{"id":"https://openalex.org/W7131091656","doi":"https://doi.org/10.1007/s10827-026-00925-w","title":"Co-simulation framework combining a microscopically detailed point neuron model of the hippocampal CA1 region with the macroscopic high-resolution virtual brain model","display_name":"Co-simulation framework combining a microscopically detailed point neuron model of the hippocampal CA1 region with the macroscopic high-resolution virtual brain model","publication_year":2026,"publication_date":"2026-02-23","ids":{"openalex":"https://openalex.org/W7131091656","doi":"https://doi.org/10.1007/s10827-026-00925-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41729483"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-026-00925-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-026-00925-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-026-00925-w.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10827-026-00925-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126649446","display_name":"Lorenzo Tartarini","orcid":null},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Tartarini","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858946","display_name":"Paul Triebkorn","orcid":"https://orcid.org/0000-0002-0371-8400"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Triebkorn","raw_affiliation_strings":["Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019907828","display_name":"Lionel Kusch","orcid":"https://orcid.org/0000-0003-3848-914X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Kusch","raw_affiliation_strings":["Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084544794","display_name":"Sergio Solinas","orcid":"https://orcid.org/0000-0002-8605-8515"},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Solinas","raw_affiliation_strings":["Department of Engineering, University of Sassari, Sassari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Sassari, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125696916","display_name":"Huifang Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Huifang Wang","raw_affiliation_strings":["Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052590671","display_name":"Daniela Gandolfi","orcid":"https://orcid.org/0000-0003-2315-2309"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Gandolfi","raw_affiliation_strings":["Artificial Intelligence Research and Innovation Center AIRI, University of Modena and Reggio Emilia, Modena, Italy","Department of Engineering \"Enzo Ferrari\", University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence Research and Innovation Center AIRI, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Engineering \"Enzo Ferrari\", University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124899638","display_name":"Viktor Jirsa","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Viktor Jirsa","raw_affiliation_strings":["Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210110495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004904701","display_name":"Jonathan Mapelli","orcid":"https://orcid.org/0000-0002-0381-1576"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Jonathan Mapelli","raw_affiliation_strings":["Center for Neuroscience and Neurotechnologies, University of Modena and Reggio Emilia, Modena, Italy. jonathan.mapelli@unimore.it","Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. jonathan.mapelli@unimore.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience and Neurotechnologies, University of Modena and Reggio Emilia, Modena, Italy. jonathan.mapelli@unimore.it","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. jonathan.mapelli@unimore.it","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004904701"],"corresponding_institution_ids":["https://openalex.org/I122346577"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":8.8656,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95758197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"54","issue":"2","first_page":"137","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.3801000118255615,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.3801000118255615,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.3628999888896942,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.7444000244140625},{"id":"https://openalex.org/keywords/microscale-chemistry","display_name":"Microscale chemistry","score":0.7005000114440918},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5113000273704529},{"id":"https://openalex.org/keywords/theory-of-computation","display_name":"Theory of computation","score":0.44780001044273376},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.446399986743927},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.3937000036239624},{"id":"https://openalex.org/keywords/biological-neuron-model","display_name":"Biological neuron model","score":0.36800000071525574},{"id":"https://openalex.org/keywords/multiscale-modeling","display_name":"Multiscale modeling","score":0.3598000109195709}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7444000244140625},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7271999716758728},{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.7005000114440918},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5113000273704529},{"id":"https://openalex.org/C24858836","wikidata":"https://www.wikidata.org/wiki/Q844718","display_name":"Theory of computation","level":2,"score":0.44780001044273376},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.446399986743927},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3903000056743622},{"id":"https://openalex.org/C186565885","wikidata":"https://www.wikidata.org/wiki/Q1651163","display_name":"Biological neuron model","level":3,"score":0.36800000071525574},{"id":"https://openalex.org/C141123601","wikidata":"https://www.wikidata.org/wiki/Q6935072","display_name":"Multiscale