{"id":"https://openalex.org/W4403245102","doi":"https://doi.org/10.1007/s13222-024-00486-1","title":"Integration of FAERS, DrugBank and SIDER Data for Machine Learning-based Detection of Adverse Drug Reactions","display_name":"Integration of FAERS, DrugBank and SIDER Data for Machine Learning-based Detection of Adverse Drug Reactions","publication_year":2024,"publication_date":"2024-10-09","ids":{"openalex":"https://openalex.org/W4403245102","doi":"https://doi.org/10.1007/s13222-024-00486-1"},"language":"en","primary_location":{"id":"doi:10.1007/s13222-024-00486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13222-024-00486-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13222-024-00486-1.pdf","source":{"id":"https://openalex.org/S73012565","display_name":"Datenbank-Spektrum","issn_l":"1610-1995","issn":["1610-1995","1618-2162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Datenbank-Spektrum","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13222-024-00486-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021074250","display_name":"Tobias Schreier","orcid":null},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I70451448","display_name":"HAW Hamburg","ror":"https://ror.org/00fkqwx76","country_code":"DE","type":"education","lineage":["https://openalex.org/I70451448"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tobias Schreier","raw_affiliation_strings":["Computer Science, Hamburg University of Applied Sciences, Hamburg, Germany"],"affiliations":[{"raw_affiliation_string":"Computer Science, Hamburg University of Applied Sciences, Hamburg, Germany","institution_ids":["https://openalex.org/I70451448","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067255721","display_name":"Marina Tropmann-Frick","orcid":"https://orcid.org/0000-0003-1623-5309"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I70451448","display_name":"HAW Hamburg","ror":"https://ror.org/00fkqwx76","country_code":"DE","type":"education","lineage":["https://openalex.org/I70451448"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marina Tropmann-Frick","raw_affiliation_strings":["Computer Science, Hamburg University of Applied Sciences, Hamburg, Germany"],"affiliations":[{"raw_affiliation_string":"Computer Science, Hamburg University of Applied Sciences, Hamburg, Germany","institution_ids":["https://openalex.org/I70451448","https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074592003","display_name":"Ruwen B\u00f6hm","orcid":"https://orcid.org/0000-0003-1007-3011"},"institutions":[{"id":"https://openalex.org/I4210102839","display_name":"Th\u00fcringer Aufbaubank","ror":"https://ror.org/01axmbr32","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210102839"]},{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruwen B\u00f6hm","raw_affiliation_strings":["Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany","ScoraTec R&D, Erfurt, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]},{"raw_affiliation_string":"ScoraTec R&D, Erfurt, Germany","institution_ids":["https://openalex.org/I4210102839"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021074250"],"corresponding_institution_ids":["https://openalex.org/I159176309","https://openalex.org/I70451448"],"apc_list":{"value":2380,"currency":"EUR","value_usd":2890},"apc_paid":{"value":2380,"currency":"EUR","value_usd":2890},"fwci":0.7311,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69161254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"24","issue":"3","first_page":"233","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.8811229467391968},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"Pharmacovigilance","score":0.808813214302063},{"id":"https://openalex.org/keywords/adverse-event-reporting-system","display_name":"Adverse Event Reporting System","score":0.7642167806625366},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6601116061210632},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6450557112693787},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5985503196716309},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5589320063591003},{"id":"https://openalex.org/keywords/event","display_name":"Event (particle physics)","score":0.43158185482025146},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.403391033411026},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.26920104026794434},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.252281129360199},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19423121213912964},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1495712697505951}],"concepts":[{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.8811229467391968},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.808813214302063},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.7642167806625366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6601116061210632},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