{"id":"https://openalex.org/W3152897113","doi":"https://doi.org/10.1007/s11517-021-02343-9","title":"Genetic interactions effects for cancer disease identification using computational models: a review","display_name":"Genetic interactions effects for cancer disease identification using computational models: a review","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W3152897113","doi":"https://doi.org/10.1007/s11517-021-02343-9","mag":"3152897113","pmid":"https://pubmed.ncbi.nlm.nih.gov/33839998"},"language":"en","primary_location":{"id":"doi:10.1007/s11517-021-02343-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-021-02343-9","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical &amp; Biological Engineering &amp; Computing","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024287129","display_name":"R. Manavalan","orcid":"https://orcid.org/0000-0002-8683-4692"},"institutions":[{"id":"https://openalex.org/I148776243","display_name":"Government of Tamil Nadu","ror":"https://ror.org/013hg1t45","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"R. Manavalan","raw_affiliation_strings":["Department of Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, 605602, India. manavalan_r@rediffmail.com","Department of Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, 605602, India"],"raw_orcid":"https://orcid.org/0000-0002-8683-4692","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, 605602, India. manavalan_r@rediffmail.com","institution_ids":["https://openalex.org/I148776243"]},{"raw_affiliation_string":"Department of Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, 605602, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060220765","display_name":"S. Priya","orcid":"https://orcid.org/0000-0002-3756-4235"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Priya","raw_affiliation_strings":["Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science, Arignar Anna Government Arts College, Villupuram, Tamil Nadu, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024287129"],"corresponding_institution_ids":["https://openalex.org/I148776243"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.6508,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66386987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"4","first_page":"733","last_page":"758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.7945009469985962},{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.7760421633720398},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6232006549835205},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6149523854255676},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6085006594657898},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5806121230125427},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5185382962226868},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.4739515781402588},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.46698564291000366},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4429788589477539},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3359418213367462},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.26642906665802},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.212001234292984},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20522090792655945},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11704826354980469}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.7945009469985962},{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.7760421633720398},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6232006549835205},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6149523854255676},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6085006594657898},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5806121230125427},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5185382962226868},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4739515781402588},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.46698564291000366},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4429788589477539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3359418213367462},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.26642906665802},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.212001234292984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20522090792655945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11704826354980469},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058011","descriptor_name":"Multifactor Dimensionality Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058011","descriptor_name":"Multifactor Dimensionality Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058011","descriptor_name":"Multifactor Dimensionality Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058011","descriptor_name":"Multifactor Dimensionality Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11517-021-02343-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-021-02343-9","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical &amp; Biological Engineering &amp; Computing","raw_type":"journal-article"},{"id":"pmid:33839998","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33839998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & biological engineering & computing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W160515281","https://openalex.org/W1040906197","https://openalex.org/W1454889412","https://openalex.org/W1480880155","https://openalex.org/W1501108249","https://openalex.org/W1509581215","https://openalex.org/W1868492295","https://openalex.org/W1893995926","https://openalex.org/W1901752173","https://openalex.org/W1963989728","https://openalex.org/W1964866242","https://openalex.org/W1965829087","https://openalex.org/W1971285093","https://openalex.org/W1977494547","https://openalex.org/W1979749491","https://openalex.org/W1982195004","https://openalex.org/W1994414574","https://openalex.org/W1999819760","https://openalex.org/W2013789968","https://openalex.org/W2016138806","https://openalex.org/W2016645182","https://openalex.org/W2023785540","https://openalex.org/W2028689806","https://openalex.org/W2030628077","https://openalex.org/W2032180763","https://openalex.org/W2041713290","https://openalex.org/W2052182252","https://openalex.org/W2056989424","https://openalex.org/W2057473493","https://openalex.org/W2060533205","https://openalex.org/W2060849473","https://openalex.org/W2064539914","https://openalex.org/W2076220518","https://openalex.org/W2077698649","https://openalex.org/W2086482109","https://openalex.org/W2087510781","https://openalex.org/W2092218554","https://openalex.org/W2092366795","https://openalex.org/W2099329054","https://openalex.org/W2104549677","https://openalex.org/W2104605543","https://openalex.org/W2107916366","https://openalex.org/W2110998362","https://openalex.org/W2114203843","https://openalex.org/W2117138514","https://openalex.org/W2118889842","https://openalex.org/W2120233948","https://openalex.org/W2125158282","https://openalex.org/W2130297133","https://openalex.org/W2130442383","https://openalex.org/W2133298971","https://openalex.org/W2134386780","https://openalex.org/W2140501130","https://openalex.org/W2140841754","https://openalex.org/W2141004317","https://openalex.org/W2145033566","https://openalex.org/W2146195132","https://openalex.org/W2154427268","https://openalex.org/W2154572047","https://openalex.org/W2163012157","https://openalex.org/W2163924952","https://openalex.org/W2177211260","https://openalex.org/W2196666986","https://openalex.org/W2209093312","https://openalex.org/W2214536576","https://openalex.org/W2222833576","https://openalex.org/W2257413528","https://openalex.org/W2285056512","https://openalex.org/W2319197375","https://openalex.org/W2333063602","https://openalex.org/W2345077773","https://openalex.org/W2345128305","https://openalex.org/W2384430383","https://openalex.org/W2405013394","https://openalex.org/W2460953563","https://openalex.org/W2504552073","https://openalex.org/W2519744449","https://openalex.org/W2531971686","https://openalex.org/W2547574709","https://openalex.org/W2565388408","https://openalex.org/W2576034892","https://openalex.org/W2602751862","https://openalex.org/W2618454934","https://openalex.org/W2621428960","https://openalex.org/W2725988230","https://openalex.org/W2761518648","https://openalex.org/W2766560177","https://openalex.org/W2770902446","https://openalex.org/W2781587526","https://openalex.org/W2784112514","https://openalex.org/W2790914193","https://openalex.org/W2799505282","https://openalex.org/W2809314951","https://openalex.org/W2809727192","https://openalex.org/W2886879342","https://openalex.org/W2887089397","https://openalex.org/W2894930578","https://openalex.org/W2895756362","https://openalex.org/W2896975075","https://openalex.org/W2898507031","https://openalex.org/W2898780495","https://openalex.org/W2912174629","https://openalex.org/W2920486402","https://openalex.org/W2921884745","https://openalex.org/W2939295728","https://openalex.org/W2945103729","https://openalex.org/W2952522477","https://openalex.org/W2971857600","https://openalex.org/W2977390077","https://openalex.org/W2981345363","https://openalex.org/W2988685366","https://openalex.org/W2996507122","https://openalex.org/W3008589258","https://openalex.org/W3021516242","https://openalex.org/W3022145914","https://openalex.org/W3024698098","https://openalex.org/W3035860719","https://openalex.org/W3036563019","https://openalex.org/W3040781166","https://openalex.org/W3042451765","https://openalex.org/W3048156034","https://openalex.org/W3085619331","https://openalex.org/W3090906905","https://openalex.org/W4249493736","https://openalex.org/W4386941397"],"related_works":["https://openalex.org/W1988072872","https://openalex.org/W3150638776","https://openalex.org/W2113244577","https://openalex.org/W4393427313","https://openalex.org/W2416919291","https://openalex.org/W2162555644","https://openalex.org/W4213127452","https://openalex.org/W1996840382","https://openalex.org/W2140140747","https://openalex.org/W2402496592"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
