{"id":"https://openalex.org/W4409343862","doi":"https://doi.org/10.1007/s10916-025-02182-3","title":"MLG2Net: Molecular Global Graph Network for Drug Response Prediction in Lung Cancer Cell Lines","display_name":"MLG2Net: Molecular Global Graph Network for Drug Response Prediction in Lung Cancer Cell Lines","publication_year":2025,"publication_date":"2025-04-10","ids":{"openalex":"https://openalex.org/W4409343862","doi":"https://doi.org/10.1007/s10916-025-02182-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40208442"},"language":"en","primary_location":{"id":"doi:10.1007/s10916-025-02182-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10916-025-02182-3","pdf_url":null,"source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054260359","display_name":"Thi-Oanh Tran","orcid":"https://orcid.org/0000-0001-7077-5627"},"institutions":[{"id":"https://openalex.org/I4210152634","display_name":"B\u1ea1ch Mai Hospital","ror":"https://ror.org/05ecec111","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210152634"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW","VN"],"is_corresponding":true,"raw_author_name":"Thi-Oanh Tran","raw_affiliation_strings":["AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam","institution_ids":["https://openalex.org/I4210152634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103260009","display_name":"Thanh-Huy Nguyen","orcid":"https://orcid.org/0009-0003-9355-5434"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I47807185","display_name":"Saigon University","ror":"https://ror.org/01f1fsr30","country_code":"VN","type":"education","lineage":["https://openalex.org/I47807185"]},{"id":"https://openalex.org/I267427436","display_name":"Saigon Technology University","ror":"https://ror.org/044r99091","country_code":"VN","type":"education","lineage":["https://openalex.org/I267427436"]},{"id":"https://openalex.org/I4210152634","display_name":"B\u1ea1ch Mai Hospital","ror":"https://ror.org/05ecec111","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210152634"]}],"countries":["TW","VN"],"is_corresponding":false,"raw_author_name":"Thanh-Huy Nguyen","raw_affiliation_strings":["AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam","Saigon Precision Medicine Research Center, Ho Chi Minh city, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam","institution_ids":["https://openalex.org/I4210152634"]},{"raw_affiliation_string":"Saigon Precision Medicine Research Center, Ho Chi Minh city, Vietnam","institution_ids":["https://openalex.org/I47807185","https://openalex.org/I267427436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052961020","display_name":"Tuan Tung Nguyen","orcid":"https://orcid.org/0000-0002-5322-1523"},"institutions":[{"id":"https://openalex.org/I267427436","display_name":"Saigon Technology University","ror":"https://ror.org/044r99091","country_code":"VN","type":"education","lineage":["https://openalex.org/I267427436"]},{"id":"https://openalex.org/I47807185","display_name":"Saigon University","ror":"https://ror.org/01f1fsr30","country_code":"VN","type":"education","lineage":["https://openalex.org/I47807185"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I4210152634","display_name":"B\u1ea1ch Mai Hospital","ror":"https://ror.org/05ecec111","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210152634"]}],"countries":["TW","VN"],"is_corresponding":false,"raw_author_name":"Tuan Tung Nguyen","raw_affiliation_strings":["AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam","Saigon Precision Medicine Research Center, Ho Chi Minh city, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Hematology and Blood Transfusion Center, Bach Mai Hospital, Hanoi, Viet Nam","institution_ids":["https://openalex.org/I4210152634"]},{"raw_affiliation_string":"Saigon Precision Medicine Research Center, Ho Chi Minh city, Vietnam","institution_ids":["https://openalex.org/I47807185","https://openalex.org/I267427436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014666022","display_name":"Nguyen Quoc Khanh Le","orcid":"https://orcid.org/0009-0008-5888-0932"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nguyen Quoc Khanh Le","raw_affiliation_strings":["AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw","In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw","Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIBioMed Research Group, Taipei Medical University, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw","institution_ids":[]},{"raw_affiliation_string":"In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw","institution_ids":[]},{"raw_affiliation_string":"Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. khanhlee@tmu.edu.tw","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054260359"],"corresponding_institution_ids":["https://openalex.org/I4210152634","https://openalex.org/I47519274"],"apc_list":{"value":3390,"currency":"EUR","value_usd":4390},"apc_paid":null,"fwci":12.1706,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.98663743,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"49","issue":"1","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9775999784469604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6640366911888123},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5613569021224976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48950350284576416},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.4854500889778137},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.45928525924682617},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.43655824661254883},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30153757333755493},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.18044009804725647},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.1654697060585022},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.13017511367797852},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.10912647843360901},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08321177959442139}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6640366911888123},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5613569021224976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48950350284576416},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4854500889778137},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45928525924682617},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.43655824661254883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30153757333755493},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.18044009804725647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.1654697060585022},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.13017511367797852},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10912647843360901},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08321177959442139}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10916-025-02182-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10916-025-02182-3","pdf_url":null,"source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},{"id":"pmid:40208442","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40208442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G8643468963","display_name":null,"funder_award_id":"MOST111-2628-E-038-002-MY3","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"}],"funders":[{"id":"https://openalex.org/F2461203286","display_name":"National Science and Technology Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2043398720","https://openalex.org/W2091091750","https://openalex.org/W2098156682","https://openalex.org/W2108068107","https://openalex.org/W2220553089","https://openalex.org/W2759360483","https://openalex.org/W2767186676","https://openalex.org/W2807463161","https://openalex.org/W2921800758","https://openalex.org/W2946834067","https://openalex.org/W3000469142","https://openalex.org/W3034878304","https://openalex.org/W3080579929","https://openalex.org/W3082081167","https://openalex.org/W3094253649","https://openalex.org/W3096561213","https://openalex.org/W3130891725","https://openalex.org/W3139532774","https://openalex.org/W3154648057","https://openalex.org/W3191852652","https://openalex.org/W3198655865","https://openalex.org/W3203480730","https://openalex.org/W4212847239","https://openalex.org/W4297138475","https://openalex.org/W4310014465","https://openalex.org/W4315754639","https://openalex.org/W4381149253","https://openalex.org/W4387241333","https://openalex.org/W4401937236"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W4206379684","https://openalex.org/W4409308761","https://openalex.org/W2376385980","https://openalex.org/W2967366602","https://openalex.org/W1496498748","https://openalex.org/W2129774558","https://openalex.org/W1997032381","https://openalex.org/W1979593122","https://openalex.org/W1997438133"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}