{"id":"https://openalex.org/W4409952638","doi":"https://doi.org/10.1007/s10916-025-02190-3","title":"Predicting Visual Acuity after Retinal Vein Occlusion Anti-VEGF Treatment: Development and Validation of an Interpretable Machine Learning Model","display_name":"Predicting Visual Acuity after Retinal Vein Occlusion Anti-VEGF Treatment: Development and Validation of an Interpretable Machine Learning Model","publication_year":2025,"publication_date":"2025-04-29","ids":{"openalex":"https://openalex.org/W4409952638","doi":"https://doi.org/10.1007/s10916-025-02190-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40299116"},"language":"en","primary_location":{"id":"doi:10.1007/s10916-025-02190-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10916-025-02190-3","pdf_url":null,"source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047395054","display_name":"Chunlan Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunlan Liang","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110011018","display_name":"Lian Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Liu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056193097","display_name":"Tong Zhao","orcid":"https://orcid.org/0000-0002-9517-3240"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianqi Zhao","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031999615","display_name":"Wei Ouyang","orcid":"https://orcid.org/0000-0002-5851-056X"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyun Ouyang","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048536322","display_name":"Guocheng Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guocheng Yu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108108136","display_name":"J Lyu","orcid":"https://orcid.org/0009-0002-6754-4371"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Lyu","raw_affiliation_strings":["Department of Clinical Research, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China. lyujun2020@jnu.edu.cn"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China. lyujun2020@jnu.edu.cn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100351577","display_name":"Jingxiang Zhong","orcid":"https://orcid.org/0000-0002-5774-7602"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingxiang Zhong","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China. zjx85221206@126.com"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China. zjx85221206@126.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047395054"],"corresponding_institution_ids":["https://openalex.org/I4210162753"],"apc_list":{"value":3390,"currency":"EUR","value_usd":4390},"apc_paid":null,"fwci":16.6475,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.99279845,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"49","issue":"1","first_page":"57","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-vein","display_name":"Retinal Vein","score":0.7528842687606812},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"Visual acuity","score":0.7098968029022217},{"id":"https://openalex.org/keywords/occlusion","display_name":"Occlusion","score":0.59415602684021},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5773210525512695},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.5389286875724792},{"id":"https://openalex.org/keywords/central-retinal-vein-occlusion","display_name":"Central retinal vein occlusion","score":0.5219423174858093},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4752854108810425},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.458948016166687},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4512665271759033},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.348497211933136},{"id":"https://openalex.org/keywords/macular-edema","display_name":"Macular edema","score":0.19703558087348938},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.16676339507102966},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10361900925636292},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.06354808807373047}],"concepts":[{"id":"https://openalex.org/C2908732032","wikidata":"https://www.wikidata.org/wiki/Q5062148","display_name":"Retinal Vein","level":3,"score":0.7528842687606812},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.7098968029022217},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.59415602684021},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5773210525512695},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5389286875724792},{"id":"https://openalex.org/C2778844676","wikidata":"https://www.wikidata.org/wiki/Q190831","display_name":"Central retinal vein occlusion","level":4,"score":0.5219423174858093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4752854108810425},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.458948016166687},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4512665271759033},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.348497211933136},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.19703558087348938},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16676339507102966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10361900925636292},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.06354808807373047}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10916-025-02190-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10916-025-02190-3","pdf_url":null,"source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},{"id":"pmid:40299116","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40299116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[{"id":"https://openalex.org/G853043449","display_name":null,"funder_award_id":"82271094","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1512221254","https://openalex.org/W1586376915","https://openalex.org/W1588739914","https://openalex.org/W1822338637","https://openalex.org/W1968708116","https://openalex.org/W1991439648","https://openalex.org/W2082817605","https://openalex.org/W2090342619","https://openalex.org/W2166339706","https://openalex.org/W2254249950","https://openalex.org/W2507380695","https://openalex.org/W2509519298","https://openalex.org/W2523034663","https://openalex.org/W2605591250","https://openalex.org/W2610406128","https://openalex.org/W2765355977","https://openalex.org/W2770650418","https://openalex.org/W2885342691","https://openalex.org/W2897831960","https://openalex.org/W2898007984","https://openalex.org/W2964087216","https://openalex.org/W2975636469","https://openalex.org/W2976285307","https://openalex.org/W2995847122","https://openalex.org/W3018708616","https://openalex.org/W3088311734","https://openalex.org/W3093671505","https://openalex.org/W3094869231","https://openalex.org/W3111867831","https://openalex.org/W3134784484","https://openalex.org/W3147809485","https://openalex.org/W3162544636","https://openalex.org/W3172509608","https://openalex.org/W3182032140","https://openalex.org/W3216962415","https://openalex.org/W4231930751","https://openalex.org/W4235001346","https://openalex.org/W4283819402","https://openalex.org/W4304786594","https://openalex.org/W4306158199","https://openalex.org/W4307814854","https://openalex.org/W4318708284","https://openalex.org/W4360601249","https://openalex.org/W4386552939","https://openalex.org/W4386752329","https://openalex.org/W4386817963","https://openalex.org/W4387336518","https://openalex.org/W4388302825","https://openalex.org/W4391798186","https://openalex.org/W4392163013","https://openalex.org/W4400672891","https://openalex.org/W4401378531","https://openalex.org/W4402441278","https://openalex.org/W4402941821","https://openalex.org/W4403583234","https://openalex.org/W4404106620"],"related_works":["https://openalex.org/W2382115125","https://openalex.org/W185216791","https://openalex.org/W2802474271","https://openalex.org/W1979434163","https://openalex.org/W1160629858","https://openalex.org/W4250948358","https://openalex.org/W4365811185","https://openalex.org/W2081464677","https://openalex.org/W4233779206","https://openalex.org/W4390665542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}