{"id":"https://openalex.org/W4400098546","doi":"https://doi.org/10.1007/s13721-024-00444-7","title":"Network pharmacology and experimental validation to explore the anti-aging mechanism of action of betulinic acid","display_name":"Network pharmacology and experimental validation to explore the anti-aging mechanism of action of betulinic acid","publication_year":2024,"publication_date":"2024-06-27","ids":{"openalex":"https://openalex.org/W4400098546","doi":"https://doi.org/10.1007/s13721-024-00444-7"},"language":"en","primary_location":{"id":"doi:10.1007/s13721-024-00444-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13721-024-00444-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210178532","display_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","issn_l":"2192-6662","issn":["2192-6662","2192-6670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367988","display_name":"Haiyan Chen","orcid":"https://orcid.org/0000-0002-9312-7320"},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]},{"id":"https://openalex.org/I49232843","display_name":"Changchun University","ror":"https://ror.org/02an57k10","country_code":"CN","type":"education","lineage":["https://openalex.org/I49232843"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyan Chen","raw_affiliation_strings":["College of Life Sciences, Changchun Sci-Tech University, Changchun, 130600, Jilin, China","College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China"],"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Changchun Sci-Tech University, Changchun, 130600, Jilin, China","institution_ids":["https://openalex.org/I49232843"]},{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100316862","display_name":"Rongji Li","orcid":null},"institutions":[{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongji Li","raw_affiliation_strings":["College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China"],"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China","institution_ids":["https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025100393","display_name":"Xinqi Ma","orcid":"https://orcid.org/0000-0003-4345-2421"},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinqi Ma","raw_affiliation_strings":["Agricultural College, Yanbian University, Yanbian, 133002, China"],"affiliations":[{"raw_affiliation_string":"Agricultural College, Yanbian University, Yanbian, 133002, China","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047968222","display_name":"Zhidong Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhidong Qiu","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101886709","display_name":"Ye Qiu","orcid":"https://orcid.org/0000-0001-9182-1952"},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Qiu","raw_affiliation_strings":["College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130118, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100367988"],"corresponding_institution_ids":["https://openalex.org/I4210128075","https://openalex.org/I49232843"],"apc_list":{"value":2390,"currency":"EUR","value_usd":2990},"apc_paid":null,"fwci":0.7288,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69927407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"13","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betulinic-acid","display_name":"Betulinic acid","score":0.9387359619140625},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5620321035385132},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.49628859758377075},{"id":"https://openalex.org/keywords/action","display_name":"Action (physics)","score":0.4813700318336487},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43098771572113037},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3877584934234619},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36463814973831177},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3021358251571655},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16933101415634155},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.08544015884399414},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.06607836484909058}],"concepts":[{"id":"https://openalex.org/C2777829905","wikidata":"https://www.wikidata.org/wiki/Q384111","display_name":"Betulinic acid","level":2,"score":0.9387359619140625},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5620321035385132},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.49628859758377075},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.4813700318336487},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43098771572113037},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3877584934234619},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36463814973831177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3021358251571655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16933101415634155},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.08544015884399414},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.06607836484909058},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s13721-024-00444-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13721-024-00444-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210178532","display_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","issn_l":"2192-6662","issn":["2192-6662","2192-6670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5299999713897705}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1764303255","https://openalex.org/W1967331757","https://openalex.org/W1970213932","https://openalex.org/W2011956986","https://openalex.org/W2033591223","https://openalex.org/W2041633241","https://openalex.org/W2070944104","https://openalex.org/W2096130774","https://openalex.org/W2108473200","https://openalex.org/W2126525177","https://openalex.org/W2167584365","https://openalex.org/W2188278071","https://openalex.org/W2288482594","https://openalex.org/W2311745508","https://openalex.org/W2347012456","https://openalex.org/W2415173052","https://openalex.org/W2422981416","https://openalex.org/W2494835903","https://openalex.org/W2554932040","https://openalex.org/W2581564586","https://openalex.org/W2618264839","https://openalex.org/W2774506962","https://openalex.org/W2795890496","https://openalex.org/W2901280112","https://openalex.org/W2901502060","https://openalex.org/W2941224845","https://openalex.org/W2942936579","https://openalex.org/W2943433660","https://openalex.org/W2967225670","https://openalex.org/W2967637185","https://openalex.org/W2976530897","https://openalex.org/W2982137333","https://openalex.org/W2982598963","https://openalex.org/W2995486346","https://openalex.org/W2998457986","https://openalex.org/W3010215457","https://openalex.org/W3029220716","https://openalex.org/W3036199760","https://openalex.org/W3085905016","https://openalex.org/W3093863779","https://openalex.org/W3094279071","https://openalex.org/W3099230550","https://openalex.org/W3111004300","https://openalex.org/W3122489173","https://openalex.org/W3138817522","https://openalex.org/W3142485208","https://openalex.org/W3154191893","https://openalex.org/W3168097989","https://openalex.org/W3172040299","https://openalex.org/W3197359319","https://openalex.org/W4213157453","https://openalex.org/W4225165250","https://openalex.org/W4243898144","https://openalex.org/W4285178043","https://openalex.org/W4288084900","https://openalex.org/W4288514574","https://openalex.org/W4289523692","https://openalex.org/W4296992722","https://openalex.org/W4297263721","https://openalex.org/W4304689665","https://openalex.org/W4308623295","https://openalex.org/W4309511455","https://openalex.org/W4311246934"],"related_works":["https://openalex.org/W4319984117","https://openalex.org/W2373452650","https://openalex.org/W3200057063","https://openalex.org/W1969225559","https://openalex.org/W2394340714","https://openalex.org/W2373431535","https://openalex.org/W2370613685","https://openalex.org/W2034988225","https://openalex.org/W2376213619","https://openalex.org/W911845349"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
