{"id":"https://openalex.org/W2029870933","doi":"https://doi.org/10.1007/s11517-009-0449-9","title":"Multi-scale modeling of the human cardiovascular system with applications to aortic valvular and arterial stenoses","display_name":"Multi-scale modeling of the human cardiovascular system with applications to aortic valvular and arterial stenoses","publication_year":2009,"publication_date":"2009-02-07","ids":{"openalex":"https://openalex.org/W2029870933","doi":"https://doi.org/10.1007/s11517-009-0449-9","mag":"2029870933","pmid":"https://pubmed.ncbi.nlm.nih.gov/19198911"},"language":"en","primary_location":{"id":"doi:10.1007/s11517-009-0449-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-009-0449-9","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029159076","display_name":"Fuyou Liang","orcid":"https://orcid.org/0000-0001-5012-486X"},"institutions":[{"id":"https://openalex.org/I4210129730","display_name":"RIKEN Center for Computational Science","ror":"https://ror.org/03r519674","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210129730"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fuyou Liang","raw_affiliation_strings":["Computational Science Research Program, RIKEN, Wako, Saitama, Japan","Computational Science Research Program, RIKEN, Wako, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Saitama, Japan","institution_ids":["https://openalex.org/I4210129730"]},{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Japan","institution_ids":["https://openalex.org/I4210129730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047168031","display_name":"Shu Takagi","orcid":"https://orcid.org/0000-0002-9353-2465"},"institutions":[{"id":"https://openalex.org/I4210129730","display_name":"RIKEN Center for Computational Science","ror":"https://ror.org/03r519674","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210129730"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shu Takagi","raw_affiliation_strings":["Computational Science Research Program, RIKEN, Wako, Saitama, Japan","Computational Science Research Program, RIKEN, Wako, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Saitama, Japan","institution_ids":["https://openalex.org/I4210129730"]},{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Japan","institution_ids":["https://openalex.org/I4210129730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091251386","display_name":"Ryutaro Himeno","orcid":"https://orcid.org/0000-0003-3378-6989"},"institutions":[{"id":"https://openalex.org/I4210129730","display_name":"RIKEN Center for Computational Science","ror":"https://ror.org/03r519674","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210129730"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryutaro Himeno","raw_affiliation_strings":["Computational Science Research Program, RIKEN, Wako, Saitama, Japan","Computational Science Research Program, RIKEN, Wako, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Saitama, Japan","institution_ids":["https://openalex.org/I4210129730"]},{"raw_affiliation_string":"Computational Science Research Program, RIKEN, Wako, Japan","institution_ids":["https://openalex.org/I4210129730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100659985","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0002-8687-3237"},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Graduate School of Engineering, Chiba University, Chiba-Shi, Chiba, Japan","Graduate School of Engineering, Chiba University, Chiba-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Chiba University, Chiba-Shi, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Graduate School of Engineering, Chiba University, Chiba-shi, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047168031"],"corresponding_institution_ids":["https://openalex.org/I4210129730"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":3.2767,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.9256568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"47","issue":"7","first_page":"743","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.8524291515350342},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6819810271263123},{"id":"https://openalex.org/keywords/arterial-tree","display_name":"Arterial tree","score":0.6569448113441467},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6115965247154236},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5253205299377441},{"id":"https://openalex.org/keywords/aortic-pressure","display_name":"Aortic pressure","score":0.49428701400756836},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.4660177528858185}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.8524291515350342},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6819810271263123},{"id":"https://openalex.org/C2776619873","wikidata":"https://www.wikidata.org/wiki/Q3623006","display_name":"Arterial tree","level":2,"score":0.6569448113441467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6115965247154236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5253205299377441},{"id":"https://openalex.org/C39124391","wikidata":"https://www.wikidata.org/wiki/Q4778759","display_name":"Aortic pressure","level":3,"score":0.49428701400756836},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4660177528858185}],"mesh":[{"descriptor_ui":"D001018","descriptor_name":"Aortic Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001018","descriptor_name":"Aortic Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001018","descriptor_name":"Aortic Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11517-009-0449-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11517-009-0449-9","pdf_url":null,"source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & Biological Engineering & Computing","raw_type":"journal-article"},{"id":"pmid:19198911","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19198911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical & biological engineering & computing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1976047074","https://openalex.org/W1983692570","https://openalex.org/W1990451556","https://openalex.org/W1995665182","https://openalex.org/W2000523039","https://openalex.org/W2002775075","https://openalex.org/W2017221385","https://openalex.org/W2021653731","https://openalex.org/W2030159115","https://openalex.org/W2034444616","https://openalex.org/W2036745273","https://openalex.org/W2041472716","https://openalex.org/W2046037710","https://openalex.org/W2050752656","https://openalex.org/W2052801507","https://openalex.org/W2054247732","https://openalex.org/W2067892614","https://openalex.org/W2086107612","https://openalex.org/W2086799842","https://openalex.org/W2096468939","https://openalex.org/W2103819289","https://openalex.org/W2104408488","https://openalex.org/W2106589350","https://openalex.org/W2119132351","https://openalex.org/W2125183359","https://openalex.org/W2141016333","https://openalex.org/W2144858365","https://openalex.org/W2145386104","https://openalex.org/W2145541448","https://openalex.org/W2145950740","https://openalex.org/W2172213190","https://openalex.org/W2230543618","https://openalex.org/W2296738110","https://openalex.org/W2474088718","https://openalex.org/W2586665497"],"related_works":["https://openalex.org/W2029870933","https://openalex.org/W2133924221","https://openalex.org/W1919354868","https://openalex.org/W2264046868","https://openalex.org/W2167180135","https://openalex.org/W2132276717","https://openalex.org/W2120714791","https://openalex.org/W2222166273","https://openalex.org/W52136443","https://openalex.org/W2275892966"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}