{"id":"https://openalex.org/W4392921933","doi":"https://doi.org/10.1007/s13755-024-00275-w","title":"Alterations of DNA methylation profile in peripheral blood of children with simple obesity","display_name":"Alterations of DNA methylation profile in peripheral blood of children with simple obesity","publication_year":2024,"publication_date":"2024-03-18","ids":{"openalex":"https://openalex.org/W4392921933","doi":"https://doi.org/10.1007/s13755-024-00275-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/38505098"},"language":"en","primary_location":{"id":"doi:10.1007/s13755-024-00275-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-024-00275-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13755-024-00275-w.pdf","source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13755-024-00275-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101331813","display_name":"Yi Ren","orcid":"https://orcid.org/0000-0002-3076-0268"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210086862","display_name":"Hainan Maternal and Child Health Hospital","ror":"https://ror.org/000aph098","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086862"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Ren","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, Haikou Maternal and Child Health Hospital, Haikou, 570100 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, Haikou Maternal and Child Health Hospital, Haikou, 570100 China","institution_ids":["https://openalex.org/I4210086862"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082079852","display_name":"Peng Huang","orcid":"https://orcid.org/0000-0003-3011-3359"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Huang","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721854","display_name":"Xiaoyan Huang","orcid":"https://orcid.org/0000-0001-6306-6080"},"institutions":[{"id":"https://openalex.org/I4210109801","display_name":"Hainan Modern Women and Children's Hospital","ror":"https://ror.org/01x48j266","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Huang","raw_affiliation_strings":["Department of Genetics, Metabolism, and Endocrinology, Hainan Women and Children's Medical Center, Haikou, 570100 China","Department of Genetics, Metabolism, and Endocrinology, Hainan Women and Children's Medical Center, Haikou, 570100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Metabolism, and Endocrinology, Hainan Women and Children's Medical Center, Haikou, 570100 China","institution_ids":["https://openalex.org/I4210109801"]},{"raw_affiliation_string":"Department of Genetics, Metabolism, and Endocrinology, Hainan Women and Children's Medical Center, Haikou, 570100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388624","display_name":"Lu Zhang","orcid":"https://orcid.org/0000-0002-2794-7371"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Zhang","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110710776","display_name":"Lingjuan Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingjuan Liu","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389005","display_name":"Wei Xiang","orcid":"https://orcid.org/0000-0002-0608-065X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjuan Liu","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Hainan Women and Children's Medical Center, Haikou, 570100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hainan Women and Children's Medical Center, Haikou, 570100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389005","display_name":"Wei Xiang","orcid":"https://orcid.org/0000-0002-0608-065X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210109801","display_name":"Hainan Modern Women and Children's Hospital","ror":"https://ror.org/01x48j266","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109801"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Xiang","raw_affiliation_strings":["Children's Hospital of Fudan University at Hainan, Haikou, 570100 China","Children's Hospital of Hainan Medical University, Haikou, 570100 China","Hainan Women and Children's Medical Center, Haikou, 570100 China","Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Fudan University at Hainan, Haikou, 570100 China","institution_ids":["https://openalex.org/I4210159329"]},{"raw_affiliation_string":"Children's Hospital of Hainan Medical University, Haikou, 570100 China","institution_ids":["https://openalex.org/I79731167"]},{"raw_affiliation_string":"Hainan Women and Children's Medical Center, Haikou, 570100 China","institution_ids":["https://openalex.org/I4210109801","https://openalex.org/I79731167"]},{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768814","display_name":"Xiaojie He","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liqun Liu","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681606","display_name":"Liqun Liu","orcid":"https://orcid.org/0000-0003-1530-9775"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210104793","display_name":"Second People Hospital of Hunan","ror":"https://ror.org/01eda7a75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104793"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liqun Liu","raw_affiliation_strings":["Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I4210104793","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100768814","display_name":"Xiaojie He","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaojie He","raw_affiliation_strings":["Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","Laboratory of Pediatric Nephrology, Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Laboratory of Pediatric Nephrology, Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, 410011 China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100389005","https://openalex.org/A5100768814","https://openalex.org/A5110710776"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210104793","https://openalex.org/I4210109801","https://openalex.org/I4210153856","https://openalex.org/I4210159329","https://openalex.org/I79731167"],"apc_list":{"value":2790,"currency":"EUR","value_usd":3590},"apc_paid":{"value":2790,"currency":"EUR","value_usd":3590},"fwci":2.317,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.88646664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.83714759349823},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.7922497391700745},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.7749987244606018},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5394248962402344},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.4929506778717041},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"Childhood