{"id":"https://openalex.org/W4225248014","doi":"https://doi.org/10.1007/s10827-022-00811-1","title":"A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level","display_name":"A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level","publication_year":2022,"publication_date":"2022-01-15","ids":{"openalex":"https://openalex.org/W4225248014","doi":"https://doi.org/10.1007/s10827-022-00811-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35031915"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018882458","display_name":"Damien Depannemaecker","orcid":"https://orcid.org/0000-0003-1936-4560"},"institutions":[{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Damien Depannemaecker","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France. damien.d@cnrs.fr","Department of Integrative and Computational Neuroscience, Institut Neuro-PSI, CNRS, Gif-sur-Yvette, France. damien.d@cnrs.fr","Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade de Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. damien.d@cnrs.fr","Institut de Neurosciences des Syst\u00e8mes","Institut des Neurosciences Paris-Saclay"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France. damien.d@cnrs.fr","institution_ids":[]},{"raw_affiliation_string":"Department of Integrative and Computational Neuroscience, Institut Neuro-PSI, CNRS, Gif-sur-Yvette, France. damien.d@cnrs.fr","institution_ids":[]},{"raw_affiliation_string":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade de Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. damien.d@cnrs.fr","institution_ids":[]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]},{"raw_affiliation_string":"Institut des Neurosciences Paris-Saclay","institution_ids":["https://openalex.org/I4210086740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090259594","display_name":"Anton Ivanov","orcid":"https://orcid.org/0000-0002-8650-6322"},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anton Ivanov","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108351512","display_name":"Davide Lillo","orcid":null},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Davide Lillo","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086387478","display_name":"Len Spek","orcid":"https://orcid.org/0000-0003-4504-8131"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Len Spek","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","Institut de Neurosciences des Syst\u00e8mes"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038141417","display_name":"Christophe Bernard","orcid":"https://orcid.org/0000-0003-3014-1966"},"institutions":[{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Bernard","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047727568","display_name":"Viktor Jirsa","orcid":"https://orcid.org/0000-0002-8251-8860"},"institutions":[{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Viktor Jirsa","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018882458"],"corresponding_institution_ids":["https://openalex.org/I4210086740","https://openalex.org/I4210110495"],"apc_list":{"value":2590,"currency":"EUR","value_usd":3390},"apc_paid":{"value":2590,"currency":"EUR","value_usd":3390},"fwci":4.5451,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.96032699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"50","issue":"1","first_page":"33","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.7668310403823853},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.7048569917678833},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7048313617706299},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6090244650840759},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5878604054450989},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.5324783325195312},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.41268569231033325},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.281532347202301},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19655781984329224},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1339074969291687}],"concepts":[{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.7668310403823853},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7048569917678833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7048313617706299},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6090244650840759},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5878604054450989},