{"id":"https://openalex.org/W3155115410","doi":"https://doi.org/10.1007/s11222-021-10010-0","title":"A fast and efficient smoothing approach to Lasso regression and an application in statistical genetics: polygenic risk scores for chronic obstructive pulmonary disease (COPD)","display_name":"A fast and efficient smoothing approach to Lasso regression and an application in statistical genetics: polygenic risk scores for chronic obstructive pulmonary disease (COPD)","publication_year":2021,"publication_date":"2021-04-17","ids":{"openalex":"https://openalex.org/W3155115410","doi":"https://doi.org/10.1007/s11222-021-10010-0","mag":"3155115410"},"language":"en","primary_location":{"id":"doi:10.1007/s11222-021-10010-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11222-021-10010-0","pdf_url":null,"source":{"id":"https://openalex.org/S5437875","display_name":"Statistics and Computing","issn_l":"0960-3174","issn":["0960-3174","1573-1375"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics and Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010215905","display_name":"Georg Hahn","orcid":"https://orcid.org/0000-0001-6008-2720"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Georg Hahn","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051019541","display_name":"Sharon M. Lutz","orcid":"https://orcid.org/0000-0002-1515-9431"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon M. Lutz","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049455009","display_name":"Nilanjana Laha","orcid":"https://orcid.org/0000-0002-1335-2422"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilanjana Laha","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018495347","display_name":"Michael H. Cho","orcid":"https://orcid.org/0000-0002-4907-1657"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Cho","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K. Silverman","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002736890","display_name":"Christoph Lange","orcid":"https://orcid.org/0000-0003-2620-1030"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Lange","raw_affiliation_strings":["Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA"],"affiliations":[{"raw_affiliation_string":"Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010215905"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":2090,"currency":"EUR","value_usd":2690},"apc_paid":null,"fwci":0.946,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76736852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.8377134799957275},{"id":"https://openalex.org/keywords/smoothing","display_name":"Smoothing","score":0.6218369603157043},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4932710528373718},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4565041661262512},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4537421464920044},{"id":"https://openalex.org/keywords/convexity","display_name":"Convexity","score":0.44669482111930847},{"id":"https://openalex.org/keywords/gradient-descent","display_name":"Gradient descent","score":0.4309741258621216},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.4270840287208557},{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.41728609800338745},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3684611916542053},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3455308973789215},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.290728896856308},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2316558063030243},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22275382280349731},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.21142077445983887},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.19204285740852356},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10579299926757812},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.09828633069992065}],"concepts":[{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.8377134799957275},{"id":"https://openalex.org/C3770464","wikidata":"https://www.wikidata.org/wiki/Q775963","display_name":"Smoothing","level":2,"score":0.6218369603157043},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4932710528373718},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4565041661262512},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4537421464920044},{"id":"https://openalex.org/C72134830","wikidata":"https://www.wikidata.org/wiki/Q5166524","display_name":"Convexity","level":2,"score":0.44669482111930847},{"id":"https://openalex.org/C153258448","wikidata":"https://www.wikidata.org/wiki/Q1199743","display_name":"Gradient descent","level":3,"score":0.4309741258621216},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.4270840287208557},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.41728609800338745},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3684611916542053},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3455308973789215},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.290728896856308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2316558063030243},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22275382280349731},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.21142077445983887},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.19204285740852356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10579299926757812},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09828633069992065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11222-021-10010-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11222-021-10010-0","pdf_url":null,"source":{"id":"https://openalex.org/S5437875","display_name":"Statistics and Computing","issn_l":"0960-3174","issn":["0960-3174","1573-1375"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics and Computing","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G5186837181","display_name":null,"funder_award_id":"P01HL120839","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G744216480","display_name":null,"funder_award_id":"R01HG008976","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7969315294","display_name":null,"funder_award_id":"P01HL132825","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2056385679","https://openalex.org/W2063978378","https://openalex.org/W2074682976","https://openalex.org/W2082907106","https://openalex.org/W2097360283","https://openalex.org/W2100556411","https://openalex.org/W2115706991","https://openalex.org/W2122189635","https://openalex.org/W2135046866","https://openalex.org/W2167732364","https://openalex.org/W2613151407","https://openalex.org/W2886752110","https://openalex.org/W2936995161","https://openalex.org/W3088366695","https://openalex.org/W4294541781","https://openalex.org/W4399550443"],"related_works":["https://openalex.org/W2985746494","https://openalex.org/W4206042385","https://openalex.org/W1964872188","https://openalex.org/W2511384863","https://openalex.org/W2096089271","https://openalex.org/W2923628599","https://openalex.org/W2014100433","https://openalex.org/W2051519658","https://openalex.org/W128985311","https://openalex.org/W4205405116"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
