{"id":"https://openalex.org/W4415522385","doi":"https://doi.org/10.1007/s10822-025-00675-4","title":"Interconversion of the (+)-O-desmethyltramadol to the lowest-energy conformer when coupled to \u00b5-opioid receptor: comprehensive analysis using in silico molecular modeling","display_name":"Interconversion of the (+)-O-desmethyltramadol to the lowest-energy conformer when coupled to \u00b5-opioid receptor: comprehensive analysis using in silico molecular modeling","publication_year":2025,"publication_date":"2025-10-24","ids":{"openalex":"https://openalex.org/W4415522385","doi":"https://doi.org/10.1007/s10822-025-00675-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41136641"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-025-00675-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00675-4","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062659798","display_name":"Manuel Vel\u00e1zquez","orcid":"https://orcid.org/0000-0001-7191-5855"},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Manuel Vel\u00e1zquez-Ponce","raw_affiliation_strings":["Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico"],"affiliations":[{"raw_affiliation_string":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico","institution_ids":["https://openalex.org/I129858807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120125698","display_name":"Cesar Alonso Marin-Aranda","orcid":null},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Cesar Alonso Marin-Aranda","raw_affiliation_strings":["Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico"],"affiliations":[{"raw_affiliation_string":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico","institution_ids":["https://openalex.org/I129858807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120125699","display_name":"Aldo Hiram Tovar-Dom\u00ednguez","orcid":null},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Aldo Hiram Tovar-Dom\u00ednguez","raw_affiliation_strings":["Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico"],"affiliations":[{"raw_affiliation_string":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico","institution_ids":["https://openalex.org/I129858807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004015566","display_name":"Jos\u00e9 Marcos Falc\u00f3n-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-0634-2784"},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Marcos Falc\u00f3n-Gonz\u00e1lez","raw_affiliation_strings":["Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico. jfalcong@ipn.mx","Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico"],"affiliations":[{"raw_affiliation_string":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico. jfalcong@ipn.mx","institution_ids":[]},{"raw_affiliation_string":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato, Instituto Polit\u00e9cnico Nacional, Av. Mineral de Valenciana No. 200, Col. Fraccionamiento Industrial Puerto Interior, 36275, Silao de la Victoria, Guanajuato, Mexico","institution_ids":["https://openalex.org/I129858807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062659798"],"corresponding_institution_ids":["https://openalex.org/I129858807"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33180778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"2","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6801000237464905},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6650999784469604},{"id":"https://openalex.org/keywords/molecular-model","display_name":"Molecular model","score":0.6419000029563904},{"id":"https://openalex.org/keywords/conformational-isomerism","display_name":"Conformational isomerism","score":0.590399980545044},{"id":"https://openalex.org/keywords/solvation","display_name":"Solvation","score":0.5555999875068665},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5063999891281128},{"id":"https://openalex.org/keywords/intramolecular-force","display_name":"Intramolecular force","score":0.49709999561309814},{"id":"https://openalex.org/keywords/molecular-mechanics","display_name":"Molecular mechanics","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6801000237464905},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6650999784469604},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.6419000029563904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6337000131607056},{"id":"https://openalex.org/C18705241","wikidata":"https://www.wikidata.org/wiki/Q1128023","display_name":"Conformational isomerism","level":3,"score":0.590399980545044},{"id":"https://openalex.org/C148093993","wikidata":"https://www.wikidata.org/wiki/Q739398","display_name":"Solvation","level":3,"score":0.5555999875068665},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5063999891281128},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.49709999561309814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46709999442100525},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.450300008058548},{"id":"https://openalex.org/C25057246","wikidata":"https://www.wikidata.org/wiki/Q1344441","display_name":"Molecular mechanics","level":3,"score":0.41100001335144043},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3813000023365021},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.3605000078678131},{"id":"https://openalex.org/C64147673","wikidata":"https://www.wikidata.org/wiki/Q6007318","display_name":"Implicit solvation","level":4,"score":0.32280001044273376},{"id":"https://openalex.org/C2989255885","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Molecular conformation","level":3,"score":0.31769999861717224},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.301800012588501},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C14961307","wikidata":"https://www.wikidata.org/wiki/Q5377176","display_name":"Energy minimization","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C84551667","wikidata":"https://www.wikidata.org/wiki/Q155640","display_name":"Potential energy","level":2,"score":0.25839999318122864}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-025-00675-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00675-4","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:41136641","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41136641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1782095941","https://openalex.org/W1918796765","https://openalex.org/W1966481308","https://openalex.org/W1968984443","https://openalex.org/W1970515047","https://openalex.org/W1970799005","https://openalex.org/W1976161355","https://openalex.org/W1976499671","https://openalex.org/W1980461963","https://openalex.org/W2007440728","https://openalex.org/W2008517160","https://openalex.org/W2035266068","https://openalex.org/W2057477511","https://openalex.org/W2060872117","https://openalex.org/W2064160269","https://openalex.org/W2066624199","https://openalex.org/W2067174909","https://openalex.org/W2069123478","https://openalex.org/W2070753604","https://openalex.org/W2081693079","https://openalex.org/W2105668062","https://openalex.org/W2106140689","https://openalex.org/W2115107257","https://openalex.org/W2118233996","https://openalex.org/W2134967712","https://openalex.org/W2143783928","https://openalex.org/W2146124388","https://openalex.org/W2148512505","https://openalex.org/W2149302140","https://openalex.org/W2158534713","https://openalex.org/W2171268876","https://openalex.org/W2304450774","https://openalex.org/W2400827880","https://openalex.org/W2550887636","https://openalex.org/W2755874335","https://openalex.org/W2783351753","https://openalex.org/W2784213390","https://openalex.org/W2808792445","https://openalex.org/W2808844862","https://openalex.org/W2906773141","https://openalex.org/W2981410328","https://openalex.org/W3016296419","https://openalex.org/W3022056244","https://openalex.org/W3039966873","https://openalex.org/W3115142961","https://openalex.org/W3191624963","https://openalex.org/W3202287440","https://openalex.org/W3210455285","https://openalex.org/W4238102997","https://openalex.org/W4246043393","https://openalex.org/W4309391087","https://openalex.org/W4387164156","https://openalex.org/W4403909019","https://openalex.org/W4410629127"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-24T00:00:00"}