional interpretation of transcription factors based on combination of sequence and epigenetic information","display_name":"EpiFIT: functional interpretation of transcription factors based on combination of sequence and epigenetic information","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2966629694","doi":"https://doi.org/10.1007/s40484-019-0175-8","mag":"2966629694"},"language":"en","primary_location":{"id":"doi:10.1007/s40484-019-0175-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-019-0175-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s40484-019-0175-8","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s40484-019-0175-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029156207","display_name":"Shaoming Song","orcid":"https://orcid.org/0000-0001-8085-4476"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Shaoming Song","raw_affiliation_strings":["MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","MOE Key Laboratory of Bioinformatics","Department of Automation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics","institution_ids":["https://openalex.org/I4210148697"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101130056","display_name":"Hongfei Cui","orcid":"https://orcid.org/0000-0001-7143-674X"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Hongfei Cui","raw_affiliation_strings":["MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","Department of Automation, Tsinghua University, Beijing 100084, China","MOE Key Laboratory of Bioinformatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics","institution_ids":["https://openalex.org/I4210148697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046058016","display_name":"Shengquan Chen","orcid":"https://orcid.org/0000-0002-3503-9306"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Shengquan Chen","raw_affiliation_strings":["MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","Department of Automation, Tsinghua University, Beijing 100084, China","MOE Key Laboratory of Bioinformatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics","institution_ids":["https://openalex.org/I4210148697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393711","display_name":"Qiao Liu","orcid":"https://orcid.org/0000-0002-9781-3360"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Qiao Liu","raw_affiliation_strings":["MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","Department of Automation, Tsinghua University, Beijing 100084, China","MOE Key Laboratory of Bioinformatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics","institution_ids":["https://openalex.org/I4210148697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100623015","display_name":"Rui Jiang","orcid":"https://orcid.org/0000-0002-7533-3753"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","IN"],"is_corresponding":true,"raw_author_name":"Rui Jiang","raw_affiliation_strings":["MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","MOE Key Laboratory of Bioinformatics","Department of Automation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics","institution_ids":["https://openalex.org/I4210148697"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100623015"],"corresponding_institution_ids":["https://openalex.org/I4210148697","https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":0.3314,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58360357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"3","first_page":"233","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6568057537078857},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6479015350341797},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6423757076263428},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.6134871244430542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5686616897583008},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5277227163314819},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5173156261444092},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.4303993582725525},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.42082715034484863},{"id":"https://openalex.org/keywords/openness-to-experience","display_name":"Openness to experience","score":0.4149847626686096},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.23589271306991577},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16424593329429626},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.07192760705947876}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6568057537078857},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6479015350341797},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6423757076263428},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6134871244430542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5686616897583008},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5277227163314819},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5173156261444092},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.4303993582725525},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42082715034484863},{"id":"https://openalex.org/C84976871","wikidata":"https://www.wikidata.org/wiki/Q2015673","display_name":"Openness to