{"id":"https://openalex.org/W4408675562","doi":"https://doi.org/10.1007/s13235-025-00629-3","title":"Stability of the Darwinian Dynamics: Effect of Intraspecific Competition and Human Intervention","display_name":"Stability of the Darwinian Dynamics: Effect of Intraspecific Competition and Human Intervention","publication_year":2025,"publication_date":"2025-03-20","ids":{"openalex":"https://openalex.org/W4408675562","doi":"https://doi.org/10.1007/s13235-025-00629-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/41020140"},"language":"en","primary_location":{"id":"doi:10.1007/s13235-025-00629-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13235-025-00629-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13235-025-00629-3.pdf","source":{"id":"https://openalex.org/S2502731256","display_name":"Dynamic Games and Applications","issn_l":"2153-0785","issn":["2153-0785","2153-0793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320186","host_organization_name":"Birkh\u00e4user","host_organization_lineage":["https://openalex.org/P4310320186","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Birkh\u00e4user","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dynamic Games and Applications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13235-025-00629-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080727503","display_name":"Mohammadreza Satouri","orcid":"https://orcid.org/0000-0003-2397-1785"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Mohammadreza Satouri","raw_affiliation_strings":["Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052272353","display_name":"Jafar Rezaei","orcid":"https://orcid.org/0000-0002-7407-9255"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jafar Rezaei","raw_affiliation_strings":["Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037705191","display_name":"Kate\u0159ina Sta\u0148kov\u00e1","orcid":"https://orcid.org/0000-0002-4519-0325"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kate\u0159ina Sta\u0148kov\u00e1","raw_affiliation_strings":["Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Technology, Policy and Management, Institute for Health Systems Science, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080727503"],"corresponding_institution_ids":["https://openalex.org/I98358874"],"apc_list":{"value":2390,"currency":"EUR","value_usd":2990},"apc_paid":{"value":2390,"currency":"EUR","value_usd":2990},"fwci":5.7268,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.95389144,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":"4","first_page":"1467","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraspecific-competition","display_name":"Intraspecific competition","score":0.668148398399353},{"id":"https://openalex.org/keywords/competition","display_name":"Competition (biology)","score":0.6386741995811462},{"id":"https://openalex.org/keywords/darwinism","display_name":"Darwinism","score":0.6152381896972656},{"id":"https://openalex.org/keywords/economics","display_name":"Economics","score":0.5193532705307007},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.49773743748664856},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.45749741792678833},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.4539681077003479},{"id":"https://openalex.org/keywords/mathematical-economics","display_name":"Mathematical economics","score":0.4293639361858368},{"id":"https://openalex.org/keywords/microeconomics","display_name":"Microeconomics","score":0.3298574686050415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.26031947135925293},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.23396778106689453},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20197245478630066},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.1921556293964386},{"id":"https://openalex.org/keywords/sociology","display_name":"Sociology","score":0.19129684567451477},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.18086650967597961}],"concepts":[{"id":"https://openalex.org/C131892835","wikidata":"https://www.wikidata.org/wiki/Q770985","display_name":"Intraspecific