{"id":"https://openalex.org/W4296962377","doi":"https://doi.org/10.1007/s13721-022-00378-y","title":"5-HTR2B and SLC6A3 as potential molecular targets of sertraline in the treatment of major depressive disorder: the use of bioinformatics and its practical implication","display_name":"5-HTR2B and SLC6A3 as potential molecular targets of sertraline in the treatment of major depressive disorder: the use of bioinformatics and its practical implication","publication_year":2022,"publication_date":"2022-09-21","ids":{"openalex":"https://openalex.org/W4296962377","doi":"https://doi.org/10.1007/s13721-022-00378-y"},"language":"en","primary_location":{"id":"doi:10.1007/s13721-022-00378-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13721-022-00378-y","pdf_url":null,"source":{"id":"https://openalex.org/S4210178532","display_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","issn_l":"2192-6662","issn":["2192-6662","2192-6670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110757567","display_name":"Ronaldo Rodrigues de Oliveira","orcid":null},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ronaldo R. de Oliveira","raw_affiliation_strings":["Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036566181","display_name":"Diana Kuhn","orcid":null},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Diana Kuhn","raw_affiliation_strings":["Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051845781","display_name":"Daiane Heidrich","orcid":"https://orcid.org/0000-0002-1010-5215"},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daiane Heidrich","raw_affiliation_strings":["Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]},{"raw_affiliation_string":"Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066458932","display_name":"Fl\u00e1vio Shansis","orcid":"https://orcid.org/0000-0003-0423-6291"},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio M. Shansis","raw_affiliation_strings":["Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046419501","display_name":"Rodrigo G. Ducati","orcid":"https://orcid.org/0000-0002-8783-8847"},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo G. Ducati","raw_affiliation_strings":["Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007083911","display_name":"Lu\u00eds Fernando Saraiva Macedo Timmers","orcid":"https://orcid.org/0000-0003-0399-5376"},"institutions":[{"id":"https://openalex.org/I1279799976","display_name":"Univates","ror":"https://ror.org/025fy2n80","country_code":"BR","type":"education","lineage":["https://openalex.org/I1279799976"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Fernando S. M. Timmers","raw_affiliation_strings":["Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil"],"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]},{"raw_affiliation_string":"Medical Sciences Graduate Program, Universidade do Vale do Taquari - Univates, Lajeado, Brazil","institution_ids":["https://openalex.org/I1279799976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5110757567"],"corresponding_institution_ids":["https://openalex.org/I1279799976"],"apc_list":{"value":2390,"currency":"EUR","value_usd":2990},"apc_paid":null,"fwci":0.351,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63173929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sertraline","display_name":"Sertraline","score":0.8875575065612793},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.7321942448616028},{"id":"https://openalex.org/keywords/reuptake-inhibitor","display_name":"Reuptake inhibitor","score":0.5529676079750061},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"Serotonin transporter","score":0.5178037881851196},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"Norepinephrine transporter","score":0.5127695202827454},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.48473450541496277},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4632030725479126},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.45241662859916687},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.44016748666763306},{"id":"https://openalex.org/keywords/serotonin-plasma-membrane-transport-proteins","display_name":"Serotonin Plasma Membrane Transport Proteins","score":0.431391179561615},{"id":"https://openalex.org/keywords/serotonin","display_name":"Serotonin","score":0.39273273944854736},{"id":"https://openalex.org/keywords/antidepressant","display_name":"Antidepressant","score":0.361017107963562},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2979564666748047},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.271595299243927},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24736332893371582},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"Norepinephrine","score":0.21095770597457886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20825424790382385}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.8875575065612793},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.7321942448616028},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.5529676079750061},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.5178037881851196},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.5127695202827454},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.48473450541496277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4632030725479126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45241662859916687},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44016748666763306},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.431391179561615},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.39273273944854736},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.361017107963562},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2979564666748047},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.271595299243927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24736332893371582},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.21095770597457886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20825424790382385},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s13721-022-00378-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13721-022-00378-y","pdf_url":null,"source":{"id":"https://openalex.org/S4210178532","display_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","issn_l":"2192-6662","issn":["2192-6662","2192-6670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Network Modeling Analysis in Health Informatics and Bioinformatics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.49000000953674316,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1975706042","https://openalex.org/W1976499671","https://openalex.org/W1986777050","https://openalex.org/W1999613945","https://openalex.org/W2005817231","https://openalex.org/W2007752072","https://openalex.org/W2008973569","https://openalex.org/W2012975576","https://openalex.org/W2018067258","https://openalex.org/W2031733304","https://openalex.org/W2032148429","https://openalex.org/W2039566040","https://openalex.org/W2040911489","https://openalex.org/W2045683699","https://openalex.org/W2049683048","https://openalex.org/W2057477511","https://openalex.org/W2065283382","https://openalex.org/W2071957747","https://openalex.org/W2073961314","https://openalex.org/W2079288585","https://openalex.org/W2083286337","https://openalex.org/W2084867767","https://openalex.org/W2086108346","https://openalex.org/W2089924047","https://openalex.org/W2090977130","https://openalex.org/W2100025509","https://openalex.org/W2126218492","https://openalex.org/W2128572087","https://openalex.org/W2129495111","https://openalex.org/W2130179883","https://openalex.org/W2132251402","https://openalex.org/W2157932883","https://openalex.org/W2167549547","https://openalex.org/W2171268876","https://openalex.org/W2192300636","https://openalex.org/W2293922813","https://openalex.org/W2338373933","https://openalex.org/W2398478519","https://openalex.org/W2411013142","https://openalex.org/W2478017657","https://openalex.org/W2485472464","https://openalex.org/W2508772170","https://openalex.org/W2521022333","https://openalex.org/W2587638657","https://openalex.org/W2631752818","https://openalex.org/W2643196631","https://openalex.org/W2730900010","https://openalex.org/W2741723075","https://openalex.org/W2752391795","https://openalex.org/W2756721774","https://openalex.org/W2788337440","https://openalex.org/W2789034326","https://openalex.org/W2793534579","https://openalex.org/W2794283350","https://openalex.org/W2898391595","https://openalex.org/W2898550972","https://openalex.org/W2901315113","https://openalex.org/W2901338096","https://openalex.org/W2901954088","https://openalex.org/W2912465696","https://openalex.org/W2913614159","https://openalex.org/W2922125887","https://openalex.org/W2944039373","https://openalex.org/W2946412700","https://openalex.org/W2948798985","https://openalex.org/W2955244195","https://openalex.org/W2982809992","https://openalex.org/W2987335406","https://openalex.org/W2992679405","https://openalex.org/W3024379418","https://openalex.org/W3036997165","https://openalex.org/W4211263234"],"related_works":["https://openalex.org/W4327766724","https://openalex.org/W1826125636","https://openalex.org/W2146172043","https://openalex.org/W2028937236","https://openalex.org/W2056107257","https://openalex.org/W2103745296","https://openalex.org/W2072407949","https://openalex.org/W4296962377","https://openalex.org/W2029024244","https://openalex.org/W2054453334"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