experience","level":2,"score":0.4149847626686096},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.23589271306991577},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16424593329429626},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07192760705947876},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40484-019-0175-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-019-0175-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s40484-019-0175-8","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40484-019-0175-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-019-0175-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s40484-019-0175-8","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.49000000953674316}],"awards":[{"id":"https://openalex.org/G2328377894","display_name":null,"funder_award_id":"61721003","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G353953113","display_name":"\u5927\u6570\u636e\u73af\u5883\u4e0b\u878d\u5408\u591a\u6e90\u4fe1\u606f\u7684\u63a8\u8350\u7cfb\u7edf\u5173\u952e\u95ee\u9898\u7814\u7a76","funder_award_id":"71471016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3743090275","display_name":null,"funder_award_id":"2018YFC0910404","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4476253599","display_name":null,"funder_award_id":"61873141","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4890424949","display_name":"\u79fb\u52a8\u573a\u666f\u4e2d\u7528\u6237\u51fa\u884c\u610f\u56fe\u9884\u6d4b\u4e0e\u5730\u70b9\u63a8\u8350\u7684\u667a\u80fd\u65b9\u6cd5\u7814\u7a76","funder_award_id":"71871019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5814160623","display_name":null,"funder_award_id":"61721003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7489264330","display_name":null,"funder_award_id":"61573207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7618720840","display_name":null,"funder_award_id":"2018YFC0910404","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8108596402","display_name":null,"funder_award_id":"61873141","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966629694.pdf","grobid_xml":"https://content.openalex.org/works/W2966629694.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1979594866","https://openalex.org/W1989277387","https://openalex.org/W2019626736","https://openalex.org/W2020852287","https://openalex.org/W2022174018","https://openalex.org/W2031863757","https://openalex.org/W2038886121","https://openalex.org/W2053168320","https://openalex.org/W2054080205","https://openalex.org/W2063669037","https://openalex.org/W2065579185","https://openalex.org/W2097220641","https://openalex.org/W2097411118","https://openalex.org/W2101856908","https://openalex.org/W2103017472","https://openalex.org/W2105924780","https://openalex.org/W2107575419","https://openalex.org/W2108984616","https://openalex.org/W2112741367","https://openalex.org/W2115137176","https://openalex.org/W2118650392","https://openalex.org/W2125466202","https://openalex.org/W2129795133","https://openalex.org/W2133465414","https://openalex.org/W2134957137","https://openalex.org/W2135993011","https://openalex.org/W2141064505","https://openalex.org/W2142727392","https://openalex.org/W2147805797","https://openalex.org/W2158217645","https://openalex.org/W2170527038","https://openalex.org/W2259938310","https://openalex.org/W2342138444","https://openalex.org/W2621109613","https://openalex.org/W2736280136","https://openalex.org/W2740450751","https://openalex.org/W2765651856","https://openalex.org/W2767826728","https://openalex.org/W2769640811","https://openalex.org/W2950595506","https://openalex.org/W3161977519","https://openalex.org/W4237335579"],"related_works":["https://openalex.org/W2007906249","https://openalex.org/W2908605513","https://openalex.org/W2394242862","https://openalex.org/W2360338400","https://openalex.org/W2361665985","https://openalex.org/W2391461404","https://openalex.org/W2377875154","https://openalex.org/W3198929874","https://openalex.org/W2352558001","https://openalex.org/W2385700214"],"abstract_inverted_index":{"Background":[0],"Transcription":[1,72],"factor":[2,182,213],"is":[3,21,120,133,205,241],"one":[4],"of":[5,18,31,60,71,79,130,167,189,196,223],"the":[6,11,15,28,57,109,142,187,194,211,220,235],"most":[7],"important":[8],"regulators":[9],"in":[10,191],"transcriptional":[12],"process.":[13],"Nevertheless,":[14],"functional":[16,58,136,221],"interpretation":[17,59,192,222],"transcription":[19,49,61,80,181,212],"factors":[20,81],"still":[22],"a":[23,74,88,127,165,206,230],"main":[24],"challenge":[25],"due":[26],"to":[27,34,37,76,92,106,122,198,233],"poor":[29],"performance":[30],"methods":[32,177],"relating":[33],"regulatory":[35,96,147,158,225,236],"regions":[36,97,111,148],"genes.":[38,100,151],"Epigenetic":[39],"information,":[40],"such":[41],"as":[42,135],"chromatin":[43,143],"accessibility,":[44],"contains":[45],"genome\u2010wide":[46],"knowledge":[47],"about":[48],"regulation":[50],"and":[51,98,112,126,149,193,227],"thus":[52,228],"may":[53],"shed":[54],"light":[55],"on":[56,164],"factors.":[62],"Methods":[63],"We":[64,139,184,215],"propose":[65],"EpiFIT":[66,156,163,173,197,204,217],"(Epigenetic":[67],"based":[68],"Functional":[69],"Interpretation":[70],"factors),":[73],"tool":[75,208],"infer":[77],"functions":[78],"from":[82],"ChIP\u2010seq":[83],"data.":[84],"Briefly,":[85],"we":[86,170],"adopt":[87],"variable":[89],"distance":[90],"rule":[91],"establish":[93],"associations":[94,102],"between":[95,146],"nearby":[99],"The":[101,152,239],"are":[103,115],"then":[104],"filtered":[105],"ensure":[107],"that":[108,172],"remaining":[110],"associated":[113,150],"genes":[114,125],"co\u2010open.":[116],"Finally,":[117],"GO":[118,131],"enrichment":[119],"applied":[121],"all":[123],"related":[124],"ranking":[128],"list":[129],"terms":[132],"provided":[134],"interpretation.":[137],"Results":[138],"first":[140],"examined":[141],"openness":[144,190],"correlation":[145,153],"can":[154],"help":[155],"purify":[157],"region\u2013gene":[159],"associations.":[160,202],"By":[161],"evaluating":[162],"set":[166],"real":[168],"data,":[169],"demonstrated":[171],"outperforms":[174],"other":[175,224],"existing":[176],"for":[178,209],"precisely":[179],"interpreting":[180,210],"functions.":[183,214],"further":[185],"verify":[186],"efficiency":[188],"ability":[195],"build":[199],"distal":[200],"region\u2010gene":[201],"Conclusion":[203],"powerful":[207],"believe":[216],"will":[218],"facilitate":[219],"elements,":[226],"open":[229],"new":[231],"door":[232],"understanding":[234],"mechanism.":[237],"Availability":[238],"application":[240],"freely":[242],"accessible":[243],"at":[244],"website:":[245],"bioinfo.au.tsinghua.edu.cn/openness/EpiFIT/":[246],".":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}