{"id":"https://openalex.org/W3093197233","doi":"https://doi.org/10.1007/s10827-020-00766-1","title":"Altered neuronal excitability in a Hodgkin-Huxley model incorporating channelopathies of the delayed rectifier potassium channel","display_name":"Altered neuronal excitability in a Hodgkin-Huxley model incorporating channelopathies of the delayed rectifier potassium channel","publication_year":2020,"publication_date":"2020-10-15","ids":{"openalex":"https://openalex.org/W3093197233","doi":"https://doi.org/10.1007/s10827-020-00766-1","mag":"3093197233","pmid":"https://pubmed.ncbi.nlm.nih.gov/33063225"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-020-00766-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-020-00766-1","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012650192","display_name":"Omar A. Hafez","orcid":"https://orcid.org/0000-0002-7846-9226"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar A. Hafez","raw_affiliation_strings":["Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-7846-9226","affiliations":[{"raw_affiliation_string":"Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026083168","display_name":"Allan Gottschalk","orcid":"https://orcid.org/0000-0003-0471-728X"},"institutions":[{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan Gottschalk","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA. agottschalk@jhmi.edu","Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA. agottschalk@jhmi.edu","Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0003-0471-728X","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA. agottschalk@jhmi.edu","institution_ids":["https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA. agottschalk@jhmi.edu","institution_ids":["https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026083168"],"corresponding_institution_ids":["https://openalex.org/I4210150714"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":0.4658,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60087195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"48","issue":"4","first_page":"377","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hodgkin\u2013huxley-model","display_name":"Hodgkin\u2013Huxley model","score":0.6592414975166321},{"id":"https://openalex.org/keywords/inward-rectifier-potassium-ion-channel","display_name":"Inward-rectifier potassium ion channel","score":0.649664580821991},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6250805854797363},{"id":"https://openalex.org/keywords/channelopathy","display_name":"Channelopathy","score":0.6215242743492126},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.6088709235191345},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.43799886107444763},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3587963879108429},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31090933084487915},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21828818321228027}],"concepts":[{"id":"https://openalex.org/C101877181","wikidata":"https://www.wikidata.org/wiki/Q995215","display_name":"Hodgkin\u2013Huxley model","level":2,"score":0.6592414975166321},{"id":"https://openalex.org/C94924445","wikidata":"https://www.wikidata.org/wiki/Q841456","display_name":"Inward-rectifier potassium ion channel","level":4,"score":0.649664580821991},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6250805854797363},{"id":"https://openalex.org/C2777989426","wikidata":"https://www.wikidata.org/wiki/Q2936142","display_name":"Channelopathy","level":2,"score":0.6215242743492126},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.6088709235191345},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.43799886107444763},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3587963879108429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31090933084487915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21828818321228027},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051668","descriptor_name":"Delayed Rectifier Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051668","descriptor_name":"Delayed Rectifier Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051668","descriptor_name":"Delayed Rectifier Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10827-020-00766-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-020-00766-1","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:33063225","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33063225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1017363228","https://openalex.org/W1501360999","https://openalex.org/W1532842753","https://openalex.org/W1542177822","https://openalex.org/W1545694313","https://openalex.org/W1576838367","https://openalex.org/W1596321532","https://openalex.org/W1951749181","https://openalex.org/W1966422754","https://openalex.org/W1980618916","https://openalex.org/W1985940938","https://openalex.org/W1986296955","https://openalex.org/W2003743055","https://openalex.org/W2010078877","https://openalex.org/W2015540983","https://openalex.org/W2016832913","https://openalex.org/W2026810894","https://openalex.org/W2033066780","https://openalex.org/W2035651162","https://openalex.org/W2048584424","https://openalex.org/W2079371292","https://openalex.org/W2083689979","https://openalex.org/W2088254080","https://openalex.org/W2089876099","https://openalex.org/W2090631087","https://openalex.org/W2094086293","https://openalex.org/W2119443761","https://openalex.org/W2128988164","https://openalex.org/W2140202014","https://openalex.org/W2153110368","https://openalex.org/W2275157848","https://openalex.org/W4234546939","https://openalex.org/W4244646296","https://openalex.org/W6626659282","https://openalex.org/W6632565693","https://openalex.org/W6635699308","https://openalex.org/W6659477952","https://openalex.org/W6672571714","https://openalex.org/W6677819394","https://openalex.org/W7058337856"],"related_works":["https://openalex.org/W2284598862","https://openalex.org/W3116719222","https://openalex.org/W4234899225","https://openalex.org/W4386967120","https://openalex.org/W2002475483","https://openalex.org/W2027913161","https://openalex.org/W2103698701","https://openalex.org/W2028247996","https://openalex.org/W2487783762","https://openalex.org/W2352426073"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}