{"id":"https://openalex.org/W2016935849","doi":"https://doi.org/10.1007/s12064-013-0186-3","title":"Robustness, canalyzing functions and systems design","display_name":"Robustness, canalyzing functions and systems design","publication_year":2013,"publication_date":"2013-09-17","ids":{"openalex":"https://openalex.org/W2016935849","doi":"https://doi.org/10.1007/s12064-013-0186-3","mag":"2016935849","pmid":"https://pubmed.ncbi.nlm.nih.gov/24045959"},"language":"en","primary_location":{"id":"doi:10.1007/s12064-013-0186-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12064-013-0186-3","pdf_url":null,"source":{"id":"https://openalex.org/S12148721","display_name":"Theory in Biosciences","issn_l":"1431-7613","issn":["1431-7613","1611-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in Biosciences","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1210.7719","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053941878","display_name":"Johannes Rauh","orcid":"https://orcid.org/0000-0001-6411-7775"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210091327","display_name":"Max Planck Institute for Mathematics in the Sciences","ror":"https://ror.org/00ez2he07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210091327"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Rauh","raw_affiliation_strings":["Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, 04103, Leipzig, Germany, jrauh@mis.mpg.de","Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, 04103, Leipzig, Germany, jrauh@mis.mpg.de","institution_ids":["https://openalex.org/I4210091327"]},{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany#TAB#","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065926474","display_name":"Nihat Ay","orcid":"https://orcid.org/0000-0002-8527-2579"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I4210091327","display_name":"Max Planck Institute for Mathematics in the Sciences","ror":"https://ror.org/00ez2he07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210091327"]},{"id":"https://openalex.org/I4210119712","display_name":"Max Planck Institute for Mathematics","ror":"https://ror.org/02dh8ja68","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210119712"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nihat Ay","raw_affiliation_strings":["Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, 04103, Leipzig, Germany","Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM , 87501, USA","Santa Fe Institute","Max Planck Institute for Mathematics in the Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210091327"]},{"raw_affiliation_string":"Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM , 87501, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Santa Fe Institute","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences","institution_ids":["https://openalex.org/I4210119712","https://openalex.org/I4210091327"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053941878"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210091327"],"apc_list":{"value":2290,"currency":"EUR","value_usd":2890},"apc_paid":null,"fwci":2.8817,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89064691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"133","issue":"2","first_page":"63","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12069","display_name":"Commutative Algebra and Its Applications","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2602","display_name":"Algebra and Number Theory"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12069","display_name":"Commutative Algebra and Its Applications","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2602","display_name":"Algebra and Number Theory"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11435","display_name":"Polynomial and algebraic computation","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6932823657989502},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.5994885563850403},{"id":"https://openalex.org/keywords/random-variable","display_name":"Random variable","score":0.5545286536216736},{"id":"https://openalex.org/keywords/joint-probability-distribution","display_name":"Joint probability distribution","score":0.5472277998924255},{"id":"https://openalex.org/keywords/conditional-independence","display_name":"Conditional independence","score":0.5268358588218689},{"id":"https://openalex.org/keywords/conditional-probability-distribution","display_name":"Conditional probability distribution","score":0.5085402727127075},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4637138843536377},{"id":"https://openalex.org/keywords/probability-distribution","display_name":"Probability distribution","score":0.42881423234939575},{"id":"https://openalex.org/keywords/markov-process","display_name":"Markov process","score":0.42229872941970825},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40000802278518677},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1694972813129425}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6932823657989502},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5994885563850403},{"id":"https://openalex.org/C122123141","wikidata":"https://www.wikidata.org/wiki/Q176623","display_name":"Random variable","level":2,"score":0.5545286536216736},{"id":"https://openalex.org/C18653775","wikidata":"https://www.wikidata.org/wiki/Q1333358","display_name":"Joint probability distribution","level":2,"score":0.5472277998924255},{"id":"https://openalex.org/C79772020","wikidata":"https://www.wikidata.org/wiki/Q5159264","display_name":"Conditional independence","level":2,"score":0.5268358588218689},{"id":"https://openalex.org/C43555835","wikidata":"https://www.wikidata.org/wiki/Q2300258","display_name":"Conditional probability distribution","level":2,"score":0.5085402727127075},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4637138843536377},{"id":"https://openalex.org/C149441793","wikidata":"https://www.wikidata.org/wiki/Q200726","display_name":"Probability distribution","level":2,"score":0.42881423234939575},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.42229872941970825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40000802278518677},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1694972813129425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009716","descriptor_name":"Numerical Analysis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009716","descriptor_name":"Numerical Analysis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009716","descriptor_name":"Numerical Analysis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1007/s12064-013-0186-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12064-013-0186-3","pdf_url":null,"source":{"id":"https://openalex.org/S12148721","display_name":"Theory in Biosciences","issn_l":"1431-7613","issn":["1431-7613","1611-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in Biosciences","raw_type":"journal-article"},{"id":"pmid:24045959","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24045959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in biosciences = Theorie in den Biowissenschaften","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.591.2946","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.591.2946","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"http://www.santafe.edu/media/workingpapers/12-11-021.pdf","raw_type":"text"},{"id":"pmh:oai:arXiv.org:1210.7719","is_oa":true,"landing_page_url":"https://arxiv.org/abs/1210.7719","pdf_url":"https://arxiv.org/pdf/1210.7719","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1001.3972","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1001.3972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mis.mpg.de/preprints/2012/preprint2012_66.pdf","raw_type":"text"},{"id":"pmh:oai:edoc.mpg.de:688114","is_oa":false,"landing_page_url":"http://edoc.mpg.de/688114","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theory in Biosciences (2013)","raw_type":"Article"},{"id":"pmh:oai:null:11420/14346","is_oa":false,"landing_page_url":"http://hdl.handle.net/11420/14346","pdf_url":null,"source":{"id":"https://openalex.org/S4306401751","display_name":"tub.dok (Hamburg University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I884043246","host_organization_name":"Hamburg University of Technology","host_organization_lineage":["https://openalex.org/I884043246"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1210.7719","is_oa":true,"landing_page_url":"https://arxiv.org/abs/1210.7719","pdf_url":"https://arxiv.org/pdf/1210.7719","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016935849.pdf","grobid_xml":"https://content.openalex.org/works/W2016935849.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W134271320","https://openalex.org/W1534257613","https://openalex.org/W1877021405","https://openalex.org/W1963721973","https://openalex.org/W1965869439","https://openalex.org/W1976603748","https://openalex.org/W1977940795","https://openalex.org/W1994094326","https://openalex.org/W2051494150","https://openalex.org/W2060562744","https://openalex.org/W2063104797","https://openalex.org/W2066191910","https://openalex.org/W2086157622","https://openalex.org/W2097263107","https://openalex.org/W2103723044","https://openalex.org/W2108020239","https://openalex.org/W2111123076","https://openalex.org/W2163411200","https://openalex.org/W2168338628","https://openalex.org/W2168359188","https://openalex.org/W2320223248","https://openalex.org/W2952898851","https://openalex.org/W4237156879","https://openalex.org/W4299815636","https://openalex.org/W4300432631"],"related_works":["https://openalex.org/W2063886698","https://openalex.org/W1987264987","https://openalex.org/W2951801950","https://openalex.org/W4297670780","https://openalex.org/W4244332233","https://openalex.org/W1539131693","https://openalex.org/W4306317269","https://openalex.org/W162901985","https://openalex.org/W2396056823","https://openalex.org/W2964200874"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}
