{"id":"https://openalex.org/W4416253333","doi":"https://doi.org/10.1007/s13755-025-00385-z","title":"Disulfidptosis-associated gene signatures in sepsis: a diagnostic model based on an LLM-assisted bioinformatics analysis","display_name":"Disulfidptosis-associated gene signatures in sepsis: a diagnostic model based on an LLM-assisted bioinformatics analysis","publication_year":2025,"publication_date":"2025-11-15","ids":{"openalex":"https://openalex.org/W4416253333","doi":"https://doi.org/10.1007/s13755-025-00385-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41246143"},"language":"en","primary_location":{"id":"doi:10.1007/s13755-025-00385-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-025-00385-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s13755-025-00385-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026480489","display_name":"Tian Liu","orcid":"https://orcid.org/0000-0002-6437-8892"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Liu","raw_affiliation_strings":["Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100960044","display_name":"Zhi Mao","orcid":"https://orcid.org/0000-0001-6168-8732"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Mao","raw_affiliation_strings":["Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China","Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032799121","display_name":"Jiake Chai","orcid":"https://orcid.org/0000-0003-4692-3196"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiake Chai","raw_affiliation_strings":["Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Senior Department of Burns & Plastic Surgery, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100656654","display_name":"Hui Zhou","orcid":"https://orcid.org/0000-0001-8739-963X"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhou","raw_affiliation_strings":["Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China","Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002592816","display_name":"Yirui Qu","orcid":"https://orcid.org/0000-0001-8529-1473"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yirui Qu","raw_affiliation_strings":["Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100548178","display_name":"Chengfeng Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengfeng Xu","raw_affiliation_strings":["Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006896932","display_name":"Yunfei Chi","orcid":"https://orcid.org/0000-0002-2997-6555"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunfei Chi","raw_affiliation_strings":["Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China"],"raw_orcid":"https://orcid.org/0000-0002-2997-6555","affiliations":[{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048 China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Outpatient, The Fourth Medical Center of PLA General Hospital, 51 Fucheng Road, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006896932","https://openalex.org/A5032799121"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":{"value":2790,"currency":"EUR","value_usd":3590},"apc_paid":{"value":2790,"currency":"EUR","value_usd":3590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32533911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3873000144958496},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.2800000011920929},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.2700999975204468},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.2687000036239624},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.26669999957084656}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5346999764442444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5149000287055969},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3873000144958496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3573000133037567},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3425999879837036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3409999907016754},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3287000060081482},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2700999975204468},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13755-025-00385-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-025-00385-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},{"id":"pmid:41246143","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41246143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health information science and systems","raw_type":null},{"id":"pmh:oai:europepmc.org:11426833","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12618752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13755-025-00385-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-025-00385-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1788396114","https://openalex.org/W2280404143","https://openalex.org/W2795549750","https://openalex.org/W2965641704","https://openalex.org/W2998853022","https://openalex.org/W3013936205","https://openalex.org/W3161976706","https://openalex.org/W3214507383","https://openalex.org/W4212938842","https://openalex.org/W4214849883","https://openalex.org/W4296834481","https://openalex.org/W4304185482","https://openalex.org/W4319310752","https://openalex.org/W4321178799","https://openalex.org/W4367059833","https://openalex.org/W4377292543","https://openalex.org/W4378905932","https://openalex.org/W4385782388","https://openalex.org/W4385872156","https://openalex.org/W4388793630","https://openalex.org/W4391581642","https://openalex.org/W4399728546","https://openalex.org/W4400745325","https://openalex.org/W4401947838","https://openalex.org/W4403420208","https://openalex.org/W4408226143"],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1,208],"investigated":[2],"the":[3,8,76,120,154,159,164,199,240],"involvement":[4],"of":[5,10,43,100,104,123,195,244],"disulfidptosis":[6,222],"in":[7,92,135,198,223],"pathophysiology":[9],"sepsis":[11,141,200],"by":[12,18],"applying":[13],"a":[14,31,62,93,218],"bioinformatics":[15,55,64,111,114,210],"analysis":[16,211],"assisted":[17,209],"large":[19,213],"language":[20,214],"models":[21,157,215],"(LLMs).":[22],"Based":[23,137],"on":[24,119,138],"DeepSeek":[25,58],"R1":[26],"and":[27,50,88,96,182,216,231,242],"retrieval-augmented":[28],"generation":[29],"technology,":[30],"deep":[32],"retrieval":[33],"architecture":[34],"was":[35,52,90,229],"developed":[36],"for":[37,54,110,221,239],"extracting":[38],"disulfidptosis-related":[39,106,128],"genes.":[40],"An":[41],"intersection":[42],"genes":[44,107,131,197,233],"from":[45,66],"LLM":[46,121],"extraction,":[47,49],"manual":[48],"datasets":[51],"included":[53,109],"analyses.":[56,112],"Using":[57],"R1,":[59],"we":[60],"synthesized":[61],"multi-step":[63],"protocol":[65],"prior":[67],"publications.":[68],"The":[69],"analyses":[70],"were":[71,81,108,116,133,143,234],"then":[72],"performed":[73,91],"according":[74],"to":[75],"protocol.":[77],"Key":[78],"gene":[79],"candidates":[80],"identified":[82,134],"using":[83],"multiple":[84],"machine":[85,155,162],"learning":[86,156],"models,":[87],"validation":[89,190],"cecal":[94],"ligation":[95],"puncture":[97],"mouse":[98],"model":[99,228],"sepsis.":[101,136,224,245],"A":[102,225],"total":[103],"21":[105],"Nine":[113],"techniques":[115],"integrated":[117],"based":[118],"summarization":[122],"two":[124,146],"key":[125,187],"references.":[126],"Thirteen":[127],"differentially":[129],"expressed":[130],"(DEGs)":[132],"these":[139,196],"DEGs,":[140],"patients":[142],"classified":[144],"into":[145],"molecular":[147],"subgroups":[148],"with":[149,203,212],"distinct":[150],"immune":[151],"profiles.":[152],"Among":[153],"evaluated,":[158],"support":[160],"vector":[161],"achieved":[163],"highest":[165],"classification":[166],"performance":[167],"(AUC":[168],"=":[169],"0.989).":[170],"Five":[171],"hub":[172],"genes\u2014":[173],"FSTL1":[174],",":[175,177,179,181],"SELP":[176],"PPBP":[178],"ITGA2B":[180],"PF4":[183],"\u2014were":[184],"selected":[185],"as":[186,236],"biomarkers.":[188],"Experimental":[189],"confirmed":[191],"significantly":[192],"elevated":[193],"expression":[194],"mice":[201],"compared":[202],"their":[204],"sham":[205],"counterparts.":[206],"Our":[207],"revealed":[217],"critical":[219],"role":[220],"high-performance":[226],"diagnostic":[227],"developed,":[230],"five":[232],"validated":[235],"potential":[237],"biomarkers":[238],"diagnosis":[241],"treatment":[243]},"counts_by_year":[],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-11-15T00:00:00"}
