{"id":"https://openalex.org/W4412102191","doi":"https://doi.org/10.1007/s11517-025-03400-3","title":"Non-specific neck pain evaluation using functional linear models with the limma correction","display_name":"Non-specific neck pain evaluation using functional linear models with the limma correction","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4412102191","doi":"https://doi.org/10.1007/s11517-025-03400-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40627239"},"language":"en","primary_location":{"id":"doi:10.1007/s11517-025-03400-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-025-03400-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-025-03400-3.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11517-025-03400-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093639278","display_name":"Elisa Arag\u00f3n-Basanta","orcid":null},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Elisa Arag\u00f3n-Basanta","raw_affiliation_strings":["Instituto Universitario de Ingenier\u00eda Mec\u00e1nica y Biomec\u00e1nica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, Valencia, 46022, Spain. mearba@doctor.upv.es"],"raw_orcid":"https://orcid.org/0009-0000-2890-9062","affiliations":[{"raw_affiliation_string":"Instituto Universitario de Ingenier\u00eda Mec\u00e1nica y Biomec\u00e1nica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, Valencia, 46022, Spain. mearba@doctor.upv.es","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076964072","display_name":"Guillermo Ayala","orcid":"https://orcid.org/0000-0002-6231-2865"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillermo Ayala","raw_affiliation_strings":["Departamento de Estad\u00edstica e Investigaci\u00f3n Operativa, Facultad de Matem\u00e1ticas, Universitat de Val\u00e9ncia, Avda Vicent Andr\u00e9s Estell\u00e9s s/n, Burjassot, 46100, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Estad\u00edstica e Investigaci\u00f3n Operativa, Facultad de Matem\u00e1ticas, Universitat de Val\u00e9ncia, Avda Vicent Andr\u00e9s Estell\u00e9s s/n, Burjassot, 46100, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085867063","display_name":"\u00c1lvaro Page","orcid":"https://orcid.org/0000-0002-5432-310X"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Page","raw_affiliation_strings":["Instituto Universitario de Ingenier\u00eda Mec\u00e1nica y Biomec\u00e1nica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, Valencia, 46022, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Universitario de Ingenier\u00eda Mec\u00e1nica y Biomec\u00e1nica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, Valencia, 46022, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108849163","display_name":"Pilar Serra-A\u00f1\u00f3","orcid":null},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Serra-A\u00f1\u00f3","raw_affiliation_strings":["Departamento de Fisioterapia, Universitat de Val\u00e9ncia, Gasc\u00f3 Oliag 5, Valencia, 46010, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisioterapia, Universitat de Val\u00e9ncia, Gasc\u00f3 Oliag 5, Valencia, 46010, Spain","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5093639278"],"corresponding_institution_ids":["https://openalex.org/I60053951"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":{"value":2890,"currency":"EUR","value_usd":3690},"fwci":1.0211,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.76480541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"63","issue":"11","first_page":"3435","last_page":"3446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10630","display_name":"Orthopedic Surgery and Rehabilitation","score":0.9174000024795532,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.6531731486320496},{"id":"https://openalex.org/keywords/acceleration","display_name":"Acceleration","score":0.640778124332428},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.6373883485794067},{"id":"https://openalex.org/keywords/kinematics","display_name":"Kinematics","score":0.6096040606498718},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.5322902798652649},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.5162953734397888},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4317484498023987},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.4156598150730133},{"id":"https://openalex.org/keywords/linear-model","display_name":"Linear model","score":0.41258540749549866},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07965660095214844}],"concepts":[{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.6531731486320496},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.640778124332428},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.6373883485794067},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.6096040606498718},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.5322902798652649},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5162953734397888},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4317484498023987},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.4156598150730133},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.41258540749549866},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07965660095214844},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019547","descriptor_name":"Neck Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11517-025-03400-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-025-03400-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-025-03400-3.