{"id":"https://openalex.org/W2905062328","doi":"https://doi.org/10.1007/s40484-018-0163-4","title":"Pharmacodynamics simulation of HOEC by a computational model of arachidonic acid metabolic network","display_name":"Pharmacodynamics simulation of HOEC by a computational model of arachidonic acid metabolic network","publication_year":2018,"publication_date":"2018-12-19","ids":{"openalex":"https://openalex.org/W2905062328","doi":"https://doi.org/10.1007/s40484-018-0163-4","mag":"2905062328"},"language":"en","primary_location":{"id":"doi:10.1007/s40484-018-0163-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-018-0163-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40484-018-0163-4.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007/s40484-018-0163-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028378389","display_name":"Wen Yang","orcid":"https://orcid.org/0000-0002-2202-5941"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen Yang","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397898","display_name":"Xia Wang","orcid":"https://orcid.org/0000-0001-9925-5465"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Wang","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048012256","display_name":"Kenan Li","orcid":"https://orcid.org/0000-0002-4641-6699"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768210","display_name":"State Key Laboratory for Structural Chemistry of Unstable and Stable Species","ror":"https://ror.org/03mw4pt79","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088","https://openalex.org/I4391768210"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kenan Li","raw_affiliation_strings":["<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China"],"affiliations":[{"raw_affiliation_string":"<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","institution_ids":["https://openalex.org/I4210116048","https://openalex.org/I20231570","https://openalex.org/I4391768210"]},{"raw_affiliation_string":"BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083207264","display_name":"Yuanru Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768210","display_name":"State Key Laboratory for Structural Chemistry of Unstable and Stable Species","ror":"https://ror.org/03mw4pt79","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088","https://openalex.org/I4391768210"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanru Liu","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","institution_ids":["https://openalex.org/I4210116048","https://openalex.org/I20231570","https://openalex.org/I4391768210"]},{"raw_affiliation_string":"Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414326","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0002-8131-9384"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I4391768210","display_name":"State Key Laboratory for Structural Chemistry of Unstable and Stable Species","ror":"https://ror.org/03mw4pt79","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088","https://openalex.org/I4391768210"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"<!--2--> BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","institution_ids":["https://openalex.org/I4210116048","https://openalex.org/I20231570","https://openalex.org/I4391768210"]},{"raw_affiliation_string":"BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431408","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0003-3825-3620"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100688144","display_name":"Honglin Li","orcid":"https://orcid.org/0000-0003-2270-1900"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honglin Li","raw_affiliation_strings":["<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5028378389"],"corresponding_institution_ids":["https://openalex.org/I143593769"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.12590217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"30","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"Arachidonic acid","score":0.7923730611801147},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.726902186870575},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"Cyclooxygenase","score":0.6684665679931641},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.6025664210319519},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5870814919471741},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.48733052611351013},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"Lipoxygenase","score":0.4540286362171173},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4280601441860199},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.32289350032806396},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.3222488760948181},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.28107017278671265},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.24245306849479675},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23561248183250427}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7923730611801147},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.726902186870575},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6684665679931641},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6025664210319519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5870814919471741},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.48733052611351013},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.4540286362171173},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4280601441860199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32289350032806396},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3222488760948181},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28107017278671265},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24245306849479675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23561248183250427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40484-018-0163-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-018-0163-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40484-018-0163-4.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40484-018-0163-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-018-0163-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40484-018-0163-4.