{"id":"https://openalex.org/W4225248014","doi":"https://doi.org/10.1007/s10827-022-00811-1","title":"A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level","display_name":"A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level","publication_year":2022,"publication_date":"2022-01-15","ids":{"openalex":"https://openalex.org/W4225248014","doi":"https://doi.org/10.1007/s10827-022-00811-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35031915"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018882458","display_name":"Damien Depannemaecker","orcid":"https://orcid.org/0000-0003-1936-4560"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086635","display_name":"Sociedade Brasileira de Neuroci\u00eancias e Comportamento","ror":"https://ror.org/003e2jn43","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210086635"]},{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["BR","FR"],"is_corresponding":true,"raw_author_name":"Damien Depannemaecker","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France. damien.d@cnrs.fr","Department of Integrative and Computational Neuroscience, Institut Neuro-PSI, CNRS, Gif-sur-Yvette, France. damien.d@cnrs.fr","Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade de Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. damien.d@cnrs.fr","Institut de Neurosciences des Syst\u00e8mes","Institut des Neurosciences Paris-Saclay"],"raw_orcid":"https://orcid.org/0000-0003-1936-4560","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France. damien.d@cnrs.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210110495"]},{"raw_affiliation_string":"Department of Integrative and Computational Neuroscience, Institut Neuro-PSI, CNRS, Gif-sur-Yvette, France. damien.d@cnrs.fr","institution_ids":["https://openalex.org/I4210086740","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade de Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. damien.d@cnrs.fr","institution_ids":["https://openalex.org/I4210086635"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]},{"raw_affiliation_string":"Institut des Neurosciences Paris-Saclay","institution_ids":["https://openalex.org/I4210086740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090259594","display_name":"Anton Ivanov","orcid":"https://orcid.org/0000-0002-8650-6322"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anton Ivanov","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108351512","display_name":"Davide Lillo","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Davide Lillo","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086387478","display_name":"Len Spek","orcid":"https://orcid.org/0000-0003-4504-8131"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]},{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Len Spek","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","Institut de Neurosciences des Syst\u00e8mes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038141417","display_name":"Christophe Bernard","orcid":"https://orcid.org/0000-0003-3014-1966"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Bernard","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047727568","display_name":"Viktor Jirsa","orcid":"https://orcid.org/0000-0002-8251-8860"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Viktor Jirsa","raw_affiliation_strings":["Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","Institut de Neurosciences des Syst\u00e8mes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Syst\u00e8mes, Aix Marseille University, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I21491767","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut de Neurosciences des Syst\u00e8mes","institution_ids":["https://openalex.org/I4210110495"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018882458"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086635","https://openalex.org/I4210086740","https://openalex.org/I4210110495"],"apc_list":{"value":2590,"currency":"EUR","value_usd":3390},"apc_paid":{"value":2590,"currency":"EUR","value_usd":3390},"fwci":4.332,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.9569756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"50","issue":"1","first_page":"33","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.7668310403823853},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.7048569917678833},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7048313617706299},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6090244650840759},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5878604054450989},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.5324783325195312},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.41268569231033325},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.281532347202301},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