modeling","level":2,"score":0.3598000109195709},{"id":"https://openalex.org/C15286952","wikidata":"https://www.wikidata.org/wiki/Q8037925","display_name":"Computational neuroscience","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C150303390","wikidata":"https://www.wikidata.org/wiki/Q1983852","display_name":"Virtual actor","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C114725131","wikidata":"https://www.wikidata.org/wiki/Q190837","display_name":"Tipping point (physics)","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C194969405","wikidata":"https://www.wikidata.org/wiki/Q170519","display_name":"Virtual reality","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C2781369091","wikidata":"https://www.wikidata.org/wiki/Q2303730","display_name":"Place cell","level":3,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10827-026-00925-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-026-00925-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-026-00925-w.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:41729483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41729483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":null},{"id":"pmh:oai:iris.unimore.it:11380/1399988","is_oa":true,"landing_page_url":"https://hdl.handle.net/11380/1399988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13233651","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13233651/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10827-026-00925-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-026-00925-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-026-00925-w.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1658616865","display_name":null,"funder_award_id":"1U54MH091657","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G190268827","display_name":null,"funder_award_id":"IR0000011","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3323308467","display_name":null,"funder_award_id":"PE0000006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3551564797","display_name":"EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health","funder_award_id":"101147319","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3899020896","display_name":null,"funder_award_id":"B51E22000150006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5055238918","display_name":null,"funder_award_id":"CUP B51E22000150006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8299918676","display_name":null,"funder_award_id":"1U54MH091657","funder_id":"https://openalex.org/F4320332884","funder_display_name":"McDonnell Center for Systems Neuroscience"},{"id":"https://openalex.org/G8301431789","display_name":null,"funder_award_id":"101147319","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320311022","display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","ror":"https://ror.org/02d4c4y02"},{"id":"https://openalex.org/F4320315820","display_name":"Danish Cancer Society Research Center","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332884","display_name":"McDonnell Center for Systems Neuroscience","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7131091656.pdf"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1983208069","https://openalex.org/W2014059618","https://openalex.org/W2024729467","https://openalex.org/W2031543773","https://openalex.org/W2052394872","https://openalex.org/W2063094367","https://openalex.org/W2074725578","https://openalex.org/W2087861759","https://openalex.org/W2613409207","https://openalex.org/W2728900082","https://openalex.org/W3094495324","https://openalex.org/W4292181496","https://openalex.org/W4311531299","https://openalex.org/W4360612468","https://openalex.org/W4382678900","https://openalex.org/W4391750962","https://openalex.org/W4392351678","https://openalex.org/W4401053309","https://openalex.org/W6929090935","https://openalex.org/W6930851588","https://openalex.org/W6966708768"],"related_works":[],"abstract_inverted_index":{"The":[0],"human":[1,50],"brain":[2,111],"is":[3],"a":[4,35,44,56],"complex":[5],"adaptive":[6],"system":[7],"characterized":[8],"by":[9],"dynamic":[10],"processes":[11],"operating":[12],"across":[13],"multiple":[14],"spatio-temporal":[15],"scales.":[16],"Capturing":[17],"these":[18],"dynamics":[19,103],"requires":[20],"computational":[21],"models":[22],"that":[23,39],"can":[24],"integrate":[25],"different":[26],"levels":[27],"of":[28,48,59,100,121],"resolution.":[29,94],"In":[30],"this":[31,122],"work":[32],"we":[33],"present":[34],"multiscale":[36],"co-simulation":[37],"framework":[38],"couples":[40],"whole-brain":[41],"modeling":[42],"with":[43,73,104],"detailed":[45],"point-neuron":[46],"model":[47,84],"the":[49,60,74,80,82,98,119],"hippocampal":[51],"CA1":[52,83],"region.":[53],"We":[54],"used":[55],"high-resolution":[57],"implementation":[58],"\"The":[61],"Virtual":[62],"Brain\"":[63],"(TVB),":[64],"in":[65,129],"which":[66],"cortical":[67],"surface":[68],"mesh":[69],"vertices":[70],"are":[71],"embedded":[72],"Spatial":[75],"Epileptor":[76],"Model":[77],"(SEM).":[78],"At":[79],"microscale,":[81],"captures":[85],"neuronal":[86,106],"activity":[87],"at":[88],"micrometer":[89],"spatial":[90],"and":[91],"sub-millisecond":[92],"temporal":[93],"This":[95],"integration":[96],"enables":[97],"simulation":[99],"macroscale":[101],"epileptic":[102],"microscale":[105],"precision":[107],"within":[108],"anatomically":[109],"grounded":[110],"regions,":[112],"facilitating":[113],"cross-scale":[114],"communication.":[115],"These":[116],"results":[117],"demonstrate":[118],"potential":[120],"approach":[123],"to":[124],"advance":[125],"mechanism-driven,":[126],"personalized":[127],"medicine":[128],"clinical":[130],"neuroscience.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-02-24T00:00:00"}