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1254219105","display_name":null,"funder_award_id":"U1501501","funder_id":"https://openalex.org/F4320336213","funder_display_name":"National Natural Science Foundation of China-Guangdong Joint Fund"},{"id":"https://openalex.org/G1477544716","display_name":null,"funder_award_id":"Guangdong","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1749747779","display_name":null,"funder_award_id":"2016YFA","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2273800250","display_name":null,"funder_award_id":"NSFC-","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2802911279","display_name":null,"funder_award_id":"Young","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4412156213","display_name":null,"funder_award_id":"2016YFA0502304","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5844342392","display_name":null,"funder_award_id":"U1501501","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6058138561","display_name":null,"funder_award_id":", No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G770140775","display_name":null,"funder_award_id":"U1501501","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7879281214","display_name":null,"funder_award_id":"21173076","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8114646031","display_name":null,"funder_award_id":"2016Y","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336213","display_name":"National Natural Science Foundation of China-Guangdong Joint Fund","ror":null},{"id":"https://openalex.org/F4320336648","display_name":"National Program for Support of Top-notch Young Professionals","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2905062328.pdf","grobid_xml":"https://content.openalex.org/works/W2905062328.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W146119624","https://openalex.org/W1504533062","https://openalex.org/W1541709451","https://openalex.org/W1559789667","https://openalex.org/W1573335082","https://openalex.org/W1574721641","https://openalex.org/W1712101512","https://openalex.org/W1833097645","https://openalex.org/W1898350091","https://openalex.org/W1964250764","https://openalex.org/W1964317347","https://openalex.org/W1972134778","https://openalex.org/W1976119105","https://openalex.org/W1978221234","https://openalex.org/W1981581994","https://openalex.org/W1984274895","https://openalex.org/W1984368960","https://openalex.org/W1985459635","https://openalex.org/W1988564036","https://openalex.org/W1991110402","https://openalex.org/W1994659489","https://openalex.org/W1996415000","https://openalex.org/W2002915579","https://openalex.org/W2002926183","https://openalex.org/W2007187686","https://openalex.org/W2010443168","https://openalex.org/W2024176341","https://openalex.org/W2028881470","https://openalex.org/W2029399557","https://openalex.org/W2031445940","https://openalex.org/W2033591223","https://openalex.org/W2041183642","https://openalex.org/W2042065803","https://openalex.org/W2043934481","https://openalex.org/W2048423840","https://openalex.org/W2067674980","https://openalex.org/W2083748640","https://openalex.org/W2083939211","https://openalex.org/W2088302139","https://openalex.org/W2090510390","https://openalex.org/W2093533236","https://openalex.org/W2099589175","https://openalex.org/W2099826569","https://openalex.org/W2102136911","https://openalex.org/W2110107835","https://openalex.org/W2111020654","https://openalex.org/W2135231814","https://openalex.org/W2140239055","https://openalex.org/W2144000913","https://openalex.org/W2152792159","https://openalex.org/W2158293950","https://openalex.org/W2159210732","https://openalex.org/W2160642395","https://openalex.org/W2165191737","https://openalex.org/W2165240999","https://openalex.org/W2165674132","https://openalex.org/W2253420575","https://openalex.org/W2575332383","https://openalex.org/W3023923910","https://openalex.org/W3152480983","https://openalex.org/W4252406065"],"related_works":["https://openalex.org/W4206757259","https://openalex.org/W2071268643","https://openalex.org/W2061702749","https://openalex.org/W1989204823","https://openalex.org/W1990345525","https://openalex.org/W2141308034","https://openalex.org/W2031313177","https://openalex.org/W2077719032","https://openalex.org/W1977981408","https://openalex.org/W1968233993"],"abstract_inverted_index":{"Background":[0],"Arachidonic":[1],"acid":[2],"(AA)":[3],"metabolic":[4,123,133,174],"network":[5,19],"is":[6,243],"activated":[7],"in":[8,52,59,64,104,176,192,200,218],"the":[9,33,80,98,138,145,152,155,159,170,173,177,201,205,215,223,232,246],"most":[10,139],"inflammatory":[11],"related":[12],"diseases,":[13],"and":[14,50,107,166,168,220,226,248],"small\u2010molecular":[15],"drugs":[16,29],"targeting":[17],"AA":[18,101,122,132,224],"are":[20],"increasingly":[21],"available.":[22],"However,":[23,181],"side":[24],"effects":[25,234],"of":[26,47,100,110,120,131,147,162,172,185,188,212,222,235,240],"above":[27],"mentioned":[28],"have":[30],"always":[31],"been":[32],"biggest":[34],"obstacle.":[35],"(+)\u20102\u2010(1\u2010hydroxyl\u20104\u2010oxocyclohexyl)":[36],"ethyl":[37],"caffeate":[38],"(HOEC),":[39],"a":[40,117,128,182],"natural":[41],"product":[42],"acted":[43],"as":[44],"an":[45,92],"inhibitor":[46,237],"5\u2010lipoxygenase":[48],"(5\u2010LOX)":[49],"15\u2010LOX":[51],"vitro":[53],",":[54],"exhibited":[55],"weaker":[56],"therapeutic":[57],"effect":[58,161],"high":[60],"dose":[61,66,142,211],"than":[62],"that":[63,209],"low":[65],"to":[67,78,125,136,151],"collagen":[68],"induced":[69],"arthritis":[70],"(CIA)":[71],"rats.":[72],"In":[73],"this":[74],"study,":[75],"we":[76,90,115,207],"tried":[77],"elucidate":[79],"potential":[81],"regulatory":[82],"mechanism":[83],"by":[84,96,143],"using":[85],"quantitative":[86],"pharmacology.":[87],"Methods":[88],"First,":[89],"generated":[91],"experimental":[93,153],"data":[94,134],"set":[95],"monitoring":[97],"dynamics":[99],"metabolites\u2019":[102],"concentration":[103],"A23187":[105],"stimulated":[106],"different":[108],"doses":[109],"HOEC":[111,163,193,213],"co\u2010incubated":[112],"RAW264.7.":[113],"Then":[114],"constructed":[116],"dynamic":[118],"model":[119,124,156],"A23187\u2010stimulated":[121],"evaluate":[126],"how":[127],"model\u2010based":[129],"simulation":[130],"assists":[135],"find":[137],"suitable":[140],"treatment":[141],"predicting":[144],"pharmacodynamics":[146],"HOEC.":[148],"Results":[149],"Compared":[150],"data,":[154],"could":[157],"simulate":[158],"inhibitory":[160],"on":[164,238],"5\u2010LOX":[165],"15\u2010LOX,":[167],"reproduced":[169],"increase":[171],"flux":[175,216,229],"cyclooxygenase":[178],"(COX)":[179],"pathway.":[180],"concomitant,":[183],"early\u2010stage":[184],"stimulation\u2010related":[186],"decrease":[187],"prostaglandins":[189],"(PGs)":[190],"production":[191],"incubated":[194],"RAW264.7":[195],"cells":[196],"was":[197],"not":[198],"simulated":[199],"model.":[202],"Conclusion":[203],"Using":[204],"model,":[206],"predict":[208],"higher":[210],"disrupts":[214],"balance":[217],"COX":[219,228],"LOX":[221,236],"network,":[225],"increased":[227],"can":[230],"interfere":[231],"curative":[233],"resolution":[239],"inflammation":[241],"which":[242],"crucial":[244],"for":[245],"efficient":[247],"safe":[249],"drug":[250],"design.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}