competition","level":2,"score":0.668148398399353},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.6386741995811462},{"id":"https://openalex.org/C196919123","wikidata":"https://www.wikidata.org/wiki/Q183493","display_name":"Darwinism","level":2,"score":0.6152381896972656},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.5193532705307007},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.49773743748664856},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.45749741792678833},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4539681077003479},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.4293639361858368},{"id":"https://openalex.org/C175444787","wikidata":"https://www.wikidata.org/wiki/Q39072","display_name":"Microeconomics","level":1,"score":0.3298574686050415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26031947135925293},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.23396778106689453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20197245478630066},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1921556293964386},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.19129684567451477},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18086650967597961},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s13235-025-00629-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13235-025-00629-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13235-025-00629-3.pdf","source":{"id":"https://openalex.org/S2502731256","display_name":"Dynamic Games and Applications","issn_l":"2153-0785","issn":["2153-0785","2153-0793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320186","host_organization_name":"Birkh\u00e4user","host_organization_lineage":["https://openalex.org/P4310320186","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Birkh\u00e4user","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dynamic Games and Applications","raw_type":"journal-article"},{"id":"pmid:41020140","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41020140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dynamic games and applications","raw_type":null},{"id":"pmh:oai:europepmc.org:11269265","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12460579","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12460579/pdf/13235_2025_Article_629.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12460579","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12460579/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dyn Games Appl","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13235-025-00629-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13235-025-00629-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13235-025-00629-3.pdf","source":{"id":"https://openalex.org/S2502731256","display_name":"Dynamic Games and Applications","issn_l":"2153-0785","issn":["2153-0785","2153-0793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320186","host_organization_name":"Birkh\u00e4user","host_organization_lineage":["https://openalex.org/P4310320186","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Birkh\u00e4user","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dynamic Games and Applications","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1032995524","display_name":null,"funder_award_id":"955708","funder_id":"https://openalex.org/F4320338438","funder_display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions"},{"id":"https://openalex.org/G3876645106","display_name":null,"funder_award_id":"VI.Vidi.213.139","funder_id":"https://openalex.org/F5660121338","funder_display_name":"Exacte en Natuurwetenschappen"},{"id":"https://openalex.org/G531330455","display_name":null,"funder_award_id":"VI.Vidi.213.139","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7567061549","display_name":null,"funder_award_id":"OCENW.KLEIN.277","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7711722093","display_name":null,"funder_award_id":"955708","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320338438","display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","ror":null},{"id":"https://openalex.org/F5660121338","display_name":"Exacte en Natuurwetenschappen","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4408675562.pdf"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W176968718","https://openalex.org/W265679918","https://openalex.org/W1534391781","https://openalex.org/W1547389208","https://openalex.org/W1583399309","https://openalex.org/W1584496882","https://openalex.org/W1979985168","https://openalex.org/W1987012261","https://openalex.org/W1988769349","https://openalex.org/W1991083334","https://openalex.org/W1997175519","https://openalex.org/W2001331101","https://openalex.org/W2002903734","https://openalex.org/W2004778468","https://openalex.org/W2009419750","https://openalex.org/W2023560061","https://openalex.org/W2038960430","https://openalex.org/W2039766809","https://openalex.org/W2045166891","https://openalex.org/W2046530892","https://openalex.org/W2067032165","https://openalex.org/W2069448515","https://openalex.org/W2080860239","https://openalex.org/W2089135124","https://openalex.org/W2118498406","https://openalex.org/W2123558100","https://openalex.org/W2129970266