{"id":"https://openalex.org/W4281703706","doi":"https://doi.org/10.1007/s12021-022-09591-6","title":"MEA-ToolBox: an Open Source Toolbox for Standardized Analysis of Multi-Electrode Array Data","display_name":"MEA-ToolBox: an Open Source Toolbox for Standardized Analysis of Multi-Electrode Array Data","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4281703706","doi":"https://doi.org/10.1007/s12021-022-09591-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35680724"},"language":"en","primary_location":{"id":"doi:10.1007/s12021-022-09591-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12021-022-09591-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12021-022-09591-6.pdf","source":{"id":"https://openalex.org/S3444786","display_name":"Neuroinformatics","issn_l":"1539-2791","issn":["1539-2791","1559-0089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12021-022-09591-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042846764","display_name":"Michel Hu","orcid":"https://orcid.org/0000-0003-4600-144X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel Hu","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000602972","display_name":"Monica Frega","orcid":"https://orcid.org/0000-0002-9697-3282"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monica Frega","raw_affiliation_strings":["Department of Clinical Neurophysiology, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090031681","display_name":"Else A. Tolner","orcid":"https://orcid.org/0000-0002-6501-9971"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Else A. Tolner","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012664216","display_name":"Arn M. J. M. van den Maagdenberg","orcid":"https://orcid.org/0000-0002-9310-5535"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. M. J. M. van den Maagdenberg","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010865264","display_name":"Jean\u2010Philippe Frimat","orcid":"https://orcid.org/0000-0001-8313-4511"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"J. P. Frimat","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands. J.P.M.S.Frimat@lumc.nl","Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands. J.P.M.S.Frimat@lumc.nl","Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8313-4511","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands. J.P.M.S.Frimat@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands. J.P.M.S.Frimat@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003929961","display_name":"Joost le Feber","orcid":"https://orcid.org/0000-0002-0605-1437"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost le Feber","raw_affiliation_strings":["Department of Clinical Neurophysiology, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010865264"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.8378,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84796209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"1077","last_page":"1092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toolbox","display_name":"Toolbox","score":0.946993350982666},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7486705780029297},{"id":"https://openalex.org/keywords/raw-data","display_name":"Raw data","score":0.4993736743927002},{"id":"https://openalex.org/keywords/graphical-user-interface","display_name":"Graphical user interface","score":0.48171859979629517},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4704802334308624},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4599773585796356},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.42864280939102173},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4239470362663269},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.10577395558357239}],"concepts":[{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.946993350982666},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7486705780029297},{"id":"https://openalex.org/C132964779","wikidata":"https://www.wikidata.org/wiki/Q2110223","display_name":"Raw data","level":2,"score":0.4993736743927002},{"id":"https://openalex.org/C37789001","wikidata":"https://www.wikidata.org/wiki/Q782543","display_name":"Graphical user interface","level":2,"score":0.48171859979629517},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4704802334308624},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4599773585796356},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.42864280939102173},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4239470362663269},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.10577395558357239},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1007/s12021-022-09591-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12021-022-09591-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12021-022-09591-6.pdf","source":{"id":"https://openalex.org/S3444786","display_name":"Neuroinformatics","issn_l":"1539-2791","issn":["1539-2791","1559-0089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9588481","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588481","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinformatics","raw_type":"Text"},{"id":"pmid:35680724","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35680724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinformatics","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/f8dd8f30-fa57-4bef-9e1e-7893f791e34d","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/f8dd8f30-fa57-4bef-9e1e-7893f791e34d","pdf_url":"https://ris.utwente.nl/ws/files/283463999/Hu_2022_Mea_toolbox_an_open_source_toolbox_.pdf","source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hu, M, Frega, M, Tolner, E A, van den Maagdenberg, A M J M, Frimat, J P & le Feber, J 2022, 'MEA-ToolBox : an Open Source Toolbox for Standardized Analysis of Multi-Electrode Array Data', Neuroinformatics, vol. 20, no. 4, pp. 1077-1092. https://doi.org/10.1007/s12021-022-09591-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3502222","is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3502222","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroinformatics. HUMANA PRESS