{"id":"https://openalex.org/W4399716580","doi":"https://doi.org/10.1007/s11548-024-03201-3","title":"BrainLossNet: a fast, accurate and robust method to estimate brain volume loss from longitudinal MRI","display_name":"BrainLossNet: a fast, accurate and robust method to estimate brain volume loss from longitudinal MRI","publication_year":2024,"publication_date":"2024-06-16","ids":{"openalex":"https://openalex.org/W4399716580","doi":"https://doi.org/10.1007/s11548-024-03201-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/38879844"},"language":"en","primary_location":{"id":"doi:10.1007/s11548-024-03201-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11548-024-03201-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11548-024-03201-3.pdf","source":{"id":"https://openalex.org/S181408163","display_name":"International Journal of Computer Assisted Radiology and Surgery","issn_l":"1861-6410","issn":["1861-6410","1861-6429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computer Assisted Radiology and Surgery","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11548-024-03201-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057079579","display_name":"Roland Opfer","orcid":"https://orcid.org/0000-0002-9911-5478"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Opfer","raw_affiliation_strings":["Jung Diagnostics GmbH, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9911-5478","affiliations":[{"raw_affiliation_string":"Jung Diagnostics GmbH, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031373312","display_name":"Julia Kr\u00fcger","orcid":"https://orcid.org/0000-0001-9963-4588"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Kr\u00fcger","raw_affiliation_strings":["Jung Diagnostics GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jung Diagnostics GmbH, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078167377","display_name":"Thomas Buddenkotte","orcid":"https://orcid.org/0000-0003-4872-4246"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Buddenkotte","raw_affiliation_strings":["Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047876493","display_name":"Lothar Spies","orcid":"https://orcid.org/0000-0002-5012-9406"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lothar Spies","raw_affiliation_strings":["Jung Diagnostics GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jung Diagnostics GmbH, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083173883","display_name":"Finn Behrendt","orcid":"https://orcid.org/0000-0001-7191-6508"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I884043246","display_name":"Hamburg University of Technology","ror":"https://ror.org/04bs1pb34","country_code":"DE","type":"education","lineage":["https://openalex.org/I884043246"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Finn Behrendt","raw_affiliation_strings":["Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I884043246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071972650","display_name":"Sven Schippling","orcid":"https://orcid.org/0000-0002-6804-1795"},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sven Schippling","raw_affiliation_strings":["Multimodal Imaging in Neuroimmunological Diseases (MINDS), University of Zurich, Zurich, Switzerland","Neuroscience and Rare Diseases (NRD), Roche Pharma Research and Early Development (pRED), Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multimodal Imaging in Neuroimmunological Diseases (MINDS), University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience and Rare Diseases (NRD), Roche Pharma Research and Early Development (pRED), Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072841040","display_name":"Ralph Buchert","orcid":"https://orcid.org/0000-0002-0945-0724"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralph Buchert","raw_affiliation_strings":["Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. r.buchert@uke.de","Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0945-0724","affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. r.buchert@uke.de","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072841040"],"corresponding_institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.133,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77656946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"19","issue":"9","first_page":"1763","last_page":"1771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4964999854564667,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4964999854564667,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/percentile","display_name":"Percentile","score":0.5345417857170105},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4962959885597229},{"id":"https://openalex.org/keywords/interquartile-range","display_name":"Interquartile range","score":0.4804510772228241},{"id":"https://openalex.org/keywords/brain-size","display_name":"Brain size","score":0.44957977533340454},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.42110979557037354},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4170278012752533},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.41228795051574707},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39367911219596863},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3696401119232178},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2907888889312744},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.244319349527359},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.13902029395103455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1316421627998352},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12531113624572754},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07734155654907227}],"concepts":[{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.5345417857170105},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4962959885597229},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.4804510772228241},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.44957977533340454},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.42110979557037354},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4170278012752533},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.41228795051574707},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39367911219596863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3696401119232178},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2907888889312744},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.244319349527359},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13902029395103455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1316421627998352},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12531113624572754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07734155654907227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11548-024-03201-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11548-024-03201-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11548-024-03201-3.pdf","source":{"id":"https://openalex.org/S181408163","display_name":"International