{"id":"https://openalex.org/W2081310581","doi":"https://doi.org/10.1007/s11517-011-0844-x","title":"Strategy for NSAID administration to aspirin-intolerant asthmatics in combination with PGE2 analogue: a theoretical approach","display_name":"Strategy for NSAID administration to aspirin-intolerant asthmatics in combination with PGE2 analogue: a theoretical approach","publication_year":2011,"publication_date":"2011-11-25","ids":{"openalex":"https://openalex.org/W2081310581","doi":"https://doi.org/10.1007/s11517-011-0844-x","mag":"2081310581","pmid":"https://pubmed.ncbi.nlm.nih.gov/22120424"},"language":"en","primary_location":{"id":"doi:10.1007/s11517-011-0844-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-011-0844-x","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064750987","display_name":"Andrej Dobovi\u0161ek","orcid":null},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"A. Dobovi\u0161ek","raw_affiliation_strings":["Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia. andrej.dobovisek@uni-mb.si","Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia"],"affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia. andrej.dobovisek@uni-mb.si","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064887279","display_name":"Ale\u0161 Fajmut","orcid":"https://orcid.org/0000-0003-4418-983X"},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"A. Fajmut","raw_affiliation_strings":["Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Slom\u0161kov trg 15, 2000, Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia"],"affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Slom\u0161kov trg 15, 2000, Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070734938","display_name":"Milan Brumen","orcid":null},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]},{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"M. Brumen","raw_affiliation_strings":["Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Slom\u0161kov trg 15, 2000, Maribor, Slovenia","Institute Jo\u017eef Stefan, Jamova cesta 39, 1000, Ljubljana, Slovenia","Institute Jo\u017eef Stefan, Ljubljana, Slovenia","Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia"],"affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Slom\u0161kov trg 15, 2000, Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Institute Jo\u017eef Stefan, Jamova cesta 39, 1000, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]},{"raw_affiliation_string":"Institute Jo\u017eef Stefan, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, Faculty of Medicine, Faculty of Health Sciences, University of Maribor, Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064750987"],"corresponding_institution_ids":["https://openalex.org/I37696226"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.5418,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71974381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"50","issue":"1","first_page":"33","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"Ibuprofen","score":0.9688519835472107},{"id":"https://openalex.org/keywords/aspirin","display_name":"Aspirin","score":0.9538684487342834},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7359741926193237},{"id":"https://openalex.org/keywords/ingestion","display_name":"Ingestion","score":0.6232828497886658},{"id":"https://openalex.org/keywords/antipyretic","display_name":"Antipyretic","score":0.5962625741958618},{"id":"https://openalex.org/keywords/asthma","display_name":"Asthma","score":0.5801444053649902},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5100629925727844},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5060133337974548},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.46901434659957886},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.4660094380378723},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.3699870705604553},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.283468097448349},{"id":"https://openalex.org/keywords/analgesic","display_name":"Analgesic","score":0.2123640775680542}],"concepts":[{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.9688519835472107},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9538684487342834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7359741926193237},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6232828497886658},{"id":"https://openalex.org/C2779252780","wikidata":"https://www.wikidata.org/wiki/Q582687","display_name":"Antipyretic","level":3,"score":0.5962625741958618},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5801444053649902},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5100629925727844},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5060133337974548},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.46901434659957886},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4660094380378723},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3699870705604553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.283468097448349},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.2123640775680542},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D055963","descriptor_name":"Asthma, Aspirin-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D055963","descriptor_name":"Asthma, Aspirin-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D055963","descriptor_name":"Asthma, Aspirin-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11517-011-0844-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-011-0844-x","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},{"id":"pmid:22120424","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22120424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & biological engineering & computing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W197791659","https://openalex.org/W1480692184","https://openalex.org/W1484198052","https://openalex.org/W1536681507","https://openalex.org/W1870315080","https://openalex.org/W1976384048","https://openalex.org/W1980545986","https://openalex.org/W1986420435","https://openalex.org/W1986781993","https://openalex.org/W2001033420","https://openalex.org/W2003251689","https://openalex.org/W2008757484","https://openalex.org/W2019119600","https://openalex.org/W2029765423","https://openalex.org/W2038199642","https://openalex.org/W2061592031","https://openalex.org/W2067253726","https://openalex.org/W2069597374","https://openalex.org/W2077860496","https://openalex.org/W2079782583","https://openalex.org/W2086309760","https://openalex.org/W2111370401","https://openalex.org/W2128457170","https://openalex.org/W2131296354","https://openalex.org/W2134783974","https://openalex.org/W2137027350","https://openalex.org/W2144888331","https://openalex.org/W2150978627","https://openalex.org/W2157532035","https://openalex.org/W2160363614","https://openalex.org/W4238726034"],"related_works":["https://openalex.org/W1908376293","https://openalex.org/W2108707538","https://openalex.org/W1986665418","https://openalex.org/W4237459359","https://openalex.org/W2019987535","https://openalex.org/W2296515940","https://openalex.org/W2165926287","https://openalex.org/W4243712096","https://openalex.org/W2063401681","https://openalex.org/W205180216"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}