{"id":"https://openalex.org/W2128060397","doi":"https://doi.org/10.1007/s12064-011-0126-z","title":"Multi-scale genetic dynamic modelling II: application to synthetic biology","display_name":"Multi-scale genetic dynamic modelling II: application to synthetic biology","publication_year":2011,"publication_date":"2011-04-20","ids":{"openalex":"https://openalex.org/W2128060397","doi":"https://doi.org/10.1007/s12064-011-0126-z","mag":"2128060397","pmid":"https://pubmed.ncbi.nlm.nih.gov/21509695"},"language":"en","primary_location":{"id":"doi:10.1007/s12064-011-0126-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12064-011-0126-z","pdf_url":null,"source":{"id":"https://openalex.org/S12148721","display_name":"Theory in Biosciences","issn_l":"1431-7613","issn":["1431-7613","1611-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in Biosciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078923248","display_name":"Markus Kirkilionis","orcid":"https://orcid.org/0000-0002-0223-9774"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Markus Kirkilionis","raw_affiliation_strings":["Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK. mak@maths.warwick.ac.uk","Mathematics Institute, University of Warwick, Coventry , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK. mak@maths.warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Mathematics Institute, University of Warwick, Coventry , UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077716942","display_name":"Ulrich Janus","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ulrich Janus","raw_affiliation_strings":["Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK","Mathematics Institute, University of Warwick, Coventry , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Mathematics Institute, University of Warwick, Coventry , UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090293012","display_name":"Luca Sbano","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Sbano","raw_affiliation_strings":["I.T.I.S. \u201cVon Neumann\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.T.I.S. \u201cVon Neumann\u201d, Rome, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078923248"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":{"value":2290,"currency":"EUR","value_usd":2890},"apc_paid":null,"fwci":0.5323,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66650826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"130","issue":"3","first_page":"183","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9861000180244446,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philosophy-of-biology","display_name":"Philosophy of biology","score":0.6323329210281372},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5528525710105896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.542540431022644},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5217120051383972},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.44818782806396484},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3607223629951477},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.0852465033531189},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07639256119728088},{"id":"https://openalex.org/keywords/philosophy-of-science","display_name":"Philosophy of science","score":0.07451429963111877},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.07205307483673096}],"concepts":[{"id":"https://openalex.org/C180182882","wikidata":"https://www.wikidata.org/wiki/Q1028964","display_name":"Philosophy of biology","level":3,"score":0.6323329210281372},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5528525710105896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.542540431022644},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5217120051383972},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.44818782806396484},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3607223629951477},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0852465033531189},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07639256119728088},{"id":"https://openalex.org/C110099512","wikidata":"https://www.wikidata.org/wiki/Q59115","display_name":"Philosophy of science","level":2,"score":0.07451429963111877},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.07205307483673096},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12064-011-0126-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12064-011-0126-z","pdf_url":null,"source":{"id":"https://openalex.org/S12148721","display_name":"Theory in Biosciences","issn_l":"1431-7613","issn":["1431-7613","1611-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in Biosciences","raw_type":"journal-article"},{"id":"pmid:21509695","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21509695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theory in biosciences = Theorie in den Biowissenschaften","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W456191","https://openalex.org/W62564358","https://openalex.org/W144423133","https://openalex.org/W193310603","https://openalex.org/W607204531","https://openalex.org/W1482637285","https://openalex.org/W1522641732","https://openalex.org/W1547614230","https://openalex.org/W1573008071","https://openalex.org/W1578740502","https://openalex.org/W1591758727","https://openalex.org/W1599969036","https://openalex.org/W1603896637","https://openalex.org/W1603900493","https://openalex.org/W1645305843","https://openalex.org/W1965844459","https://openalex.org/W1978374599","https://openalex.org/W1980065233","https://openalex.org/W1982769595","https://openalex.org/W1991008498","https://openalex.org/W1995514232","https://openalex.org/W1996983929","https://openalex.org/W2007085003","https://openalex.org/W2013080075","https://openalex.org/W2014150977","https://openalex.org/W2017379538","https://openalex.org/W2017862866","https://openalex.org/W2022891974","https://openalex.org/W2023116290","https://openalex.org/W2034870347","https://openalex.org/W2040382593","https://openalex.org/W2050270735","https://openalex.org/W2050469077","https://openalex.org/W2050482128","https://openalex.org/W2061657565","https://openalex.org/W2073874317","https://openalex.org/W2084299509","https://openalex.org/W2084586898","https://openalex.org/W2089719600","https://openalex.org/W2091689926","https://openalex.org/W2095663918","https://openalex.org/W2100416355","https://openalex.org/W2102498314","https://openalex.org/W2105638592","https://openalex.org/W2108493072","https://openalex.org/W2117033519","https://openalex.org/W2118526609","https://openalex.org/W2123097315","https://openalex.org/W2134759932","https://openalex.org/W2135156700","https://openalex.org/W2137044504","https://openalex.org/W2137288771","https://openalex.org/W2140944735","https://openalex.org/W2144347639","https://openalex.org/W2150579154","https://openalex.org/W2152842787","https://openalex.org/W2153847750","https://openalex.org/W2154577805","https://openalex.org/W2161579455","https://openalex.org/W2164774980","https://openalex.org/W2167154952","https://openalex.org/W2168275195","https://openalex.org/W2170000137","https://openalex.org/W4246632628"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933","https://openalex.org/W2061542922"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2016-06-24T00:00:00"}