Journal of Computer Assisted Radiology and Surgery","issn_l":"1861-6410","issn":["1861-6410","1861-6429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computer Assisted Radiology and Surgery","raw_type":"journal-article"},{"id":"pmid:38879844","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38879844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of computer assisted radiology and surgery","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11365843","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11365843","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11365843/pdf/11548_2024_Article_3201.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Comput Assist Radiol Surg","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s11548-024-03201-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11548-024-03201-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11548-024-03201-3.pdf","source":{"id":"https://openalex.org/S181408163","display_name":"International Journal of Computer Assisted Radiology and Surgery","issn_l":"1861-6410","issn":["1861-6410","1861-6429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computer Assisted Radiology and Surgery","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335947","display_name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399716580.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2008758766","https://openalex.org/W2028942474","https://openalex.org/W2057739090","https://openalex.org/W2105991991","https://openalex.org/W2123021165","https://openalex.org/W2136145485","https://openalex.org/W2155298532","https://openalex.org/W2562276035","https://openalex.org/W2781313989","https://openalex.org/W2787740020","https://openalex.org/W2791064447","https://openalex.org/W2891631795","https://openalex.org/W2946204861","https://openalex.org/W2992848041","https://openalex.org/W3001235085","https://openalex.org/W3011340088","https://openalex.org/W3088813743","https://openalex.org/W3094985679","https://openalex.org/W3098269293","https://openalex.org/W3104164805","https://openalex.org/W3134020135","https://openalex.org/W3134937671","https://openalex.org/W3149798718","https://openalex.org/W4226497331","https://openalex.org/W4306863215","https://openalex.org/W4362736072","https://openalex.org/W4378085883","https://openalex.org/W4383377619"],"related_works":["https://openalex.org/W1681476849","https://openalex.org/W2487490720","https://openalex.org/W2793077515","https://openalex.org/W4292573045","https://openalex.org/W2126365059","https://openalex.org/W4386009577","https://openalex.org/W2981615369","https://openalex.org/W3130621552","https://openalex.org/W3048651736","https://openalex.org/W3183420953"],"abstract_inverted_index":{"PURPOSE:":[0],"MRI-derived":[1],"brain":[2,53],"volume":[3,72],"loss":[4],"(BVL)":[5],"is":[6,13,47,64,219],"widely":[7],"used":[8],"as":[9,215],"neurodegeneration":[10],"marker.":[11],"SIENA":[12,93],"state-of-the-art":[14],"for":[15,34,66,117,238,246],"BVL":[16,46,62,165,189,213,251],"measurement,":[17],"but":[18,217],"limited":[19],"by":[20,49],"long":[21],"computation":[22],"time.":[23],"Here":[24],"we":[25],"propose":[26],"\"BrainLossNet\",":[27],"a":[28,106,133],"convolutional":[29],"neural":[30],"network":[31],"(CNN)-based":[32],"method":[33],"BVL-estimation.":[35],"METHODS:":[36],"BrainLossNet":[37,79,91,154,197,207,236],"uses":[38],"CNN-based":[39],"non-linear":[40,50],"registration":[41,51],"of":[42,52,74,124,153,162,187,232,250],"baseline(BL)/follow-up(FU)":[43],"3D-T1w-MRI":[44,125],"pairs.":[45,256],"computed":[48],"parenchyma":[54],"masks":[55],"segmented":[56],"in":[57,96,128,138,172,180,190],"the":[58,70,75,139,163,173,181,191,211,244],"BL/FU":[59,84,98,111,130,255],"scans.":[60],"The":[61,158,185],"estimate":[63],"corrected":[65],"image":[67],"distortions":[68],"using":[69],"apparent":[71,188],"change":[73],"total":[76],"intracranial":[77],"volume.":[78],"was":[80,94,126,155,167,194],"trained":[81],"on":[82,208],"1525":[83],"pairs":[85,99,112,131],"from":[86,100,113,132,253],"83":[87],"scanners.":[88],"Agreement":[89],"between":[90],"and":[92,109],"assessed":[95],"225":[97],"94":[101],"MS":[102,174],"patients":[103],"acquired":[104,116,137],"with":[105,144,196],"single":[107,134],"scanner":[108],"268":[110],"52":[114],"scanners":[115,146],"various":[118,182],"indications.":[119],"Robustness":[120],"to":[121,225],"short-term":[122],"variability":[123],"compared":[127],"354":[129],"healthy":[135],"men":[136],"same":[140,212],"session":[141],"without":[142],"repositioning":[143],"116":[145],"(Frequently-Traveling-Human-Phantom":[147],"dataset,":[148,175],"FTHP).":[149],"RESULTS:":[150],"Processing":[151,230],"time":[152,231],"2-3":[156,233],"min.":[157],"median":[159],"[interquartile":[160],"range]":[161],"SIENA-BrainLossNet":[164],"difference":[166],"0.10%":[168],"[-":[169,177],"0.18%,":[170],"0.35%]":[171],"0.08%":[176],"0.14%,":[178],"0.28%]":[179],"indications":[183],"dataset.":[184],"distribution":[186],"FTHP":[192],"dataset":[193],"narrower":[195],"(p":[198],"=":[199],"0.036;":[200],"95th":[201],"percentile:":[202],"0.20%":[203],"vs":[204],"0.32%).":[205],"CONCLUSION:":[206],"average":[209],"provides":[210],"estimates":[214],"SIENA,":[216],"it":[218],"significantly":[220],"more":[221],"robust,":[222],"probably":[223],"due":[224],"its":[226],"built-in":[227],"distortion":[228],"correction.":[229],"min":[234],"makes":[235],"suitable":[237],"clinical":[239,248],"routine.":[240],"This":[241],"can":[242],"pave":[243],"way":[245],"widespread":[247],"use":[249],"estimation":[252],"intra-scanner":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}