6450557112693787},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5985503196716309},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5589320063591003},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.43158185482025146},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.403391033411026},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.26920104026794434},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.252281129360199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19423121213912964},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1495712697505951},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s13222-024-00486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13222-024-00486-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13222-024-00486-1.pdf","source":{"id":"https://openalex.org/S73012565","display_name":"Datenbank-Spektrum","issn_l":"1610-1995","issn":["1610-1995","1618-2162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Datenbank-Spektrum","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s13222-024-00486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13222-024-00486-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13222-024-00486-1.pdf","source":{"id":"https://openalex.org/S73012565","display_name":"Datenbank-Spektrum","issn_l":"1610-1995","issn":["1610-1995","1618-2162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Datenbank-Spektrum","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403245102.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1524926404","https://openalex.org/W1988100739","https://openalex.org/W2015487160","https://openalex.org/W2126105956","https://openalex.org/W2136127280","https://openalex.org/W2142572836","https://openalex.org/W2145578524","https://openalex.org/W2148143831","https://openalex.org/W2158299492","https://openalex.org/W2309832917","https://openalex.org/W2472705372","https://openalex.org/W2911375005","https://openalex.org/W2922082445","https://openalex.org/W2955219525","https://openalex.org/W2962862931","https://openalex.org/W3014266233","https://openalex.org/W3120115411","https://openalex.org/W4283574183","https://openalex.org/W4307468223","https://openalex.org/W4388615774"],"related_works":["https://openalex.org/W2365158734","https://openalex.org/W2009313526","https://openalex.org/W2465211533","https://openalex.org/W2157969515","https://openalex.org/W129624489","https://openalex.org/W4387804095","https://openalex.org/W2767891136","https://openalex.org/W4388615774","https://openalex.org/W4393344886","https://openalex.org/W4392585804"],"abstract_inverted_index":{"Abstract":[0],"Traditionally,":[1],"disproportionality":[2],"analysis":[3],"(DPA)":[4],"methods":[5,15,42,186],"are":[6,89,105,166],"employed":[7],"for":[8,95,171,187],"signal":[9,35,188],"detection":[10,36,189],"in":[11,190],"pharmacovigilance,":[12],"but":[13],"these":[14],"utilize":[16],"only":[17],"a":[18,50,178],"limited":[19],"portion":[20],"of":[21,144],"the":[22,57,93,99,120,142,149,157,167],"data":[23,55,68],"available":[24],"from":[25,56,69,79,87],"spontaneous":[26],"event":[27,160],"reports":[28],"(SERs).":[29],"This":[30],"research":[31],"aims":[32],"to":[33,91,136,183],"enhance":[34],"by":[37,52],"applying":[38],"machine":[39],"learning":[40],"(ML)":[41],"that":[43,113,156],"can":[44],"leverage":[45],"additional":[46,133],"data.":[47],"We":[48],"create":[49],"dataset":[51,94],"integrating":[53],"SER":[54],"FDA":[58],"Adverse":[59],"Event":[60],"Reporting":[61],"System":[62],"(FAERS)":[63],"with":[64,119],"biological":[65],"and":[66,71,129,138,162],"chemical":[67],"DrugBank,":[70],"information":[72],"on":[73,107],"known":[74,85],"adverse":[75],"drug":[76,158],"reactions":[77],"(ADRs)":[78],"Side":[80],"Effect":[81],"Resource":[82],"(SIDER).":[83],"The":[84],"ADRs":[86],"SIDER":[88],"used":[90],"label":[92],"ML":[96,103,114,145,175],"training.":[97],"Using":[98],"AutoML":[100],"library":[101],"TPOT,":[102],"models":[104,176],"trained":[106,118],"this":[108],"dataset.":[109],"Our":[110],"findings":[111],"indicate":[112],"models,":[115],"even":[116],"when":[117],"same":[121],"features":[122,134,170],"as":[123],"DPA":[124,185],"methods,":[125],"achieve":[126],"higher":[127],"recall":[128],"precision.":[130],"Moreover,":[131],"incorporating":[132],"related":[135],"drugs":[137],"events":[139],"significantly":[140],"boosts":[141],"performance":[143],"models.":[146],"Analysis":[147],"using":[148],"explainable":[150],"AI":[151],"(XAI)":[152],"technique":[153],"SHAP":[154],"reveals":[155],"name,":[159,161],"fifth-level":[163],"ATC":[164],"code":[165],"most":[168],"influential":[169],"model":[172],"predictions.":[173],"These":[174],"offer":[177],"promising":[179],"alternative":[180],"or":[181],"supplement":[182],"conventional":[184],"pharmacovigilance.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-03-11T06:11:40.159057","created_date":"2025-10-10T00:00:00"}