{"id":"https://openalex.org/W2596544708","doi":"https://doi.org/10.1007/s40484-017-0098-1","title":"SynBioEcoli: a comprehensive metabolism network of engineered <i><b>E. coli</b></i> in three dimensional visualization","display_name":"SynBioEcoli: a comprehensive metabolism network of engineered <i><b>E. coli</b></i> in three dimensional visualization","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2596544708","doi":"https://doi.org/10.1007/s40484-017-0098-1","mag":"2596544708"},"language":"en","primary_location":{"id":"doi:10.1007/s40484-017-0098-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-017-0098-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-017-0098-1.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-017-0098-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102968278","display_name":"Weizhong Tu","orcid":"https://orcid.org/0000-0002-3820-9956"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weizhong Tu","raw_affiliation_strings":["<!--2--> Wuhan LifeSynther Cooperation Limited Wuhan 430078 China","2. Wuhan LifeSynther Cooperation Limited, Wuhan 430078, China"],"affiliations":[{"raw_affiliation_string":"<!--2--> Wuhan LifeSynther Cooperation Limited Wuhan 430078 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"2. Wuhan LifeSynther Cooperation Limited, Wuhan 430078, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167856","display_name":"Shaozhen Ding","orcid":"https://orcid.org/0000-0001-9536-0284"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210139473","display_name":"Tianjin Institute of Industrial Biotechnology","ror":"https://ror.org/042pyga86","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaozhen Ding","raw_affiliation_strings":["<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","institution_ids":["https://openalex.org/I4210139473"]},{"raw_affiliation_string":"1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China","institution_ids":["https://openalex.org/I4210139473","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036405022","display_name":"Ling Wu","orcid":"https://orcid.org/0000-0001-5293-8701"},"institutions":[{"id":"https://openalex.org/I4210139473","display_name":"Tianjin Institute of Industrial Biotechnology","ror":"https://ror.org/042pyga86","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wu","raw_affiliation_strings":["<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","institution_ids":["https://openalex.org/I4210139473"]},{"raw_affiliation_string":"1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China","institution_ids":["https://openalex.org/I4210139473","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101707535","display_name":"Zhe Deng","orcid":"https://orcid.org/0000-0002-6016-9890"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Deng","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050300826","display_name":"Hui Zhu","orcid":"https://orcid.org/0000-0002-8601-669X"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhu","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009496307","display_name":"X. X. Xu","orcid":"https://orcid.org/0009-0000-7080-7107"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotong Xu","raw_affiliation_strings":["<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China"],"affiliations":[{"raw_affiliation_string":"<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443808","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0003-3399-8711"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Lin","raw_affiliation_strings":["<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China"],"affiliations":[{"raw_affiliation_string":"<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069350336","display_name":"Chaonan Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaonan Ye","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021170298","display_name":"Minlu Han","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minlu Han","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692212","display_name":"Mengna Zhao","orcid":"https://orcid.org/0000-0002-9668-8326"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengna Zhao","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446290","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0001-9344-7415"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China"],"affiliations":[{"raw_affiliation_string":"<!--4--> State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"4. State Key Laboratory of Software Engineering and School of Computer Sciences, Wuhan University , Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781054","display_name":"Zixin Deng","orcid":"https://orcid.org/0000-0003-0724-3390"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixin Deng","raw_affiliation_strings":["<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China"],"affiliations":[{"raw_affiliation_string":"<!--3--> Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"3. Ministry of Education, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081624504","display_name":"Junni Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junni Chen","raw_affiliation_strings":["<!--2--> Wuhan LifeSynther Cooperation Limited Wuhan 430078 China","2. Wuhan LifeSynther Cooperation Limited, Wuhan 430078, China"],"affiliations":[{"raw_affiliation_string":"<!--2--> Wuhan LifeSynther Cooperation Limited Wuhan 430078 China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"2. Wuhan LifeSynther Cooperation Limited, Wuhan 430078, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041491902","display_name":"Dong\u2010Qing Wei","orcid":"https://orcid.org/0000-0003-4200-7502"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong\u2010Qing Wei","raw_affiliation_strings":["<!--5--> State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong University Shanghai 200240 China","5. State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China"],"affiliations":[{"raw_affiliation_string":"<!--5--> State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong University Shanghai 200240 China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"5. State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101770220","display_name":"Qian\u2010Nan Hu","orcid":"https://orcid.org/0000-0001-5213-472X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210139473","display_name":"Tianjin Institute of Industrial Biotechnology","ror":"https://ror.org/042pyga86","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian\u2010Nan Hu","raw_affiliation_strings":["<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China"],"affiliations":[{"raw_affiliation_string":"<!