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},{"id":"pmid:40627239","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40627239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & biological engineering & computing","raw_type":null},{"id":"pmh:oai:europepmc.org:11442157","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12634767","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12634767/pdf/11517_2025_Article_3400.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s11517-025-03400-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-025-03400-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-025-03400-3.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412102191.pdf","grobid_xml":"https://content.openalex.org/works/W4412102191.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W40379270","https://openalex.org/W1534176151","https://openalex.org/W1596515083","https://openalex.org/W1925427981","https://openalex.org/W1964302726","https://openalex.org/W1973094248","https://openalex.org/W2060224765","https://openalex.org/W2081098333","https://openalex.org/W2081205207","https://openalex.org/W2110065044","https://openalex.org/W2143552803","https://openalex.org/W2145717250","https://openalex.org/W2146512944","https://openalex.org/W2147471105","https://openalex.org/W2148443418","https://openalex.org/W2193652713","https://openalex.org/W2304805159","https://openalex.org/W2542161862","https://openalex.org/W2547023295","https://openalex.org/W2789789380","https://openalex.org/W2913983404","https://openalex.org/W2972494851","https://openalex.org/W2996370717","https://openalex.org/W3005486941","https://openalex.org/W3010843423","https://openalex.org/W3109410822","https://openalex.org/W3125065802","https://openalex.org/W3135507173","https://openalex.org/W3193594609","https://openalex.org/W4212848594","https://openalex.org/W4214482010","https://openalex.org/W4283791093","https://openalex.org/W4292156489","https://openalex.org/W4308592532","https://openalex.org/W4316654723","https://openalex.org/W4322628436","https://openalex.org/W4324148932","https://openalex.org/W4383534112","https://openalex.org/W4390511101","https://openalex.org/W4396790628","https://openalex.org/W4400692946"],"related_works":["https://openalex.org/W3125058662","https://openalex.org/W31220157","https://openalex.org/W63065332","https://openalex.org/W1990738922","https://openalex.org/W3093365844","https://openalex.org/W2288557197","https://openalex.org/W2983071886","https://openalex.org/W4233024177","https://openalex.org/W397719029","https://openalex.org/W2023538514"],"abstract_inverted_index":{"We":[0],"have":[1,31,109],"analyzed":[2,194],"the":[3,22,48,76,80,83,86,106,117,148,165,169,186,192,197,211,216],"relationship":[4],"between":[5,134,159],"disability":[6],"and":[7,25,55,105,136,155,164,203,207,221],"neck":[8,13,56,151,234],"flexion-extension":[9],"kinematics":[10,235],"in":[11,37,113,182,233],"non-specific":[12],"pain":[14],"subjects.":[15],"A":[16],"functional":[17],"approach":[18],"is":[19],"used":[20,231],"considering":[21],"angle,":[23],"velocity,":[24],"acceleration":[26,156,208,222],"curves.":[27,157,199,209],"Different":[28],"regression":[29],"models":[30],"been":[32,72],"fitted":[33],"for":[34,67,139],"each":[35],"time":[36],"order":[38,114],"to":[39,60,110,115],"obtain":[40],"these":[41],"curves":[42,223],"using":[43,89,168],"scalar":[44],"predictors":[45],"such":[46],"as":[47],"Neck":[49],"Disability":[50],"Index":[51],"(NDI),":[52],"age,":[53],"sex,":[54],"length.":[57],"In":[58,122,200],"addition":[59],"classical":[61],"regression,":[62],"a":[63,101,124,177],"limma":[64,170,183],"(Linear":[65],"Models":[66],"Microarray":[68],"Data)":[69],"model":[70],"has":[71],"used,":[73],"which":[74],"improves":[75],"fit":[77],"by":[78],"modifying":[79],"estimation":[81],"of":[82,85,150,180,191,213],"variances":[84],"different":[87],"fits":[88,167],"an":[90],"empirical":[91],"Bayes":[92],"approach.":[93],"As":[94],"point-by-point":[95],"adjustments":[96],"are":[97,174,188],"performed,":[98],"this":[99],"introduces":[100],"multiple":[102,161],"comparison":[103],"problem,":[104],"corresponding":[107],"p-values":[108,138,181,187,214],"be":[111,230],"adjusted":[112,137],"control":[116],"false":[118],"discovery":[119],"rate":[120],"(FDR).":[121],"particular,":[123],"Benjamini-Hochberg":[125],"method":[126,171],"was":[127],"used.":[128],"The":[129],"results":[130,144],"show":[131],"significant":[132],"differences":[133],"raw":[135],"all":[140],"variables,":[141],"so":[142,227],"spurious":[143],"were":[145],"detected,":[146],"e.g.,":[147],"effect":[149],"length":[152],"on":[153],"velocity":[154,206,220],"Differences":[158],"usual":[160],"linear":[162],"regressions":[163],"modified":[166],"(limma":[172],"models)":[173],"minor,":[175],"with":[176],"slight":[178],"decrement":[179],"models.":[184],"Once":[185],"adjusted,":[189],"none":[190],"variables":[193],"significantly":[195],"affects":[196],"angular":[198],"contrast,":[201],"NDI":[202],"age":[204],"affect":[205],"Furthermore,":[210],"study":[212],"throughout":[215],"movement":[217],"shows":[218],"that":[219],"provide":[224],"complementary":[225],"information,":[226],"they":[228],"should":[229],"together":[232],"studies.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-10-10T00:00:00"}