{"id":"https://openalex.org/W2141218053","doi":"https://doi.org/10.1007/s40484-013-0018-y","title":"Structure\u2010based protein\u2010protein interaction networks and drug design","display_name":"Structure\u2010based protein\u2010protein interaction networks and drug design","publication_year":2013,"publication_date":"2013-08-31","ids":{"openalex":"https://openalex.org/W2141218053","doi":"https://doi.org/10.1007/s40484-013-0018-y","mag":"2141218053"},"language":"en","primary_location":{"id":"doi:10.1007/s40484-013-0018-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-013-0018-y","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-013-0018-y.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-013-0018-y.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074736458","display_name":"Hammad Naveed","orcid":"https://orcid.org/0000-0002-1867-974X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hammad Naveed","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences\u2010Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences\u2010Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China","institution_ids":["https://openalex.org/I4210106477","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103171811","display_name":"Jing\u2010Dong J. Han","orcid":"https://orcid.org/0000-0002-9270-7139"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingdong J. Han","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences\u2010Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences\u2010Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China","institution_ids":["https://openalex.org/I4210106477","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4898,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83728148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1","issue":"3","first_page":"183","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.620078980922699},{"id":"https://openalex.org/keywords/protein-interaction-networks","display_name":"Protein Interaction Networks","score":0.5795047283172607},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5311160087585449},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.46320995688438416},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.46189936995506287},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.4342879056930542},{"id":"https://openalex.org/keywords/network-structure","display_name":"Network structure","score":0.4135099947452545},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4129973351955414},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.41131776571273804},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38450220227241516},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.21417880058288574},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.16507327556610107},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12234815955162048},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.08643123507499695}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.620078980922699},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.5795047283172607},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5311160087585449},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.46320995688438416},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.46189936995506287},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.4342879056930542},{"id":"https://openalex.org/C2988224531","wikidata":"https://www.wikidata.org/wiki/Q20830730","display_name":"Network structure","level":2,"score":0.4135099947452545},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4129973351955414},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41131776571273804},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38450220227241516},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21417880058288574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16507327556610107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12234815955162048},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08643123507499695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40484-013-0018-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-013-0018-y","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-013-0018-y.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40484-013-0018-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40484-013-0018-y","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40484-013-0018-y.pdf","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2679769599","display_name":null,"funder_award_id":"31210103916","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G273771910","display_name":null,"funder_award_id":"# 2012Y1SB0006","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4258171007","display_name":null,"funder_award_id":"#2011CB504206","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G4388386524","display_name":null,"funder_award_id":"#31210103916","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4485922584","display_name":null,"funder_award_id":"KSCX2-EW-R-02","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4495847969","display_name":null,"funder_award_id":"KSCX2-EW-J-15","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4853103681","display_name":null,"funder_award_id":"#KSCX2\u2010EW\u2010R\u201002","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G615871638","display_name":"\u6052\u6cb3\u7334\u4e0e\u4eba\u7c7b\u5927\u8111\u8870\u8001\u8fc7\u7a0b\u4e2d\u7ec4\u86cb\u767d\u4fee\u9970\u5bf9\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7f51\u7edc\u7684\u53d1\u73b0\u4e0e\u6bd4\u8f83","funder_award_id":"91019019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8024315181","display_name":null,"funder_award_id":"XDA01010303","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G8322228019","display_name":null,"funder_award_id":"2011CB504206","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G8712589862","display_name":null,"funder_award_id":"KSCX2\u2010EW\u2010J\u201015","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141218053.pdf","grobid_xml":"https://content.openalex.org/works/W2141218053.