--1--> Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China","institution_ids":["https://openalex.org/I4210139473"]},{"raw_affiliation_string":"1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China","institution_ids":["https://openalex.org/I4210139473","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5102968278"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210151591"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02054905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.7544412612915039},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6701611280441284},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.627130925655365},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5150139331817627},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.48643970489501953},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.47748586535453796},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"Cellular metabolism","score":0.44681644439697266},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.44429445266723633},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4388490915298462},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.4106835722923279},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3366529941558838},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2761143147945404},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.23525816202163696},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.1742713749408722},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14322850108146667},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1270270049571991}],"concepts":[{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.7544412612915039},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6701611280441284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.627130925655365},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5150139331817627},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.48643970489501953},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.47748586535453796},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.44681644439697266},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.44429445266723633},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4388490915298462},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.4106835722923279},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3366529941558838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2761143147945404},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.23525816202163696},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.1742713749408722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14322850108146667},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1270270049571991},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40484-017-0098-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-017-0098-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-017-0098-1.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40484-017-0098-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-017-0098-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-017-0098-1.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4790600325","display_name":null,"funder_award_id":"2012CB721000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5532155222","display_name":null,"funder_award_id":"Tianjin","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"},{"id":"https://openalex.org/G5854786607","display_name":null,"funder_award_id":"Tianjin","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6658295785","display_name":null,"funder_award_id":"31270101","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8208342437","display_name":null,"funder_award_id":"1 and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8953631283","display_name":null,"funder_award_id":"31570092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2596544708.pdf","grobid_xml":"https://content.openalex.org/works/W2596544708.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W75747240","https://openalex.org/W1971471239","https://openalex.org/W1977186514","https://openalex.org/W2015292449","https://openalex.org/W2024038403","https://openalex.org/W2029195137","https://openalex.org/W2067916064","https://openalex.org/W2068526246","https://openalex.org/W2083011190","https://openalex.org/W2087064593","https://openalex.org/W2103612757","https://openalex.org/W2108859156","https://openalex.org/W2120167281","https://openalex.org/W2122306708","https://openalex.org/W2126175129","https://openalex.org/W2128329041","https://openalex.org/W2131848047","https://openalex.org/W2135435176","https://openalex.org/W2140239055","https://openalex.org/W2144885342","https://openalex.org/W2167482691","https://openalex.org/W2168465568","https://openalex.org/W2170427655","https://openalex.org/W2181121096","https://openalex.org/W3103786587","https://openalex.org/W4248500926"],"related_works":["https://openalex.org/W3047447888","https://openalex.org/W2053717739","https://openalex.org/W2626617466","https://openalex.org/W1999457307","https://openalex.org/W2126646394","https://openalex.org/W2338895903","https://openalex.org/W3044523069","https://openalex.org/W1975098623","https://openalex.org/W1989168955","https://openalex.org/W2094399313"],"abstract_inverted_index":{"Background":[0],"A":[1],"comprehensive":[2,86,132],"metabolism":[3,107,144],"network":[4,88,145],"of":[5,33,44,55,69,79,113,134],"engineered":[6,70,114,135],"E.":[7,71,115,136],"coli":[8,72,116,137],"is":[9],"very":[10],"important":[11],"in":[12,27],"systems":[13],"biology":[14],"and":[15,46,61,73,138],"metabolomics":[16],"studies.":[17],"Many":[18],"tools":[19],"focus":[20],"on":[21],"two\u2010dimensional":[22],"space":[23],"to":[24,38,83],"display":[25],"pathways":[26],"metabolic":[28,45,87,98],"network.":[29],"However,":[30],"the":[31,41,140],"usage":[32],"three\u2010dimensional":[34],"visualization":[35,82,146],"may":[36],"help":[37],"understand":[39],"better":[40],"intricate":[42],"topology":[43],"regulatory":[47],"networks.":[48],"Methods":[49],"We":[50],"manually":[51],"curated":[52,103],"large":[53],"amount":[54],"experimental":[56],"data":[57],"(including":[58],"pathways,":[59,96],"reactions":[60],"metabolites)":[62],"from":[63,104],"literature":[64],"related":[65,109],"with":[66,110,121],"different":[67,111],"types":[68,112],"then":[74],"utilized":[75],"a":[76,85,131],"novel":[77],"technology":[78],"three":[80],"dimensional":[81],"develop":[84],"named":[89],"SynBioEcoli.":[90],"Results":[91],"SynBioEoli":[92],"contains":[93],"740":[94],"biosynthetic":[95],"3,889":[97],"reactions,":[99],"2,255":[100],"chemical":[101],"compoundsmanually":[102],"about":[105],"11,000":[106],"publications":[108],".":[117,163],"Furthermore,":[118],"SynBioEcoli":[119,126],"integrates":[120],"various":[122],"informatics":[123],"techniques.":[124],"Conclusions":[125],"could":[127,149],"be":[128,150],"regarded":[129],"as":[130,156],"knowledgebase":[133],"represents":[139],"next":[141],"generation":[142],"cellular":[143],"technology.":[147],"It":[148],"accessed":[151],"via":[152],"web":[153],"browsers":[154],"(such":[155],"Google":[157],"Chrome)":[158],"supporting":[159],"WebGL,":[160],"at":[161],"http://www.rxnfinder.org/synbioecoli/":[162]},"counts_by_year":[],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}