obesity","score":0.4122142493724823},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4120649993419647},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40771520137786865},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.35898375511169434},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3257477879524231},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.31241875886917114},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23034781217575073},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19873258471488953}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.83714759349823},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7922497391700745},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7749987244606018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5394248962402344},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.4929506778717041},{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.4122142493724823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4120649993419647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40771520137786865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35898375511169434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3257477879524231},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.31241875886917114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23034781217575073},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19873258471488953},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13755-024-00275-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-024-00275-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13755-024-00275-w.pdf","source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},{"id":"pmid:38505098","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38505098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health information science and systems","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10948706","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10948706","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10948706/pdf/13755_2024_Article_275.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Health Inf Sci Syst","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13755-024-00275-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13755-024-00275-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13755-024-00275-w.pdf","source":{"id":"https://openalex.org/S4210178793","display_name":"Health Information Science and Systems","issn_l":"2047-2501","issn":["2047-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Information Science and Systems","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G4359668061","display_name":null,"funder_award_id":"No.2023SK4018","funder_id":"https://openalex.org/F4320330206","funder_display_name":"Science and Technology Program of Hunan Province"},{"id":"https://openalex.org/G5213266309","display_name":null,"funder_award_id":"No.820MS168","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G6828649603","display_name":null,"funder_award_id":"No.ZDYF2021SHFZ226","funder_id":"https://openalex.org/F6806810831","funder_display_name":"Hainan Provincial Key Laboratory of Food Nutrition and Functional Foods"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327827","display_name":"Key Research and Development Project of Hainan Province","ror":null},{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null},{"id":"https://openalex.org/F6806810831","display_name":"Hainan Provincial Key Laboratory of Food Nutrition and Functional Foods","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392921933.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W154753542","https://openalex.org/W1984063697","https://openalex.org/W1998979801","https://openalex.org/W2025342750","https://openalex.org/W2027839715","https://openalex.org/W2055986128","https://openalex.org/W2060319981","https://openalex.org/W2079597091","https://openalex.org/W2086165790","https://openalex.org/W2099786709","https://openalex.org/W2101675838","https://openalex.org/W2101688816","https://openalex.org/W2104651942","https://openalex.org/W2118397007","https://openalex.org/W2153383900","https://openalex.org/W2520681117","https://openalex.org/W2606989374","https://openalex.org/W2766179063","https://openalex.org/W2795757307","https://openalex.org/W2854518343","https://openalex.org/W2895759289","https://openalex.org/W2944967886","https://openalex.org/W3023759921","https://openalex.org/W3044824513","https://openalex.org/W3085613399","https://openalex.org/W3088719324","https://openalex.org/W3109831279","https://openalex.org/W3120875453","https://openalex.org/W3130442546","https://openalex.org/W3202787968","https://openalex.org/W4214858852","https://openalex.org/W4221044397","https://openalex.org/W4225787402","https://openalex.org/W4229014665"],"related_works":["https://openalex.org/W2902329290","https://openalex.org/W2169344098","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W4233664389","https://openalex.org/W2107880877","https://openalex.org/W2151182744","https://openalex.org/W4286742095","https://openalex.org/W2150651400"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"To":[2],"investigate":[3],"the":[4,55,62,81,92,107,149,176],"association":[5],"between":[6,94],"DNA":[7,17,103,193],"methylation":[8,18,104,177,194,204],"and":[9,31,70,97,158,172,188,207],"childhood":[10,199,215],"simple":[11,29,200,216],"obesity.":[12,201,217],"Methods":[13],"Genome-wide":[14],"analysis":[15,44,79,90,125],"of":[16,45,65,84,118,179,205],"was":[19,50,110],"conducted":[20],"on":[21,59],"peripheral":[22],"blood":[23],"samples":[24],"from":[25],"41":[26],"children":[27],"with":[28,183],"obesity":[30,108],"31":[32],"normal":[33],"controls":[34],"to":[35,198],"identify":[36],"differentially":[37,46],"methylated":[38,47,63],"sites":[39],"(DMS).":[40],"Subsequently,":[41],"gene":[42],"functional":[43],"genes":[48,150],"(DMGs)":[49],"carried":[51],"out.":[52],"After":[53],"screening":[54],"characteristic":[56,76,146],"DMGs":[57,128],"based":[58],"specific":[60,95],"conditions,":[61],"levels":[64],"these":[66],"DMS":[67,96,120,147],"were":[68,121,129,168],"evaluated":[69],"verified":[71],"by":[72],"pyrosequencing.":[73],"Receiver":[74],"operating":[75],"(ROC)":[77],"curve":[78],"assessed":[80],"predictive":[82],"efficacy":[83],"corresponding":[85],"DMGs.":[86],"Finally,":[87],"Pearson":[88],"correlation":[89,93],"revealed":[91,126],"clinical":[98],"data.":[99],"Results":[100],"The":[101,145,202],"overall":[102],"level":[105,178],"in":[106,114,132],"group":[109],"significantly":[111,181],"lower":[112],"than":[113],"normal.":[115],"A":[116,153],"total":[117],"241":[119],"identified.":[122],"Functional":[123],"pathway":[124],"that":[127],"primarily":[130],"involved":[131],"lipid":[133],"metabolism,":[134,136,139],"carbohydrate":[135],"amino":[137],"acid":[138],"human":[140],"diseases,":[141],"among":[142],"other":[143],"pathways.":[144],"within":[148],"Transcription":[151],"factor":[152],"mitochondrial":[154],"(":[155],"TFAM":[156],")":[157,167],"Piezo":[159],"type":[160],"mechanosensitive":[161],"ion":[162],"channel":[163],"component":[164],"1(":[165],"PIEZO1":[166],"recognized":[169],"as":[170,212],"CpG-cg05831083":[171,180,206],"CpG-cg14926485,":[173],"respectively.":[174],"Furthermore,":[175],"correlated":[182],"body":[184],"mass":[185],"index":[186],"(BMI)":[187],"vitamin":[189],"D.":[190],"Conclusions":[191],"Abnormal":[192],"is":[195],"closely":[196],"related":[197],"altered":[203],"CpG-cg14926485":[208],"could":[209],"potentially":[210],"serve":[211],"biomarkers":[213],"for":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2025-10-10T00:00:00"}
