{"id":"https://openalex.org/W2052942976","doi":"https://doi.org/10.1007/s10827-009-0187-x","title":"Exocytotic dynamics and calcium cooperativity effects in the calyx of Held synapse: a modelling study","display_name":"Exocytotic dynamics and calcium cooperativity effects in the calyx of Held synapse: a modelling study","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2052942976","doi":"https://doi.org/10.1007/s10827-009-0187-x","mag":"2052942976","pmid":"https://pubmed.ncbi.nlm.nih.gov/19798561"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-009-0187-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-009-0187-x","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023121014","display_name":"Amparo Gil","orcid":"https://orcid.org/0000-0002-7449-4205"},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Amparo Gil","raw_affiliation_strings":["Depto. de Matem\u00e1tica Aplicada y Ciencias de la Computaci\u00f3n, Universidad de Cantabria, 39005 Santander, Spain. amparo.gil@unican.es","Universidad de Cantabria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depto. de Matem\u00e1tica Aplicada y Ciencias de la Computaci\u00f3n, Universidad de Cantabria, 39005 Santander, Spain. amparo.gil@unican.es","institution_ids":["https://openalex.org/I13134134"]},{"raw_affiliation_string":"Universidad de Cantabria","institution_ids":["https://openalex.org/I13134134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049173707","display_name":"Virginia Gonz\u00e1lez\u2010V\u00e9lez","orcid":"https://orcid.org/0000-0003-4817-8492"},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Virginia Gonz\u00e1lez-V\u00e9lez","raw_affiliation_strings":["Area de Qu\u00edmica Aplicada, Universidad Aut\u00f3noma Metropolitana Azcapotzalco, 02200, M\u00e9xico D.F., Mexico","Universidad Aut\u00f3noma Metropolitana\u2010Azcapotzalco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Area de Qu\u00edmica Aplicada, Universidad Aut\u00f3noma Metropolitana Azcapotzalco, 02200, M\u00e9xico D.F., Mexico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Universidad Aut\u00f3noma Metropolitana\u2010Azcapotzalco","institution_ids":["https://openalex.org/I200362191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023121014"],"corresponding_institution_ids":["https://openalex.org/I13134134"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.6942,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63197913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"28","issue":"1","first_page":"65","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calyx","display_name":"Calyx","score":0.699141263961792},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.592353880405426},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.58543860912323},{"id":"https://openalex.org/keywords/ribbon-synapse","display_name":"Ribbon synapse","score":0.5544530153274536},{"id":"https://openalex.org/keywords/vesicle","display_name":"Vesicle","score":0.5427080392837524},{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.5273657441139221},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.504004180431366},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.48759523034095764},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.4419128894805908},{"id":"https://openalex.org/keywords/active-zone","display_name":"Active zone","score":0.43358397483825684},{"id":"https://openalex.org/keywords/synaptic-vesicle","display_name":"Synaptic vesicle","score":0.3964081108570099},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3456013798713684},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18751001358032227},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14257094264030457},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1421610713005066}],"concepts":[{"id":"https://openalex.org/C2776390344","wikidata":"https://www.wikidata.org/wiki/Q5024772","display_name":"Calyx","level":2,"score":0.699141263961792},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.592353880405426},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.58543860912323},{"id":"https://openalex.org/C38120836","wikidata":"https://www.wikidata.org/wiki/Q7322268","display_name":"Ribbon synapse","level":5,"score":0.5544530153274536},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5427080392837524},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.5273657441139221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.504004180431366},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.48759523034095764},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4419128894805908},{"id":"https://openalex.org/C187102610","wikidata":"https://www.wikidata.org/wiki/Q4677599","display_name":"Active zone","level":5,"score":0.43358397483825684},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.3964081108570099},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3456013798713684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18751001358032227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14257094264030457},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1421610713005066},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10827-009-0187-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-009-0187-x","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:19798561","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19798561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1490183365","https://openalex.org/W1520756199","https://openalex.org/W1532025839","https://openalex.org/W1588802060","https://openalex.org/W1642181682","https://openalex.org/W1664184517","https://openalex.org/W1955716838","https://openalex.org/W1963580947","https://openalex.org/W1964596341","https://openalex.org/W1970288828","https://openalex.org/W1979841513","https://openalex.org/W1989577442","https://openalex.org/W1990740805","https://openalex.org/W1998261042","https://openalex.org/W1998596214","https://openalex.org/W2006585019","https://openalex.org/W2017847991","https://openalex.org/W2019766891","https://openalex.org/W2024048296","https://openalex.org/W2028789389","https://openalex.org/W2039048867","https://openalex.org/W2040618621","https://openalex.org/W2057759105","https://openalex.org/W2078068750","https://openalex.org/W2085537082","https://openalex.org/W2087176067","https://openalex.org/W2087758815","https://openalex.org/W2090662268","https://openalex.org/W2092593123","https://openalex.org/W2094930349","https://openalex.org/W2101691189","https://openalex.org/W2108832750","https://openalex.org/W2121391640","https://openalex.org/W2122383890","https://openalex.org/W2123091486","https://openalex.org/W2128967907","https://openalex.org/W2139939841","https://openalex.org/W2141260882","https://openalex.org/W2154606229","https://openalex.org/W2158561409","https://openalex.org/W2169344023","https://openalex.org/W2268962851","https://openalex.org/W2495550846","https://openalex.org/W2508561383"],"related_works":["https://openalex.org/W2911830206","https://openalex.org/W2064882391","https://openalex.org/W1980345625","https://openalex.org/W2172073217","https://openalex.org/W2022792040","https://openalex.org/W2030877422","https://openalex.org/W2091869150","https://openalex.org/W2750633128","https://openalex.org/W2147111725","https://openalex.org/W2006902206"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}