INC","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unige.it:11567/1233106","is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/1233106","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ris.utwente.nl:publications/f8dd8f30-fa57-4bef-9e1e-7893f791e34d","is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85131586248&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3502222","is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/3502222","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroinformatics","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1007/s12021-022-09591-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12021-022-09591-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12021-022-09591-6.pdf","source":{"id":"https://openalex.org/S3444786","display_name":"Neuroinformatics","issn_l":"1539-2791","issn":["1539-2791","1559-0089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1796601023","display_name":null,"funder_award_id":"024.003.001","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G2717753857","display_name":null,"funder_award_id":"40-08125-98-160","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G2898873767","display_name":"Netherlands Organ-on-Chip Initiative","funder_award_id":"024.003.001","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G420050720","display_name":null,"funder_award_id":"024.003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7367133829","display_name":null,"funder_award_id":"40-08125-98-160","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281703706.pdf","grobid_xml":"https://content.openalex.org/works/W4281703706.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1985007213","https://openalex.org/W1989581618","https://openalex.org/W2003900693","https://openalex.org/W2032756564","https://openalex.org/W2033463239","https://openalex.org/W2050795073","https://openalex.org/W2050995101","https://openalex.org/W2069461602","https://openalex.org/W2069751701","https://openalex.org/W2078749705","https://openalex.org/W2086236510","https://openalex.org/W2096493278","https://openalex.org/W2100243099","https://openalex.org/W2117384296","https://openalex.org/W2135952327","https://openalex.org/W2143798904","https://openalex.org/W2144993965","https://openalex.org/W2158948112","https://openalex.org/W2257423805","https://openalex.org/W2331903429","https://openalex.org/W2338149947","https://openalex.org/W2601813741","https://openalex.org/W2791680029","https://openalex.org/W2793422248","https://openalex.org/W2805469146","https://openalex.org/W2809404352","https://openalex.org/W2893064213","https://openalex.org/W2909240409","https://openalex.org/W2951614919","https://openalex.org/W2954254309","https://openalex.org/W2982393021","https://openalex.org/W3124734392","https://openalex.org/W3186658644"],"related_works":["https://openalex.org/W3200088983","https://openalex.org/W2243008534","https://openalex.org/W2561596083","https://openalex.org/W3161088745","https://openalex.org/W339959573","https://openalex.org/W135428843","https://openalex.org/W2948527927","https://openalex.org/W2135196975","https://openalex.org/W2990762041","https://openalex.org/W2381929017"],"abstract_inverted_index":{"Functional":[0],"assessment":[1],"of":[2,26,30,72,90,127,137],"in":[3,34,148],"vitro":[4],"neuronal":[5,196],"networks-of":[6],"relevance":[7],"for":[8,41,133,172],"disease":[9],"modelling":[10],"and":[11,24,102,109,121,139,182,210,239,244],"drug":[12],"testing-can":[13],"be":[14],"performed":[15],"using":[16],"multi-electrode":[17],"array":[18],"(MEA)":[19],"technology.":[20],"However,":[21],"the":[22,27,62,66,73,95,107,125,149,156,170,184,233],"handling":[23],"processing":[25],"large":[28],"amount":[29],"data":[31,142],"typically":[32],"generated":[33],"MEA":[35,83,193],"experiments":[36],"remains":[37],"a":[38,79,88,163,222],"huge":[39],"hurdle":[40],"researchers.":[42],"Various":[43],"software":[44],"packages":[45],"have":[46],"been":[47],"developed":[48],"to":[49,54,93,179,226],"tackle":[50,70],"this":[51],"issue,":[52],"but":[53],"date,":[55],"most":[56],"are":[57],"either":[58],"not":[59],"accessible":[60],"through":[61],"links":[63],"provided":[64],"by":[65],"authors":[67],"or":[68],"only":[69],"parts":[71],"analysis.":[74],"Here,":[75],"we":[76],"present":[77],"''MEA-ToolBox'',":[78],"free":[80],"open-source":[81],"general":[82],"analytical":[84],"toolbox":[85,234],"that":[86,232],"uses":[87],"variety":[89],"literature-based":[91],"algorithms":[92],"process":[94],"data,":[96],"detect":[97],"spikes":[98],"from":[99,143,195,199,207,218,228],"raw":[100],"recordings,":[101],"extract":[103,236],"information":[104,115],"at":[105],"both":[106],"single-channel":[108],"array-wide":[110],"network":[111],"level.":[112],"MEA-ToolBox":[113,130,159,188],"extracts":[114],"about":[116],"spike":[117],"trains,":[118],"burst-related":[119],"analysis":[120,157],"connectivity":[122],"metrics":[123],"without":[124],"need":[126,171],"manual":[128],"intervention.":[129],"is":[131,160],"tailored":[132],"comparing":[134],"different":[135],"sets":[136],"measurements":[138],"will":[140],"analyze":[141],"multiple":[144],"recorded":[145],"files":[146],"placed":[147],"same":[150],"folder":[151],"sequentially,":[152],"thus":[153,168],"considerably":[154],"streamlining":[155],"pipeline.":[158],"available":[161],"with":[162,212],"graphic":[164],"user":[165],"interface":[166],"(GUI)":[167],"eliminating":[169],"any":[173],"coding":[174],"expertise":[175],"while":[176],"offering":[177],"functionality":[178],"inspect,":[180],"explore":[181],"post-process":[183],"data.":[185],"As":[186],"proof-of-concept,":[187],"was":[189],"tested":[190],"on":[191],"earlier-published":[192],"recordings":[194],"networks":[197,216],"derived":[198,217],"human":[200],"induced":[201],"pluripotent":[202],"stem":[203],"cells":[204],"(hiPSCs)":[205],"obtained":[206],"healthy":[208,229],"subjects":[209],"patients":[211],"neurodevelopmental":[213],"disorders.":[214],"Neuronal":[215],"patient's":[219],"hiPSCs":[220],"showed":[221],"clear":[223],"phenotype":[224],"compared":[225],"those":[227],"subjects,":[230],"demonstrating":[231],"could":[235],"useful":[237],"parameters":[238],"assess":[240],"differences":[241],"between":[242],"normal":[243],"diseased":[245],"profiles.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