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.5324783325195312},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41268569231033325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.281532347202301},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19655781984329224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1339074969291687},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:35031915","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35031915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/df4eeb82-3e6e-46ef-ab89-c48f8d8a69d8","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/df4eeb82-3e6e-46ef-ab89-c48f8d8a69d8","pdf_url":"https://ris.utwente.nl/ws/files/294434896/Depannemaecker2022Unified.pdf","source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Depannemaecker, D, Ivanov, A, Lillo, D, Spek, L, Bernard, C & Jirsa, V 2022, 'A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level', Journal of computational neuroscience, vol. 50, no. 1, pp. 33-49. https://doi.org/10.1007/s10827-022-00811-1","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-02980442v2","is_oa":true,"landing_page_url":"https://hal.science/hal-02980442","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Computational Neuroscience, 2022, &#x27E8;10.1007/s10827-022-00811-1&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:8818009","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8818009","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4225248014.pdf","grobid_xml":"https://content.openalex.org/works/W4225248014.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W120845308","https://openalex.org/W416630258","https://openalex.org/W1576838367","https://openalex.org/W1801705511","https://openalex.org/W1880195515","https://openalex.org/W1938812097","https://openalex.org/W1972482555","https://openalex.org/W1973599366","https://openalex.org/W1975004590","https://openalex.org/W1979787136","https://openalex.org/W1981082198","https://openalex.org/W1985940938","https://openalex.org/W1986729839","https://openalex.org/W1987471043","https://openalex.org/W1987793077","https://openalex.org/W1988054515","https://openalex.org/W1988357583","https://openalex.org/W2000690216","https://openalex.org/W2001849190","https://openalex.org/W2003102260","https://openalex.org/W2007924028","https://openalex.org/W2019203278","https://openalex.org/W2034675173","https://openalex.org/W2043437580","https://openalex.org/W2046686563","https://openalex.org/W2048509758","https://openalex.org/W2052394872","https://openalex.org/W2054009399","https://openalex.org/W2055401067","https://openalex.org/W2061417745","https://openalex.org/W2078156409","https://openalex.org/W2080132103","https://openalex.org/W2081895884","https://openalex.org/W2081940193","https://openalex.org/W2082471900","https://openalex.org/W2095796165","https://openalex.org/W2116394679","https://openalex.org/W2117632966","https://openalex.org/W2117918745","https://openalex.org/W2132047598","https://openalex.org/W2133100820","https://openalex.org/W2144759791","https://openalex.org/W2145698896","https://openalex.org/W2150497419","https://openalex.org/W2152472106","https://openalex.org/W2154731415","https://openalex.org/W2155965080","https://openalex.org/W2163334026","https://openalex.org/W2167970717","https://openalex.org/W2181596189","https://openalex.org/W2219448291","https://openalex.org/W2227238226","https://openalex.org/W2256900457","https://openalex.org/W2301435056","https://openalex.org/W2324026601","https://openalex.org/W2343448033","https://openalex.org/W2399765058","https://openalex.org/W2408778745","https://openalex.org/W2411037073","https://openalex.org/W2413349844","https://openalex.org/W2417093385","https://openalex.org/W2417863416","https://openalex.org/W2498750458","https://openalex.org/W2610960352","https://openalex.org/W2767534068","https://openalex.org/W2797211648","https://openalex.org/W2807174788","https://openalex.org/W2888815451","https://openalex.org/W2955721310","https://openalex.org/W2963587342","https://openalex.org/W3005543067","https://openalex.org/W3044586123","https://openalex.org/W3099188581","https://openalex.org/W3120170245","https://openalex.org/W3132853301","https://openalex.org/W4246553649","https://openalex.org/W6995974915","https://openalex.org/W7018176246","https://openalex.org/W7020123318","https://openalex.org/W7027010299"],"related_works":["https://openalex.org/W2130055373","https://openalex.org/W2046007