{"id":"https://openalex.org/W2613401742","doi":"https://doi.org/10.1007/s11517-017-1650-x","title":"Insights from mathematical modeling for convection-enhanced intraputamenal delivery of GDNF","display_name":"Insights from mathematical modeling for convection-enhanced intraputamenal delivery of GDNF","publication_year":2017,"publication_date":"2017-05-11","ids":{"openalex":"https://openalex.org/W2613401742","doi":"https://doi.org/10.1007/s11517-017-1650-x","mag":"2613401742","pmid":"https://pubmed.ncbi.nlm.nih.gov/28493093"},"language":"en","primary_location":{"id":"doi:10.1007/s11517-017-1650-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-017-1650-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11517-017-1650-x.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical &amp; Biological Engineering &amp; Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs11517-017-1650-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102901338","display_name":"\u0415\u043b\u0435\u043d\u0430 \u0411\u0435\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-2663-5963"},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elena Belova","raw_affiliation_strings":["Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA. elena.belova@pfizer.com","Worldwide Research & Development, Pfizer Inc., Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA. elena.belova@pfizer.com","institution_ids":[]},{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., Cambridge, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051900776","display_name":"Christopher L. Shaffer","orcid":"https://orcid.org/0000-0002-7927-4914"},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Shaffer","raw_affiliation_strings":["Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA","Worldwide Research & Development, Pfizer Inc., Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., Cambridge, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069822265","display_name":"Patrick Trapa","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick E. Trapa","raw_affiliation_strings":["Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA","Worldwide Research & Development, Pfizer Inc., Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., 1 Portland Street, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Worldwide Research & Development, Pfizer Inc., Cambridge, USA","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102901338"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":{"value":2890,"currency":"EUR","value_usd":3690},"fwci":0.4774,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5665185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"55","issue":"12","first_page":"2069","last_page":"2077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"Glial cell line-derived neurotrophic factor","score":0.9765254259109497},{"id":"https://openalex.org/keywords/putamen","display_name":"Putamen","score":0.8569984436035156},{"id":"https://openalex.org/keywords/striatum","display_name":"Striatum","score":0.6817246675491333},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"Neurotrophic factors","score":0.6259580850601196},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5459162592887878},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.5077146291732788},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.46586135029792786},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.44160526990890503},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4011850357055664},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.33559727668762207},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3272453248500824},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3208855092525482},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32012370228767395},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27760666608810425},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1497844159603119},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.1080000102519989},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09197628498077393}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.9765254259109497},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.8569984436035156},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6817246675491333},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6259580850601196},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5459162592887878},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5077146291732788},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46586135029792786},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.44160526990890503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4011850357055664},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.33559727668762207},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3272453248500824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3208855092525482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32012370228767395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27760666608810425},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1497844159603119},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1080000102519989},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09197628498077393},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11517-017-1650-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-017-1650-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11517-017-1650-x.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical &amp; Biological Engineering &amp; Computing","raw_type":"journal-article"},{"id":"pmid:28493093","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28493093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & biological engineering & computing","raw_type":null},{"id":"pmh:oai:europepmc.org:4607304","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680405","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s11517-017-1650-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-017-1650-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11517-017-1650-x.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical &amp; Biological Engineering &amp; Computing","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2613401742.pdf","grobid_xml":"https://content.openalex.org/works/W2613401742.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1548125226","https://openalex.org/W1967089865","https://openalex.org/W1970043864","https://openalex.org/W1971258758","https://openalex.org/W1971286044","https://openalex.org/W1974726724","https://openalex.org/W1991208841","https://openalex.org/W1996001296","https://openalex.org/W1999128801","https://openalex.org/W2013166662","https://openalex.org/W2019695510","https://openalex.org/W2023307923","https://openalex.org/W2032554568","https://openalex.org/W2040344246","https://openalex.org/W2040880670","https://openalex.org/W2048303811","https://openalex.org/W2054810445","https://openalex.org/W2063553747","https://openalex.org/W2063893203","https://openalex.org/W2074432223","https://openalex.org/W2082870228","https://openalex.org/W2094061170","https://openalex.org/W2103899142","https://openalex.org/W2106495485","https://openalex.org/W2123363285","https://openalex.org/W2135062838","https://openalex.org/W2165526364","https://openalex.org/W2178835613","https://openalex.org/W2187658776","https://openalex.org/W2280420202","https://openalex.org/W2481475898","https://openalex.org/W4233946123"],"related_works":["https://openalex.org/W1979374156","https://openalex.org/W2346430935","https://openalex.org/W2063893203","https://openalex.org/W3024236120","https://openalex.org/W2063640110","https://openalex.org/W3085831639","https://openalex.org/W2785262129","https://openalex.org/W797812918","https://openalex.org/W2381823432","https://openalex.org/W2079883031"],"abstract_inverted_index":{"Glial":[0],"cell":[1],"line-derived":[2],"neurotrophic":[3],"factor":[4],"(GDNF)":[5],"is":[6,178],"a":[7,37,89,130,153,184],"potential":[8],"therapy":[9],"for":[10],"Parkinson's":[11],"disease":[12],"(PD)":[13],"promoting":[14],"survival":[15],"and":[16,75,107,129,158],"functional":[17],"recovery":[18],"of":[19,32,35,40,58,78,84,93,105,114,124,140,163,173,186],"dopaminergic":[20],"neurons":[21],"when":[22],"delivered":[23],"to":[24,65,82,121,135,180],"the":[25,30,48,85,94,122,125,159,176],"degenerated":[26],"striatum.":[27],"To":[28],"study":[29],"aspects":[31],"intraputamenal":[33],"delivery":[34,56],"GDNF,":[36],"mathematical":[38],"model":[39],"recombinant":[41],"methionyl":[42],"human":[43,49],"GDNF":[44,115,164,174],"(r-metHuGDNF)":[45],"convection":[46],"in":[47,100,119,155],"putamen":[50],"has":[51],"been":[52],"developed.":[53],"The":[54,68,112,171],"convection-enhanced":[55],"infusions":[57,70],"r-metHuGDNF":[59],"were":[60,110,117],"simulated":[61],"at":[62,102],"rates":[63,104],"up":[64,81],"5":[66,108],"\u03bcL/min.":[67],"high-rate":[69],"(\u22651":[71],"\u03bcL/min)":[72],"permit":[73],"rapid":[74],"uniform":[76],"distribution":[77,86,101,116,165],"drug":[79],"with":[80,183],"75%":[83],"volume":[87],"having":[88],"concentration":[90],"within":[91],"5%":[92],"infusate":[95],"concentration.":[96],"No":[97],"relevant":[98],"differences":[99],"infusion":[103],"3":[106],"\u03bcL/min":[109],"found.":[111],"patterns":[113],"analyzed":[118],"relation":[120],"anatomy":[123],"posterior":[126],"dorsal":[127],"putamen,":[128],"cylindrical":[131],"shape":[132],"was":[133,150,166],"found":[134],"be":[136,181],"preferable":[137],"considering":[138],"risks":[139],"target":[141],"overflow.":[142],"A":[143],"magnetic":[144],"resonance":[145],"(MR)":[146],"tracer":[147],"Gd-DTPA":[148],"(Magnevist\u00ae)":[149],"evaluated":[151],"as":[152],"surrogate":[154],"clinical":[156],"studies,":[157],"most":[160],"accurate":[161],"prediction":[162],"calculated":[167],"immediately":[168],"after":[169],"infusion.":[170],"clearance":[172],"from":[175],"striatum":[177],"confirmed":[179],"slow,":[182],"half-life":[185],"ca.":[187],"19":[188],"h.":[189]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