19655781984329224},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1339074969291687}],"concepts":[{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.7668310403823853},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7048569917678833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7048313617706299},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6090244650840759},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5878604054450989},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.5324783325195312},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41268569231033325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.281532347202301},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19655781984329224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1339074969291687},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:35031915","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35031915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/df4eeb82-3e6e-46ef-ab89-c48f8d8a69d8","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/df4eeb82-3e6e-46ef-ab89-c48f8d8a69d8","pdf_url":"https://ris.utwente.nl/ws/files/294434896/Depannemaecker2022Unified.pdf","source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Depannemaecker, D, Ivanov, A, Lillo, D, Spek, L, Bernard, C & Jirsa, V 2022, 'A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level', Journal of computational neuroscience, vol. 50, no. 1, pp. 33-49. https://doi.org/10.1007/s10827-022-00811-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02980442v2","is_oa":true,"landing_page_url":"https://hal.science/hal-02980442","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Computational Neuroscience, 2022, &#x27E8;10.1007/s10827-022-00811-1&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8818009","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8818009","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10827-022-00811-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10827-022-00811-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10827-022-00811-1.pdf","source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5299999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4225248014.pdf","grobid_xml":"https://content.openalex.org/works/W4225248014.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W120845308","https://openalex.org/W416630258","https://openalex.org/W1576838367","https://openalex.org/W1801705511","https://openalex.org/W1880195515","https://openalex.org/W1938812097","https://openalex.org/W1972482555","https://openalex.org/W1973599366","https://openalex.org/W1975004590","https://openalex.org/W1979787136","https://openalex.org/W1981082198","https://openalex.org/W1985940938","https://openalex.org/W1986729839","https://openalex.org/W1987471043","https://openalex.org/W1987793077","https://openalex.org/W1988054515","https://openalex.org/W1988357583","https://openalex.org/W2000690216","https://openalex.org/W2001849190","https://openalex.org/W2003102260","https://openalex.org/W2007924028","https://openalex.org/W2019203278","https://openalex.org/W2034675173","https://openalex.org/W2043437580","https://openalex.org/W2046686563","https://openalex.org/W2048509758","https://openalex.org/W2052394872","https://openalex.org/W2054009399","https://openalex.org/W2055401067","https://openalex.org/W2061417745","https://openalex.org/W2078156409","https://openalex.org/W2080132103","https://openalex.org/W2081895884","https://openalex.org/W2081940193","https://openalex.org/W2082471900","https://openalex.org/W2095796165","https://openalex.org/W2116394679","https://openalex.org/W2117632966","https://openalex.org/W2117918745","https://openalex.org/W2132047598","https://openalex.org/W2133100820","https://openalex.org/W2144759791","https://openalex.org/W2145698896","https://openalex.org/W2150497419","https://openalex.org/W2152472106","https://openalex.org/W2154731415","https://openalex.org/W2155965080","https://openalex.org/W2163334026","https://openalex.org/W2167970717","https://openalex.org/W2181596189","https://openalex.org/W2219448291","https://openalex.org/W2227238226","https://openalex.org/W2256900457","https://openalex.org/W2301435056","https://openalex.org/W2324026601","https://openalex.org/W2343448033","https://openalex.org/W2399765058","https://openalex.org/W2408778745","https://openalex.org/W2411037073","https://openalex.org/W2413349844","https://openalex.org/W2417093385","https://openalex.org/W2417863416","https://openalex.org/W2498750458","https://openalex.org/W2610960352","https://openalex.org/W2767534068","https://openalex.org/W2797211648","https://openalex.org/W2807174788","https://openalex.org/W2888815451","https://openalex.org/W2955721310","https://openalex.org/W2963587342","https://openalex.org/W3005543067","https://openalex.org/W3044586