{"id":"https://openalex.org/W3129911909","doi":"https://doi.org/10.1007/s10916-021-01718-7","title":"Robust Data Integration Method for Classification of Biomedical Data","display_name":"Robust Data Integration Method for Classification of Biomedical Data","publication_year":2021,"publication_date":"2021-02-23","ids":{"openalex":"https://openalex.org/W3129911909","doi":"https://doi.org/10.1007/s10916-021-01718-7","mag":"3129911909","pmid":"https://pubmed.ncbi.nlm.nih.gov/33624190"},"language":"en","primary_location":{"id":"doi:10.1007/s10916-021-01718-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10916-021-01718-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10916-021-01718-7.pdf","source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10916-021-01718-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020286403","display_name":"Aneta Polewko-Klim","orcid":"https://orcid.org/0000-0003-1987-7374"},"institutions":[{"id":"https://openalex.org/I245364917","display_name":"University of Bia\u0142ystok","ror":"https://ror.org/01qaqcf60","country_code":"PL","type":"education","lineage":["https://openalex.org/I245364917"]},{"id":"https://openalex.org/I4210087266","display_name":"Institute of Computer Science","ror":"https://ror.org/003fvp964","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210087266","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Aneta Polewko-Klim","raw_affiliation_strings":["Institute of Computer Science, University of Bialystok, Bialystok, Poland. anetapol@uwb.edu.pl","Institute of Computer Science, University of Bialystok, Bialystok, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, University of Bialystok, Bialystok, Poland. anetapol@uwb.edu.pl","institution_ids":["https://openalex.org/I245364917"]},{"raw_affiliation_string":"Institute of Computer Science, University of Bialystok, Bialystok, Poland","institution_ids":["https://openalex.org/I245364917","https://openalex.org/I4210087266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076071146","display_name":"Krzysztof Mnich","orcid":"https://orcid.org/0000-0002-6226-981X"},"institutions":[{"id":"https://openalex.org/I245364917","display_name":"University of Bia\u0142ystok","ror":"https://ror.org/01qaqcf60","country_code":"PL","type":"education","lineage":["https://openalex.org/I245364917"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Mnich","raw_affiliation_strings":["Computational Center, University of Bialystok, Bialystok, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Center, University of Bialystok, Bialystok, Poland","institution_ids":["https://openalex.org/I245364917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065166985","display_name":"Witold R. Rudnicki","orcid":"https://orcid.org/0000-0002-7928-4944"},"institutions":[{"id":"https://openalex.org/I245364917","display_name":"University of Bia\u0142ystok","ror":"https://ror.org/01qaqcf60","country_code":"PL","type":"education","lineage":["https://openalex.org/I245364917"]},{"id":"https://openalex.org/I4210087266","display_name":"Institute of Computer Science","ror":"https://ror.org/003fvp964","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210087266","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Witold R. Rudnicki","raw_affiliation_strings":["Computational Center, University of Bialystok, Bialystok, Poland","Institute of Computer Science, University of Bialystok, Bialystok, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7928-4944","affiliations":[{"raw_affiliation_string":"Computational Center, University of Bialystok, Bialystok, Poland","institution_ids":["https://openalex.org/I245364917"]},{"raw_affiliation_string":"Institute of Computer Science, University of Bialystok, Bialystok, Poland","institution_ids":["https://openalex.org/I245364917","https://openalex.org/I4210087266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020286403"],"corresponding_institution_ids":["https://openalex.org/I245364917","https://openalex.org/I4210087266"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.5147,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74348611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"45","issue":"4","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9502999782562256,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9502999782562256,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9361000061035156,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.7486815452575684},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6353633999824524},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.48861032724380493},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42295053601264954},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.38748231530189514},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3395099937915802},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1486104130744934},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.10117942094802856}],"concepts":[{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.7486815452575684},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6353633999824524},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.48861032724380493},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42295053601264954},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38748231530189514},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3395099937915802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1486104130744934},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.10117942094802856},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079803","descriptor_name":"Data Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000079803","descriptor_name":"Data Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000079803","descriptor_name":"Data Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10916-021-01718-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10916-021-01718-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10916-021-01718-7.pdf","source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},{"id":"pmid:33624190","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33624190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical systems","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7902598","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7902598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Med Syst","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10916-021-01718-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10916-021-01718-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10916-021-01718-7.pdf","source":{"id":"https://openalex.org/S37151855","display_name":"Journal of Medical Systems","issn_l":"0148-5598","issn":["0148-5598","1573-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3129911909.pdf","grobid_xml":"https://content.openalex.org/works/W3129911909.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W50715096","https://openalex.org/W273955616","https://openalex.org/W1487321909","https://openalex.org/W1700449338","https://openalex.org/W1972978214","https://openalex.org/W1980937575","https://openalex.org/W2015780328","https://openalex.org/W2028403821","https://openalex.org/W2037485911","https://openalex.org/W2064902953","https://openalex.org/W2068523052","https://openalex.org/W2090890710","https://openalex.org/W2091314883","https://openalex.org/W2099951161","https://openalex.org/W2106525823","https://openalex.org/W2109384743","https://openalex.org/W2109553965","https://openalex.org/W2110065044","https://openalex.org/W2110464963","https://openalex.org/W2116802246","https://openalex.org/W2130004766","https://openalex.org/W2140284275","https://openalex.org/W2156665896","https://openalex.org/W2160697532","https://openalex.org/W2189374991","https://openalex.org/W2264481086","https://openalex.org/W2375577403","https://openalex.org/W2405126577","https://openalex.org/W2410143861","https://openalex.org/W2413635030","https://openalex.org/W2567080747","https://openalex.org/W2574721333","https://openalex.org/W2582743722","https://openalex.org/W2768109521","https://openalex.org/W2792874817","https://openalex.org/W2810986024","https://openalex.org/W2911964244","https://openalex.org/W2912411326","https://openalex.org/W2924357470","https://openalex.org/W2924366642","https://openalex.org/W2945103729","https://openalex.org/W2963686598","https://openalex.org/W2971103481","https://openalex.org/W2973418100","https://openalex.org/W2996785909","https://openalex.org/W3003192283","https://openalex.org/W3011398700","https://openalex.org/W3012351867","https://openalex.org/W3037645147","https://openalex.org/W3087903625","https://openalex.org/W3102943483","https://openalex.org/W3119904342","https://openalex.org/W4233056867","https://openalex.org/W6603348255"],"related_works":["https://openalex.org/W2124655189","https://openalex.org/W1993282409","https://openalex.org/W2003798170","https://openalex.org/W4380886672","https://openalex.org/W2808460530","https://openalex.org/W4380684963","https://openalex.org/W2745317272","https://openalex.org/W4280505519","https://openalex.org/W2126703991","https://openalex.org/W2610897791"],"abstract_inverted_index":{"We":[0,221],"present":[1],"a":[2,28,117],"protocol":[3,69],"for":[4,16,88,164,178,254],"integrating":[5],"two":[6,194,206],"types":[7,85],"of":[8,20,43,109,127,150,154,189,227,246],"biological":[9],"data":[10,34,56,84,112,128],"-":[11,15],"clinical":[12,45,89,92,180,191,207],"and":[13,32,77,102,122,132,168,193,209,237],"molecular":[14,55,199],"more":[17],"effective":[18],"classification":[19,51],"patients":[21],"with":[22,116,124],"cancer.":[23],"The":[24,58,67,107,138],"proposed":[25],"approach":[26],"is":[27,47,158],"hybrid":[29,39,68,111,139,161],"between":[30],"early":[31,130],"late":[33,133],"integration":[35,113,131,134],"strategy.":[36],"In":[37],"this":[38],"protocol,":[40],"the":[41,50,110,148,151,160,185,217,225,228,233],"set":[42],"informative":[44],"features":[46,196,208],"extended":[48],"by":[49,147],"results":[52,59,143],"based":[53,231],"on":[54,232],"sets.":[57],"are":[60],"then":[61],"treated":[62],"as":[63],"new":[64],"synthetic":[65,195,211,229],"variables.":[66],"was":[70,114],"applied":[71],"to":[72,144,174,215,243],"METABRIC":[73],"breast":[74,183],"cancer":[75,179],"samples":[76],"TCGA":[78],"urothelial":[79,202],"bladder":[80,203],"carcinoma":[81],"samples.":[82],"Various":[83],"were":[86,213],"used":[87],"endpoint":[90],"prediction:":[91],"data,":[93],"gene":[94],"expression,":[95],"somatic":[96],"copy":[97,238],"number":[98,239],"aberrations,":[99],"RNA-Seq,":[100],"methylation,":[101],"reverse":[103],"phase":[104],"protein":[105],"array.":[106],"performance":[108],"evaluated":[115],"repeated":[118],"cross":[119],"validation":[120],"procedure":[121],"compared":[123],"other":[125],"methods":[126],"integration:":[129],"via":[135],"super":[136,155],"learning.":[137,156],"method":[140,162],"gave":[141],"similar":[142],"those":[145],"obtained":[146,197],"best":[149,218],"tested":[152],"variants":[153],"What":[157],"more,":[159],"allowed":[163],"further":[165],"sensitivity":[166],"analysis":[167],"recursive":[169],"feature":[170],"elimination,":[171],"which":[172],"led":[173],"compact":[175],"predictive":[176,219],"models":[177],"endpoints.":[181],"For":[182,201],"cancer,":[184],"final":[186],"model":[187],"consists":[188],"eight":[190],"variables":[192,230],"from":[198],"data.":[200],"carcinoma,":[204],"only":[205],"one":[210],"variable":[212],"necessary":[214],"build":[216],"model.":[220],"have":[222],"shown":[223],"that":[224],"inclusion":[226,255],"RNA":[234],"expression":[235],"levels":[236],"alterations":[240],"can":[241],"lead":[242],"improved":[244],"quality":[245],"prognostic":[247],"tests.":[248],"Thus,":[249],"it":[250],"should":[251],"be":[252],"considered":[253],"in":[256],"wider":[257],"medical":[258],"practice.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}