{"id":"https://openalex.org/W2123085982","doi":"https://doi.org/10.1007/s10827-005-5474-6","title":"A Cellular Mechanism for Graded Persistent Activity in a Model Neuron and Its Implications in Working Memory","display_name":"A Cellular Mechanism for Graded Persistent Activity in a Model Neuron and Its Implications in Working Memory","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2123085982","doi":"https://doi.org/10.1007/s10827-005-5474-6","mag":"2123085982","pmid":"https://pubmed.ncbi.nlm.nih.gov/15789172"},"language":"en","primary_location":{"id":"doi:10.1007/s10827-005-5474-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-005-5474-6","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030187397","display_name":"Jun-nosuke Teramae","orcid":"https://orcid.org/0000-0003-3255-0253"},"institutions":[{"id":"https://openalex.org/I149481174","display_name":"Tamagawa University","ror":"https://ror.org/05f8a4p63","country_code":"JP","type":"education","lineage":["https://openalex.org/I149481174"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-Nosuke Teramae","raw_affiliation_strings":["Brain Science Research Center, Tamagawa University, machida, Tokyo, 194 8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Science Research Center, Tamagawa University, machida, Tokyo, 194 8610, Japan","institution_ids":["https://openalex.org/I149481174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073758227","display_name":"Tomoki Fukai","orcid":"https://orcid.org/0000-0001-6977-5638"},"institutions":[{"id":"https://openalex.org/I149481174","display_name":"Tamagawa University","ror":"https://ror.org/05f8a4p63","country_code":"JP","type":"education","lineage":["https://openalex.org/I149481174"]},{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoki Fukai","raw_affiliation_strings":["Brain Science Research Center and Department of Information-Communication Engineering, Tamagawa University, Machida, Tokyo, 194 8610, Japan","Laboratory for Neural Circuit Theory, Brain Science Institute, RIKEN, Wako, Saitama, 351 0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Science Research Center and Department of Information-Communication Engineering, Tamagawa University, Machida, Tokyo, 194 8610, Japan","institution_ids":["https://openalex.org/I149481174"]},{"raw_affiliation_string":"Laboratory for Neural Circuit Theory, Brain Science Institute, RIKEN, Wako, Saitama, 351 0198, Japan","institution_ids":["https://openalex.org/I2800939219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.0205,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.71360382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"105","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.7756364941596985},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.773527979850769},{"id":"https://openalex.org/keywords/neuronal-firing","display_name":"Neuronal firing","score":0.6725326776504517},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6308363676071167},{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.6024088263511658},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5766329765319824},{"id":"https://openalex.org/keywords/working-memory","display_name":"Working memory","score":0.5137232542037964},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"Entorhinal cortex","score":0.42174649238586426},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4018709659576416},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2975887656211853},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2778364419937134},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.2536821961402893},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.21731597185134888},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15545696020126343},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.1506972312927246}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7756364941596985},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.773527979850769},{"id":"https://openalex.org/C3019868978","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Neuronal firing","level":3,"score":0.6725326776504517},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6308363676071167},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6024088263511658},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5766329765319824},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.5137232542037964},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.42174649238586426},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4018709659576416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2975887656211853},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2778364419937134},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2536821961402893},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.21731597185134888},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15545696020126343},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1506972312927246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10827-005-5474-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10827-005-5474-6","pdf_url":null,"source":{"id":"https://openalex.org/S27455496","display_name":"Journal of Computational Neuroscience","issn_l":"0929-5313","issn":["0929-5313","1573-6873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:15789172","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15789172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.654.4692","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.654.4692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nct.brain.riken.jp/publications/200502_TeramaeFukai_JCN2005.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.46000000834465027}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W121154583","https://openalex.org/W1532842753","https://openalex.org/W1589692855","https://openalex.org/W1594175255","https://openalex.org/W1604195904","https://openalex.org/W1608745771","https://openalex.org/W1650401181","https://openalex.org/W1666469474","https://openalex.org/W1815077724","https://openalex.org/W1818623226","https://openalex.org/W1820758986","https://openalex.org/W1906735024","https://openalex.org/W1930917734","https://openalex.org/W1974948986","https://openalex.org/W1980166477","https://openalex.org/W1982785144","https://openalex.org/W1982815320","https://openalex.org/W1997093700","https://openalex.org/W1997778815","https://openalex.org/W2007263885","https://openalex.org/W2008801811","https://openalex.org/W2018696172","https://openalex.org/W2023699349","https://openalex.org/W2025586244","https://openalex.org/W2025891204","https://openalex.org/W2033957635","https://openalex.org/W2040353213","https://openalex.org/W2041244640","https://openalex.org/W2041690080","https://openalex.org/W2042334236","https://openalex.org/W2046299405","https://openalex.org/W2047807449","https://openalex.org/W2052296894","https://openalex.org/W2052332089","https://openalex.org/W2055568369","https://openalex.org/W2062312213","https://openalex.org/W2071885606","https://openalex.org/W2072459093","https://openalex.org/W2073263421","https://openalex.org/W2073437393","https://openalex.org/W2080027694","https://openalex.org/W2088093088","https://openalex.org/W2095984446","https://openalex.org/W2100688704","https://openalex.org/W2101620490","https://openalex.org/W2113095823","https://openalex.org/W2114542353","https://openalex.org/W2117880956","https://openalex.org/W2122066429","https://openalex.org/W2123383560","https://openalex.org/W2124893433","https://openalex.org/W2125619691","https://openalex.org/W2135011583","https://openalex.org/W2138337623","https://openalex.org/W2147491758","https://openalex.org/W2161983882","https://openalex.org/W2164192685","https://openalex.org/W2166507263","https://openalex.org/W2168096237","https://openalex.org/W2171437709","https://openalex.org/W2311137878"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W2042003698","https://openalex.org/W1964519618","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W4224982892","https://openalex.org/W2074634604","https://openalex.org/W2018319915"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