123","https://openalex.org/W3099188581","https://openalex.org/W3120170245","https://openalex.org/W3132853301","https://openalex.org/W4246553649","https://openalex.org/W6995974915","https://openalex.org/W7018176246","https://openalex.org/W7020123318","https://openalex.org/W7027010299"],"related_works":["https://openalex.org/W2130055373","https://openalex.org/W2046007129","https://openalex.org/W2075017247","https://openalex.org/W1988222024","https://openalex.org/W2089619207","https://openalex.org/W2078261043","https://openalex.org/W4318917056","https://openalex.org/W2129833097","https://openalex.org/W2098236325","https://openalex.org/W2103977515"],"abstract_inverted_index":{"Abstract":[0],"The":[1,72],"majority":[2,301],"of":[3,69,87,95,152,156,162,210,239,264,268,283,302,328,336,343,346,379,393],"seizures":[4,134],"recorded":[5],"in":[6,165,206,225,245,247,305],"humans":[7],"and":[8,35,41,47,83,131,143,175,181,194,219,253,291,293,330,364,374,402],"experimental":[9,132,172,248,306],"animal":[10],"models":[11,249,287],"can":[12,113,135,183,204,271,278],"be":[13,272],"described":[14,273],"by":[15,31,236,274],"a":[16,32,60,66,103,126,207,211,232,265,300,325,366,380,390],"generic":[17,381],"phenomenological":[18],"mathematical":[19,275],"model,":[20,25],"the":[21,55,76,84,88,92,96,117,153,157,166,187,215,226,237,262,321,334,337,344,357,377,386],"Epileptor.":[22,158,227],"In":[23,129,356],"this":[24],"seizure-like":[26],"events":[27],"(SLEs)":[28],"are":[29,149,398],"driven":[30],"slow":[33,77,104],"variable":[34],"occur":[36,115,185],"via":[37],"saddle":[38],"node":[39],"(SN)":[40],"homoclinic":[42],"bifurcations":[43,112],"at":[44,54,116,186,214,250,385],"seizure":[45],"onset":[46],"offset,":[48],"respectively.":[49],"Here":[50],"we":[51,106,177,360],"investigated":[52],"SLEs":[53,109],"single":[56,118,188,216,387],"cell":[57,119,189,388],"level":[58,120,218],"using":[59,256],"biophysically":[61],"relevant":[62],"neuron":[63,217],"model":[64,167,213,369],"including":[65],"slow/fast":[67],"system":[68],"four":[70],"equations.":[71],"two":[73,85,280],"equations":[74,86],"for":[75],"subsystem":[78,90],"describe":[79],"ion":[80],"concentration":[81,161],"variations":[82],"fast":[89],"delineate":[91],"electrophysiological":[93,257],"activities":[94,147,303,396],"neuron.":[97],"Using":[98],"extracellular":[99,122,160],"K":[100,123,163],"+":[101,124,164],"as":[102,201,223],"variable,":[105],"report":[107],"that":[108,179,397],"with":[110],"SN/homoclinic":[111],"readily":[114],"when":[121],"reaches":[125],"critical":[127],"value.":[128],"patients":[130,246],"models,":[133,319],"also":[136,150,184,310],"evolve":[137],"into":[138],"sustained":[139,403],"ictal":[140,404],"activity":[141],"(SIA)":[142],"depolarization":[144,400],"block":[145],"(DB),":[146],"which":[148,196,270],"parts":[151],"dynamic":[154],"repertoire":[155],"Increasing":[159],"to":[168,333,351,370],"values":[169],"found":[170],"during":[171],"status":[173],"epilepticus":[174],"DB,":[176,195],"show":[178],"SIA":[180],"DB":[182],"level.":[190],"Thus,":[191],"seizures,":[192,269,399],"SIA,":[193],"have":[197,242,288,311],"been":[198,243],"first":[199],"identified":[200],"network":[202],"events,":[203],"exist":[205],"unified":[208,391],"framework":[209,392],"biophysical":[212,368],"exhibit":[220],"similar":[221],"dynamics":[222],"observed":[224,304],"Author":[228],"Summary:":[229],"Epilepsy":[230],"is":[231,349],"neurological":[233],"disorder":[234],"characterized":[235,244],"occurrence":[238],"seizures.":[240],"Seizures":[241],"both":[251,362],"macroscopic":[252],"microscopic":[254],"scales":[255],"recordings.":[258],"Experimental":[259],"works":[260],"allowed":[261],"establishment":[263],"detailed":[266,295,367],"taxonomy":[267],"models.":[276,284],"We":[277,383],"distinguish":[279],"main":[281],"types":[282],"Phenomenological":[285],"(generic)":[286],"few":[289],"parameters":[290,331],"variables":[292,329],"permit":[294],"dynamical":[296,354],"studies":[297],"often":[298],"capturing":[299],"conditions.":[307],"But":[308],"they":[309,340],"abstract":[312],"parameters,":[313],"making":[314],"biological":[315,338],"interpretation":[316],"difficult.":[317],"Biophysical":[318],"on":[320],"other":[322],"hand,":[323],"use":[324],"large":[326],"number":[327],"due":[332],"complexity":[335],"systems":[339],"represent.":[341],"Because":[342],"multiplicity":[345],"solutions,":[347],"it":[348],"difficult":[350],"extract":[352],"general":[353],"rules.":[355],"present":[358],"work,":[359],"integrate":[361],"approaches":[363],"reduce":[365],"sufficiently":[371],"low-dimensional":[372],"equations,":[373],"thus":[375],"maintaining":[376],"advantages":[378],"model.":[382],"propose,":[384],"level,":[389],"different":[394],"pathological":[395],"block,":[401],"activity.":[405]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