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W1480355062","https://openalex.org/W1491036646","https://openalex.org/W1500036797","https://openalex.org/W1517566065","https://openalex.org/W1544009106","https://openalex.org/W1565314983","https://openalex.org/W1644749979","https://openalex.org/W1774748215","https://openalex.org/W1965378795","https://openalex.org/W1969436326","https://openalex.org/W1970008650","https://openalex.org/W1975121208","https://openalex.org/W1980177098","https://openalex.org/W1982717626","https://openalex.org/W1985226185","https://openalex.org/W1986308863","https://openalex.org/W1986930831","https://openalex.org/W1989684700","https://openalex.org/W1991392283","https://openalex.org/W1992578437","https://openalex.org/W1993490021","https://openalex.org/W1994803330","https://openalex.org/W1998767819","https://openalex.org/W2000691433","https://openalex.org/W2003516452","https://openalex.org/W2006281337","https://openalex.org/W2009081245","https://openalex.org/W2009495978","https://openalex.org/W2010240982","https://openalex.org/W2012219352","https://openalex.org/W2012852001","https://openalex.org/W2015707695","https://openalex.org/W2017522347","https://openalex.org/W2018934112","https://openalex.org/W2019543926","https://openalex.org/W2019691413","https://openalex.org/W2019974881","https://openalex.org/W2021904716","https://openalex.org/W2022196194","https://openalex.org/W2023170820","https://openalex.org/W2024985940","https://openalex.org/W2027970979","https://openalex.org/W2028820256","https://openalex.org/W2031880498","https://openalex.org/W2032694615","https://openalex.org/W2036654348","https://openalex.org/W2039473152","https://openalex.org/W2039781075","https://openalex.org/W2040865917","https://openalex.org/W2045098692","https://openalex.org/W2047693963","https://openalex.org/W2050721857","https://openalex.org/W2053538195","https://openalex.org/W2056490499","https://openalex.org/W2058463742","https://openalex.org/W2058813547","https://openalex.org/W2059446387","https://openalex.org/W2062941476","https://openalex.org/W2064959704","https://openalex.org/W2065304353","https://openalex.org/W2065540447","https://openalex.org/W2066672837","https://openalex.org/W2070217906","https://openalex.org/W2070789802","https://openalex.org/W2070854001","https://openalex.org/W2073587387","https://openalex.org/W2074370114","https://openalex.org/W2077776336","https://openalex.org/W2077997913","https://openalex.org/W2078644058","https://openalex.org/W2078803528","https://openalex.org/W2083045667","https://openalex.org/W2083978969","https://openalex.org/W2091710329","https://openalex.org/W2093400327","https://openalex.org/W2095867585","https://openalex.org/W2098223336","https://openalex.org/W2098656855","https://openalex.org/W2100025044","https://openalex.org/W2102312699","https://openalex.org/W2102839822","https://openalex.org/W2103675811","https://openalex.org/W2104245599","https://openalex.org/W2109604654","https://openalex.org/W2110699703","https://openalex.org/W2112947018","https://openalex.org/W2113019448","https://openalex.org/W2114445615","https://openalex.org/W2116117181","https://openalex.org/W2116603180","https://openalex.org/W2121175754","https://openalex.org/W2122863289","https://openalex.org/W2124463526","https://openalex.org/W2125013516","https://openalex.org/W2125828540","https://openalex.org/W2126760155","https://openalex.org/W2127761209","https://openalex.org/W2128601422","https://openalex.org/W2128888818","https://openalex.org/W2130479394","https://openalex.org/W2130494178","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2132160618","https://openalex.org/W2133591516","https://openalex.org/W2133712572","https://openalex.org/W2134691130","https://openalex.org/W2136479434","https://openalex.org/W2140463009","https://openalex.org/W2141374568","https://openalex.org/W2143549808","https://openalex.org/W2144885342","https://openalex.org/W2145321215","https://openalex.org/W2150065588","https://openalex.org/W2151460035","https://openalex.org/W2152444476","https://openalex.org/W2153624566","https://openalex.org/W2154896031","https://openalex.org/W2155157373","https://openalex.org/W2156779720","https://openalex.org/W2158467294","https://openalex.org/W2158676715","https://openalex.org/W2162128823","https://openalex.org/W2164079357","https://openalex.org/W2165253681","https://openalex.org/W2167869241","https://openalex.org/W2168264491","https://openalex.org/W2170806980","https://openalex.org/W2171249995","https://openalex.org/W2259938310","https://openalex.org/W2315255289","https://openalex.org/W2407395233","https://openalex.org/W2516489619","https://openalex.org/W2519244818","https://openalex.org/W2915108429","https://openalex.org/W2917939076","https://openalex.org/W3103786587","https://openalex.org/W4233060585","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W1987705964","https://openalex.org/W1841073402","https://openalex.org/W4377086792","https://openalex.org/W2414873431","https://openalex.org/W2949751838","https://openalex.org/W2145100112","https://openalex.org/W2137238644","https://openalex.org/W4384303460"],"abstract_inverted_index":{"Proteins":[0],"carry":[1],"out":[2],"their":[3],"functions":[4],"by":[5],"interacting":[6],"with":[7,98],"other":[8],"proteins":[9],"and":[10,43,70],"small":[11],"molecules,":[12],"forming":[13],"a":[14,99],"complex":[15],"interaction":[16,29,68,93],"network.":[17],"In":[18],"this":[19],"review,":[20],"we":[21],"briefly":[22],"introduce":[23],"classical":[24],"graph":[25,60],"theory":[26,61],"based":[27,62,66,91],"protein\u2010protein":[28,67,92],"networks.":[30,52],"We":[31,53,84],"also":[32],"describe":[33],"the":[34,44,56,71,74,77,87],"commonly":[35],"used":[36],"experimental":[37],"methods":[38],"to":[39,64],"construct":[40],"these":[41,51],"networks,":[42],"insights":[45],"that":[46],"can":[47],"be":[48],"gained":[49],"from":[50,59],"then":[54],"discuss":[55,86],"recent":[57],"transition":[58],"networks":[63,69,81,94],"structure":[65,90],"advantages":[72],"of":[73,89],"latter":[75],"over":[76],"former,":[78],"using":[79],"two":[80],"as":[82],"examples.":[83],"further":[85],"usefulness":[88],"for":[95],"drug":[96,103],"discovery,":[97],"special":[100],"emphasis":[101],"on":[102],"repositioning.":[104]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-06-23T13:55:30.953635","created_date":"2025-10-10T00:00:00"}