129","https://openalex.org/W2075017247","https://openalex.org/W1988222024","https://openalex.org/W2089619207","https://openalex.org/W2078261043","https://openalex.org/W4318917056","https://openalex.org/W2129833097","https://openalex.org/W2098236325","https://openalex.org/W2103977515"],"abstract_inverted_index":{"The":[0,71],"majority":[1,296],"of":[2,68,86,94,149,153,159,206,234,259,263,278,297,323,331,338,341,374,388],"seizures":[3,131],"recorded":[4],"in":[5,161,202,221,240,242,300],"humans":[6],"and":[7,34,40,46,82,128,140,171,177,190,215,248,286,288,325,359,369,397],"experimental":[8,129,168,243,301],"animal":[9],"models":[10,244,282],"can":[11,111,132,179,200,266,273],"be":[12,267],"described":[13,268],"by":[14,30,231,269],"a":[15,31,59,65,101,123,203,207,227,260,295,320,361,375,385],"generic":[16,376],"phenomenological":[17],"mathematical":[18,270],"model,":[19,24],"the":[20,54,75,83,87,91,95,115,150,154,162,183,211,222,232,257,316,329,332,339,352,372,381],"Epileptor.":[21,155],"In":[22,126,351],"this":[23],"seizure-like":[25],"events":[26],"(SLEs)":[27],"are":[28,146,393],"driven":[29],"slow":[32,76,102],"variable":[33],"occur":[35,113,181],"via":[36],"saddle":[37],"node":[38],"(SN)":[39],"homoclinic":[41],"bifurcations":[42,110],"at":[43,53,114,182,210,245,380],"seizure":[44],"onset":[45],"offset,":[47],"respectively.":[48],"Here":[49],"we":[50,104,173,355],"investigated":[51],"SLEs":[52,107],"single":[55,116,184,212,382],"cell":[56,117,185,383],"level":[57,118,214],"using":[58,251],"biophysically":[60],"relevant":[61],"neuron":[62,213],"model":[63,163,209,364],"including":[64],"slow/fast":[66],"system":[67],"four":[69],"equations.":[70],"two":[72,84,275],"equations":[73,85],"for":[74],"subsystem":[77,89],"describe":[78],"ion":[79],"concentration":[80,158],"variations":[81],"fast":[88],"delineate":[90],"electrophysiological":[92,252],"activities":[93,144,298,391],"neuron.":[96],"Using":[97],"extracellular":[98,120,157],"K<sup>+</sup>":[99,121,160],"as":[100,197,219],"variable,":[103],"report":[105],"that":[106,175,392],"with":[108],"SN/homoclinic":[109],"readily":[112],"when":[119],"reaches":[122],"critical":[124],"value.":[125],"patients":[127,241],"models,":[130,314],"also":[133,147,180,305],"evolve":[134],"into":[135],"sustained":[136,398],"ictal":[137,399],"activity":[138],"(SIA)":[139],"depolarization":[141,395],"block":[142],"(DB),":[143],"which":[145,192,265],"parts":[148],"dynamic":[151],"repertoire":[152],"Increasing":[156],"to":[164,328,346,365],"values":[165],"found":[166],"during":[167],"status":[169],"epilepticus":[170],"DB,":[172,191],"show":[174],"SIA":[176],"DB":[178],"level.":[186],"Thus,":[187],"seizures,":[188,264,394],"SIA,":[189],"have":[193,237,283,306],"been":[194,238],"first":[195],"identified":[196],"network":[198],"events,":[199],"exist":[201],"unified":[204,386],"framework":[205,387],"biophysical":[208,363],"exhibit":[216],"similar":[217],"dynamics":[218],"observed":[220,299],"Epileptor.Author":[223],"Summary:":[224],"Epilepsy":[225],"is":[226,344],"neurological":[228],"disorder":[229],"characterized":[230,239],"occurrence":[233],"seizures.":[235],"Seizures":[236],"both":[246,357],"macroscopic":[247],"microscopic":[249],"scales":[250],"recordings.":[253],"Experimental":[254],"works":[255],"allowed":[256],"establishment":[258],"detailed":[261,290,362],"taxonomy":[262],"models.":[271,279],"We":[272,378],"distinguish":[274],"main":[276],"types":[277],"Phenomenological":[280],"(generic)":[281],"few":[284],"parameters":[285,326],"variables":[287,324],"permit":[289],"dynamical":[291,349],"studies":[292],"often":[293],"capturing":[294],"conditions.":[302],"But":[303],"they":[304,335],"abstract":[307],"parameters,":[308],"making":[309],"biological":[310,333],"interpretation":[311],"difficult.":[312],"Biophysical":[313],"on":[315],"other":[317],"hand,":[318],"use":[319],"large":[321],"number":[322],"due":[327],"complexity":[330],"systems":[334],"represent.":[336],"Because":[337],"multiplicity":[340],"solutions,":[342],"it":[343],"difficult":[345],"extract":[347],"general":[348],"rules.":[350],"present":[353],"work,":[354],"integrate":[356],"approaches":[358],"reduce":[360],"sufficiently":[366],"low-dimensional":[367],"equations,":[368],"thus":[370],"maintaining":[371],"advantages":[373],"model.":[377],"propose,":[379],"level,":[384],"different":[389],"pathological":[390],"block,":[396],"activity.":[400]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