","https://openalex.org/W2140553733","https://openalex.org/W2140650011","https://openalex.org/W2162131437","https://openalex.org/W2166091580","https://openalex.org/W2176409316","https://openalex.org/W2225885095","https://openalex.org/W2335679869","https://openalex.org/W2346244352","https://openalex.org/W2407421401","https://openalex.org/W2466620468","https://openalex.org/W2511644045","https://openalex.org/W2512030669","https://openalex.org/W2616163073","https://openalex.org/W2735758359","https://openalex.org/W2769410400","https://openalex.org/W2770572337","https://openalex.org/W2794384834","https://openalex.org/W2885596446","https://openalex.org/W2888992486","https://openalex.org/W2889627012","https://openalex.org/W2909182143","https://openalex.org/W2935777212","https://openalex.org/W2936045790","https://openalex.org/W2948599900","https://openalex.org/W2949580432","https://openalex.org/W2950793087","https://openalex.org/W2951890973","https://openalex.org/W2952088649","https://openalex.org/W2998744531","https://openalex.org/W3016753949","https://openalex.org/W3087902906","https://openalex.org/W3103384701","https://openalex.org/W3110733720","https://openalex.org/W3122047258","https://openalex.org/W3129959378","https://openalex.org/W3130860691","https://openalex.org/W3142541826","https://openalex.org/W3190138825","https://openalex.org/W3198461753","https://openalex.org/W4221042119","https://openalex.org/W4303415224","https://openalex.org/W4321600601","https://openalex.org/W4327860547","https://openalex.org/W4366774818","https://openalex.org/W4386422534","https://openalex.org/W4387574341","https://openalex.org/W4389267298","https://openalex.org/W4389389126","https://openalex.org/W4392518359","https://openalex.org/W4392968989"],"related_works":["https://openalex.org/W4395074218","https://openalex.org/W1525303497","https://openalex.org/W2811459610","https://openalex.org/W4245136235","https://openalex.org/W2004764425","https://openalex.org/W4393861002","https://openalex.org/W2164605607","https://openalex.org/W2912837731","https://openalex.org/W50819732","https://openalex.org/W1980601220"],"abstract_inverted_index":{"We":[0,76,105],"analyze":[1,77],"the":[2,14,25,34,50,79,84,90,101,112,120,128,134,139,162,203,212],"stability":[3,82],"of":[4,8,16,27,58,83,95,100,127,136,138,148,202,205,214],"a":[5,9,43,175],"game-theoretic":[6],"model":[7],"polymorphic":[10],"eco-evolutionary":[11,86,141,146],"system":[12,35],"in":[13,187],"presence":[15],"human":[17,29,176,206],"intervention.":[18],"The":[19,196],"goal":[20],"is":[21],"to":[22,73,123,132,171,228],"understand":[23],"how":[24,78],"intensity":[26],"this":[28,47],"intervention":[30],"and":[31,60,81,93,143,151,193,208],"competition":[32,96,210],"within":[33,150],"impact":[36,204],"its":[37],"stability,":[38],"with":[39,225],"cancer":[40,62,85,98,149,163],"treatment":[41,91,164],"as":[42,186],"case":[44,48,165],"study.":[45],"In":[46,116],"study,":[49,166],"physician":[51],"applies":[52],"anti-cancer":[53],"treatment,":[54],"while":[55],"cancer,":[56],"consisting":[57],"treatment-sensitive":[59],"treatment-resistant":[61],"cells,":[63],"responds":[64],"by":[65],"evolving":[66,219],"more":[67],"or":[68,181,217],"less":[69],"treatment-induced":[70],"resistance,":[71,190],"according":[72],"Darwinian":[74,183],"evolution.":[75],"existence":[80],"equilibria":[87,142],"depend":[88],"on":[89,161,211],"dose":[92],"rate":[94],"between":[97],"cells":[99],"two":[102],"different":[103],"types.":[104],"also":[106],"identify":[107],"initial":[108],"conditions":[109],"for":[110],"which":[111],"resistance":[113],"grows":[114],"unbounded.":[115],"addition,":[117],"we":[118,157],"adopt":[119],"level-set":[121],"method":[122],"find":[124],"viscosity":[125],"solutions":[126],"corresponding":[129],"Hamilton-Jacobi":[130],"equation":[131],"estimate":[133],"basins":[135],"attraction":[137],"found":[140],"simulate":[144],"typical":[145],"dynamics":[147],"outside":[152],"these":[153],"estimated":[154],"basins.":[155],"While":[156],"illustrate":[158],"our":[159,200,226],"results":[160,198],"they":[167],"can":[168],"be":[169],"generalized":[170],"any":[172],"situation":[173],"where":[174],"aims":[177],"at":[178],"containing,":[179,215],"eradicating,":[180,216],"saving":[182,218],"systems,":[184],"such":[185,230],"managing":[188],"antimicrobial":[189],"fisheries":[191],"management,":[192],"pest":[194],"management.":[195],"obtained":[197],"help":[199,223],"understanding":[201],"interventions":[207],"intraspecific":[209],"possibility":[213],"species.":[220],"This":[221],"will":[222],"us":[224],"ability":[227],"control":[229],"systems.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}